Top

Cellulose

Published in:

11-11-2018 | Original Paper

Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions

Authors: Zhiguo Wang, Rong Wang, Pengbo Xu, Juan Yu, Liang Liu, Yimin Fan

Published in: Cellulose | Issue 2/2019

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

A physical composite nanochitin/microemulsion (NCh/ME) hydrogel for a prolonged release of hydrophobic compounds (drugs) under in vitro physiological conditions was investigated. A strong physical hydrogel was prepared by an alkali gas phase coagulation bath composting NCh with an oil in water ME in which a hydrophobic dye, Nile Red (NR), was embedded to simulate a drug release process. Different release conditions, such as concentration of NCh, diameter of ME, temperature and specific surface areas, were studied. The results showed that the NCh/ME composite hydrogel effectively encapsulated NR with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of NCh/ME composite hydrogels for hydrophobic compound (drug) delivery.

Graphical abstract

previous article Selective extraction of gadolinium using free-standing imprinted mesoporous carboxymethyl chitosan films with high capacity

next article A study on adsorption isotherm and kinetics of petroleum by cellulose cryogels

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Arora S, Ali J, Ahuja A et al (2005) Floating drug delivery systems: a review. AAPS PharmSciTech 6(3):E372–E390CrossRef

Bhattarai N, Gunn J, Zhang M (2010) Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 62(1):83–99CrossRef

Chang C, Chen S, Zhang L (2011) Novel hydrogels prepared via direct dissolution of chitin at low temperature: structure and biocompatibility. J Mater Chem 21(11):3865–3871CrossRef

Chen C, Yano H, Li D et al (2015) Preparation of high-strength α-chitin nanofiber-based hydrogels under mild conditions. Cellulose 22(4):2543–2550CrossRef

Delmar K, Bianco-Peled H (2016) Composite chitosan hydrogels for extended release of hydrophobic drugs. Carbohydr Polym 136:570–580CrossRef

Fan Y, Saito T, Isogai A (2010) Individual chitin nano-whiskers prepared from partially deacetylated α-chitin by fibril surface cationization. Carbohydr Polym 79(4):1046–1051CrossRef

Focher B, Naggi A, Torri G et al (1992) Structural differences between chitin polymorphs and their precipitates from solutions-evidence from CP-MAS 13C-NMR, FT-IR and FT-Raman spectroscopy. Carbohydr Polym 17(2):97–102CrossRef

Guillot F, Domard A (2005) Composition for cutaneous repair and cicatrization comprising exclusively a true physical hydrogel of chitosan. U.S. patent application 10/915, 621.2-24

Hu X, Tang Y, Wang Q et al (2011) Rheological behaviour of chitin in NaOH/urea aqueous solution. Carbohydr Polym 83(3):1128–1133CrossRef

Jayakumar R, Menon D, Manzoor K et al (2010) Biomedical applications of chitin and chitosan based nanomaterials—a short review. Carbohydr Polym 82(2):227–232CrossRef

Josef E, Barat K, Barsht I et al (2013) Composite hydrogels as a vehicle for releasing drugs with a wide range of hydrophobicities. Acta Biomater 9(11):8815–8822CrossRef

Khurma JR, Nand AV (2008) Temperature and pH sensitive hydrogels composed of chitosan and poly(ethylene glycol). Polym Bull 59(6):805–812CrossRef

Klossner RR, Queen HA, Coughlin AJ et al (2008) Correlation of chitosan’s rheological properties and its ability to electrospin. Biomacromolecules 9(10):2947–2953CrossRef

Kogan A, Garti N (2006) Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci 123:369–385CrossRef

Lawrence MJ, Rees GD (2000) Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 45(1):89–121CrossRef

Li L, Lin Z, Yang X et al (2009) A novel cellulose hydrogel prepared from its ionic liquid solution. Chin Sci Bull 54(9):1622–1625

Liu J, Zhang L, Yang Z et al (2011) Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro. Int J Nanomed 6:2143CrossRef

Liu L, Lv H, Jiang J et al (2015a) Reinforced chitosan beads by chitin nanofibers for the immobilization of β-glucosidase. RSC Adv 5(113):93331–93336CrossRef

Liu Y, Gu J, Zhang J et al (2015b) LiFePO₄ nanoparticles growth with preferential (010) face modulated by Tween-80. RSC Adv 5(13):9745–9751CrossRef

Liu L, Wang R, Yu J et al (2016) Robust self-standing chitin nanofiber/nanowhisker hydrogels with designed surface charges and ultralow mass content via gas phase coagulation. Biomacromolecules 17(11):3773–3781CrossRef

Mir VG, Heinämäki J, Antikainen O et al (2008) Direct compression properties of chitin and chitosan. Eur J Pharm Biopharm 69(3):964–968CrossRef

Pillai CKS, Paul W, Sharma CP (2009) Chitin and chitosan polymers: chemistry, solubility and fiber formation. Prog Polym Sci 34(7):641–678CrossRef

Rwei SP, Lyu MS, Wu P et al (2009) Sol/gel transition and liquid crystal transition of HPC in ionic liquid. Cellulose 16(1):9–17CrossRef

Sriupayo J, Supaphol P, Blackwell J et al (2005) Preparation and characterization of α-chitin whisker-reinforced chitosan nanocomposite films with or without heat treatment. Carbohydr Polym 62(2):130–136CrossRef

Tenjarla S (1999) Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst 16(5):461–521CrossRef

Wang R, Liu L, Yu J et al (2017) Versatile protonic acid mediated preparation of partially deacetylated chitin nanofibers/nanowhiskers and their assembling of nano-structured hydro- and aero-gels. Cellulose 12:1–12

Title: Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions
Authors: Zhiguo Wang
Rong Wang
Pengbo Xu
Juan Yu
Liang Liu
Yimin Fan
Publication date: 11-11-2018
Publisher: Springer Netherlands
Published in: Cellulose / Issue 2/2019
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-018-2119-2

Springer Professional

Abstract

Graphical abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Springer Professional "Wirtschaft+Technik"

Other articles of this Issue 2/2019

Rheology of microfibrillated cellulose (MFC) suspensions: influence of the degree of fibrillation and residual fibre content on flow and viscoelastic properties

High strength biocomposites consolidated from hardwood particles by severe plastic deformation

The effects of huntite–hydromagnesite inclusion in acrylate-based polymer paste coating process on some textile functional performance properties of cotton fabric

A high-performance all-solid-state yarn supercapacitor based on polypyrrole-coated stainless steel/cotton blended yarns

Analysis of cellulose nanocrystals (CNCs) with flow cytometry

Microwave assisted in situ synthesis of gum Salai guggal based silver nanocomposites- investigation of anti-bacterial properties