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Polymer Bulletin
Erschienen in: Polymer Bulletin 2/2009

01.02.2009 | Original Paper

pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior

Erschienen in: Polymer Bulletin | Ausgabe 2/2009

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Abstract

pH Sensitive poly(acryl amide-co-2-acrylamido-2-methyl-1-propanesulfonic acid-co-acrylamidoglycolic acid) hydrogels were synthesized by free-radical copolymerization. These hydrogels were prepared with different ratios of monomers and a crossliker. These hydrogels were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The diffusional exponent (n) values of synthesized hydrogels were found to be in the range between 0.49 and 0.59, indicating a quasi-Fickian diffusion mechanism with partly chain relaxation controlled diffusion. The hydrogels demonstrated a sharp change in its water absorbency and molecular weight between crosslinks of the network with a change in pH of the swelling media. 5-fluorouracil has been used as a model drug to study the drug release capability of these hydrogels.
Vorheriger Artikel Synthesis of pure (Co) polymers via supported cobalt (II)-catalyzed controlled/“living” radical polymerization
Nächster Artikel Preparation and in vitro controlled release behavior of a novel pH-sensitive drug carrier for colon delivery

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Metadaten
Titel
pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior
Publikationsdatum
01.02.2009
Erschienen in
Polymer Bulletin / Ausgabe 2/2009
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-008-0011-1

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