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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 14-15/2008

01.12.2008 | Original Contribution

Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide

verfasst von: Mauro Vaccaro, Gaetano Mangiapia, Antonella Accardo, Diego Tesauro, Eliana Gianolio, Henrich Frielinghaus, Giancarlo Morelli, Luigi Paduano

Erschienen in: Colloid and Polymer Science | Ausgabe 14-15/2008

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Abstract

Two novel amphiphilic unimers containing an aliphatic hydrophobic chain (PDA) with two C≡C triple bonds and hydrophilic heads presenting the chelating agent DTPAGlu and the CCK8 bioactive peptide, respectively, have been prepared by solid phase synthesis. Aggregates obtained by mixing together PDA-DTPAGlu, or its Gd(III) complex, and PDA-L2-CCK8 in 70/30 molar ratio before and after a polymerization process carried out by UV irradiation have been structurally characterized by means of small angle neutron scattering. The relaxivity properties of aggregates containing Gadolinium complexes have also been investigated. Elongated mixed micelles have been observed, in which the relaxivity value r 1p for each Gadolinium complex, measured at 20 MHz and 298 K, is around 12 mM–1 s–1.
Vorheriger Artikel Evaluation of structural change during surface pressure relaxation in Langmuir monolayer of zinc stearate by infrared external reflection spectroscopy
Nächster Artikel Effect of end group polarity upon the lower critical solution temperature of poly(2-isopropyl-2-oxazoline)

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Metadaten
Titel
Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
verfasst von
Mauro Vaccaro
Gaetano Mangiapia
Antonella Accardo
Diego Tesauro
Eliana Gianolio
Henrich Frielinghaus
Giancarlo Morelli
Luigi Paduano
Publikationsdatum
01.12.2008
Verlag
Springer-Verlag
Erschienen in
Colloid and Polymer Science / Ausgabe 14-15/2008
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-008-1940-9

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