Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Colloid and Polymer Science
Published in: Colloid and Polymer Science 14-15/2008

01-12-2008 | Original Contribution

Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide

Authors: Mauro Vaccaro, Gaetano Mangiapia, Antonella Accardo, Diego Tesauro, Eliana Gianolio, Henrich Frielinghaus, Giancarlo Morelli, Luigi Paduano

Published in: Colloid and Polymer Science | Issue 14-15/2008

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Two novel amphiphilic unimers containing an aliphatic hydrophobic chain (PDA) with two C≡C triple bonds and hydrophilic heads presenting the chelating agent DTPAGlu and the CCK8 bioactive peptide, respectively, have been prepared by solid phase synthesis. Aggregates obtained by mixing together PDA-DTPAGlu, or its Gd(III) complex, and PDA-L2-CCK8 in 70/30 molar ratio before and after a polymerization process carried out by UV irradiation have been structurally characterized by means of small angle neutron scattering. The relaxivity properties of aggregates containing Gadolinium complexes have also been investigated. Elongated mixed micelles have been observed, in which the relaxivity value r 1p for each Gadolinium complex, measured at 20 MHz and 298 K, is around 12 mM–1 s–1.
previous article Evaluation of structural change during surface pressure relaxation in Langmuir monolayer of zinc stearate by infrared external reflection spectroscopy
next article Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
Literature
1.
Weissleder R, Mahmood U (2001) Molecular imaging. Radiology 219:316–333 Oak Brook, IL, United States
2.
Aime S, Cabella C, Colombatto S, Geninatti Crich S, Gianolio E, Maggioni F (2002) Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J Magn Reson Imaging Field 16:394–406CrossRef
3.
Aime S, Fasano M, Terreno E, Botta M (2001) Protein-bound metal chelates. In: Merbach A, Toth E (eds) Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. Wiley, New York, pp 193–241
4.
Gao J, Nasongkla N, Khemtong C (2007) cRGD-encoded, MRI-visible polymeric micelles for tumor-targeted drug delivery. In: Amiji M (ed) Nanotechnology for Cancer Therapy. CRC, Boca Raton, pp 465–475 1 plate
5.
Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G (2004) Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor-specific contrast agents in MRI. J Am Chem Soc 126:3097–3107CrossRef
6.
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillen K (2007) High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI. JBIC, J Biol Inorg Chem 12:267–276CrossRef
7.
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillen K, Aime S, Morelli G (2007) Peptide derivatized lamellar aggregates as target-specific MRI contrast agents. ChemBioChem 8:950–955CrossRef
8.
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G (2007) Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI. ChemPhysChem 8:2526–2538CrossRef
9.
Evans DF (1998) The colloidal domain: where physics, chemistry, biology, and technology meet, 2nd edn. Wiley, New York
10.
Zou G, Fang K, Xia S, He P (2002) Elasticity of 10,12-pentacosadiynoic acid monolayer and the polymerized monolayer at varying pH and temperatures. Langmuir 18:6602–6605CrossRef
11.
Reubi JC, Schaer J-C, Waser B (1997) Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res 57:1377–1386
12.
Anelli PL, Fedeli F, Gazzotti O, Lattuada L, Lux G, Rebasti F (1999) L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands. Bioconjug Chem 10:137–140CrossRef
13.
Chan WC, White PD (2000) Basic procedures. Fmoc Solid Phase Peptide Synthesis. Oxford University Press, Oxford, pp 41–76
14.
Edelhoch H (1967) Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry 6:1948–1954CrossRef
15.
Pace CN, Vajdos F, Fee L, Grimsley G, Gray T (1995) How to measure and predict the molar absorption coefficient of a protein. Protein Sci Field 4:2411–2423
16.
Birdi KS, Singh HN, Dalsager SU (1979) Interaction of ionic micelles with the hydrophobic fluorescent probe 1-anilino-8-naphthalenesulfonate. J Phys Chem 83:2733–7CrossRef
17.
De Vendittis E, Palumbo G, Parlato G, Bocchini V (1981) A fluorimetric method for the estimation of the critical micelle concentration of surfactants. Anal Biochem 115:278–286CrossRef
18.
Lakowicz JR (1983) Principles of Fluorescence Spectroscopy. Springer, New York
19.
Wignall GD, Bates FS (1987) Absolute calibration of small-angle neutron scattering data. J Appl Crystallogr 20:28–40CrossRef
20.
Russell TP, Lin JS, Spooner S, Wignall GD (1988) Intercalibration of small-angle x-ray and neutron scattering data. J Appl Crystallogr 21:629–638CrossRef
21.
Shinoda K, Nakagawa T, Tamamushi B, Isemura T (1962) Colloidal Surfactants, Some Physicochemical Properties. Academy, New York
22.
Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Gadolinium(III) Chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev (Washington, D. C.) 99:2293–2352
23.
Lipari G, Szabo A (1982) Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity. J Am Chem Soc 104:4546–4559CrossRef
24.
Lipari G, Szabo A (1982) Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 2. Analysis of experimental results. J Am Chem Soc 104:4559–4570CrossRef
25.
Torres S, Martins JA, Andre JP, Geraldes CFGC, Merbach AE, Toth E (2006) Supramolecular assembly of an amphiphilic GdIII chelate: Tuning the reorientational correlation time and the water exchange rate. Chem–Eur J 12:940–948
26.
Nicolle GM, Toth E, Eisenwiener K-P, Macke HR, Merbach AE (2002) From monomers to micelles: investigation of the parameters influencing proton relaxivity. JBIC, J Biol Inorg Chem 7:757–769CrossRef
27.
Nicolle GM, Tóth É, Schmitt-Willich H, Radchel B, Merbach AE (2002) The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent. Chem - Eur J 8:1040–1048CrossRef
28.
Kotlarchyk M, Chen SH (1983) Analysis of small angle neutron scattering spectra from polydisperse interacting colloids. J Chem Phys 79:2461–2469CrossRef
Metadata
Title
Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
Authors
Mauro Vaccaro
Gaetano Mangiapia
Antonella Accardo
Diego Tesauro
Eliana Gianolio
Henrich Frielinghaus
Giancarlo Morelli
Luigi Paduano
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Colloid and Polymer Science / Issue 14-15/2008
Print ISSN: 0303-402X
Electronic ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-008-1940-9

Other articles of this Issue 14-15/2008

Colloid and Polymer Science 14-15/2008 Go to the issue

Original Contribution

Rheological behavior of viscoelastic wormlike micelles in mixed sodium dodecyl trioxyethylene sulfate–monolaurin aqueous system

Short Communication

Photo-living radical polymerization of methyl methacrylate by a nitroxide mediator

Original Contribution

Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles

Original Contribution

Translation of two coaxial, nonhomogeneously structured flocs normal to a plate

Original Contribution

Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

Original Contribution

Evaluation of structural change during surface pressure relaxation in Langmuir monolayer of zinc stearate by infrared external reflection spectroscopy

Premium Partners

    Image Credits