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Polymer Bulletin
Published in: Polymer Bulletin 2/2009

01-02-2009 | Original Paper

pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior

Authors: K. S. V. Krishna Rao, Chang-Sik Ha

Published in: Polymer Bulletin | Issue 2/2009

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Abstract

pH Sensitive poly(acryl amide-co-2-acrylamido-2-methyl-1-propanesulfonic acid-co-acrylamidoglycolic acid) hydrogels were synthesized by free-radical copolymerization. These hydrogels were prepared with different ratios of monomers and a crossliker. These hydrogels were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The diffusional exponent (n) values of synthesized hydrogels were found to be in the range between 0.49 and 0.59, indicating a quasi-Fickian diffusion mechanism with partly chain relaxation controlled diffusion. The hydrogels demonstrated a sharp change in its water absorbency and molecular weight between crosslinks of the network with a change in pH of the swelling media. 5-fluorouracil has been used as a model drug to study the drug release capability of these hydrogels.
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Literature
1.
Peppas NA, Huang Y, Lugo MT, Ward JH, Zhang J (2000) Physicochemical foundations and structural design of hydrogels in medicine and biology. Annu Rev Biomed Eng 2:9CrossRef
2.
Savas H, Guven O (2001) Investigation of active substance release from poly (ethylene oxide) hydrogels. Int J Pharm 224:151–158CrossRef
3.
Thomas JB, Creecy CM, McGinity JW, Peppas NA (2006) Synthesis and properties of lightly crosslinked poly (meth) acrylic acid microparticles prepared by free radical precipitation polymerization. Polym Bull 57:11CrossRef
4.
Chen G, Hoffman AS (1995) Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 373:49CrossRef
5.
Hu Z, Lu X, Gao J (2001) Hydrogel Opals. Adv Mater 13:1708–1712
6.
Zhang JT, Cheng SX, Huang SW, Zhuo RX (2003) Temperature-sensitive poly(N-isopropylacrylamide) hydrogels with macroporous structure and fast response rate. Macromol Rapid Commun 24:447CrossRef
7.
Zhang JT, Huang SW, Gao FZ, Zhuo RX (2005) Novel temperature-sensitive, b-cyclodextrin-incorporated poly(N-isopropylacrylamide) hydrogels for slow release of drug. Colloid Polym Sci 283:461CrossRef
8.
Vassilev K, Turmanova S (2008) Complexes of poly(2-N,N-dimethylaminoethyl) methacrylate with heavy metals I. Preparation and properties. Polym Bull 60:243CrossRef
9.
Jabbari E, Nozari S (2000) Swelling behavior of acrylic acid hydrogels prepared by γ-radiation crosslinking of polyacrylic acid in aqueous solution. Eur Polym J 36:2685CrossRef
10.
Kaetsu I, Uchida K, Sshindo H, Gomi S, Sutani K (1999) Intelligent type controlled release systems by radiation techniques. Radiat Phys Chem 55:193–201CrossRef
11.
Gupta P, Vermani K, Garg S (2002) Hydrogels: from controlled release to pH-responsive drug delivery. Drug Deliv Day 7:569
12.
Ottenbrite RM, Kuus K, Kaplan AM (1983) Microencapsulation of mammalian cells in a biocompatible polyacrylate: a progress report. In: Chiellini E, Giusti P (eds) Polymers in medicine. Plenum, New York, p 3
13.
Lee JH, Oh JY, Kim DM (1999) MMA/MPEOMA copolymers as coating materials for improved blood compatibility: protein adsorption study. J Mater Sci Mater Med 10:629CrossRef
14.
Han DK, Jeong SY, Lee YH, Min BG, Cho HI (1991) Negative cilia concept for thromboresistance: synergistic effect of PEO and sulfonate groups grafted onto polyurethanes. J Biomed Mater Res 25:561–575CrossRef
15.
Lee SM, Ju SS, Chung HY, Ha CS, Cho WJ (2001) Syntheses and antitumor activities of polymers containing 2-acrylamido-2-methyl-1-propanesulfonic acid or 5-fluorouracil. Polym Bull 46:241–248CrossRef
16.
Son YK, Kim JH, Jeon YS, Chung DJ (2007) Macromol Res 15:527
17.
Baba M, Schols D, Pauwels R, Nakashima H, De-Clercq EJ (1990) Sulfated polysaccharides as potent inhibitors of HIV-induced syncytium formation: a new strategy towards AIDS chemotherapy. Acquir Immunodefic Syndr 3:493
18.
Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY (2008) Swelling behavior and drug release of poly (vinyl alcohol) hydrogel cross-linked with poly (acrylic acid). Macromol Res 16:189
19.
Lei J, Kim JH, Jeon YS (2008) Macromol Res 16:45
20.
Mbemba E, Chams V, Gluckman JC, Klatzmann D, Gattegno L (1992) Molecular interaction between HIV-1 major envelope glycoprotein and dextran sulfate. Biochim Biophys Acta 1138:62–67
21.
Neyts J, Reymen D, Letourneur D, Jozefonvicz J, Schols D, Este J, Andrei G, McKenna P, Witvrouw M, Ikeda S, Clement J, De Clercq E (1995) Differential antiviral activity of derivatized dextrans. Biochem Pharmacol 50:743–751CrossRef
22.
Rao PS, Sridhar S, Krishnaiah A, Wey MY (2007) Ind Eng Chem Res 45:2155–2163
23.
Harogoppad SB, Aminabhavi TM (1991) Diffusion and sorption of organic liquids through polymer membranes. II. Neoprene, SBR, EPDM, NBR, and natural rubber versus n-alkanes. J Appl Polym Sci 42:2329–2336CrossRef
24.
Garcia O, Trigo RM, Blanco MD, Teijon JM (1994) Influence of degree of crosslinking on 5-fluorouracil release from poly(2-hydroxyethyl methacrylate) hydrogels. Biomaterials 15:689CrossRef
25.
Yoshida R, Okuyama Y, Sakai K, Okano T, Sakurai Y (1994) Sigmoidal swelling profiles for temperature-responsive poly(N-isopropylacrylamide-co-butyl methacrylate) hydrogels. J Membr Sci 89:267–277CrossRef
26.
Khokhlov AR, Kramarenko E Yu (1994) Polyelectrolyte/Ionomer behavior in polymer gel collapse. Makromol Theory Simul 3:45
27.
Korsmeyer RW, Peppas NA (1983) Controlled release delivery systems. Marcel Dekker, New York
28.
Lee WF, Shieh CH (1999) pH-thermoreversible hydrogels. II. Synthesis and swelling behaviors of N-isopropylacrylamide-co-acrylic acid-co-sodium acrylate hydrogels. J Appl Polym Sci 73:1955CrossRef
29.
Tamura T, Kawabata N, Satoh M (2000) Swelling behavior of poly(α-hydroxy acrylic acid) gel in water/organic solvent mixtures. Polym Bull 44:209CrossRef
30.
Flory PJ (1953) Principles of polymer chemistry. Cornell University Press, Ithaca
31.
Mark JE, Erman B (1988) Rubberlike elasticity: a molecular primer. Wiley, New York
32.
Xue W, Champ S, Huglin MB (2001) Network and swelling parameters of chemically crosslinked thermoreversible hydrogels. Polymer 42:3665CrossRef
Metadata
Title
pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior
Authors
K. S. V. Krishna Rao
Chang-Sik Ha
Publication date
01-02-2009
Publisher
Springer-Verlag
Published in
Polymer Bulletin / Issue 2/2009
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-008-0011-1

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