Polyphase filtering with variable mapping rule in protein coding region prediction

Genomic researches are concerned with the study of genomes of organisms. It has become a challenge to the researchers to identify the segments within the DNA sequence that involved in protein synthesis and called coding region of gene. The methods are generally used to identify the segment that relies on period-3 property of genes. This period-3 property easily can be identified by digital signal processing with great accuracy. Prior to DSP application in gene prediction a conversion rule is required which converts symbolic DNA (ATCGTC…) sequence into numerical representations. Accuracy of gene prediction depends on mapping rule. The effectiveness of mapping rule depends on the application area of genomics. Some mapping rule works well in gene prediction may not performed good in genetic disease prediction. Most of the available conversion rules are fixed mapping technique. In this paper a new conversion rule is proposed prior to DSP application and a polyphase filter is used to suppress the noise in the DNA spectrum. The performance of the proposed mapping is compared with existing mapping and also the performance of the polyphase filtering method is compared with existing filtering methods in terms of signal to noise ratio (SNR) and location accuracy.