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Journal of Sol-Gel Science and Technology

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17-05-2022 | Original Paper: Nano-structured materials (particles, fibers, colloids, composites, etc.)

Preparation and properties of pH-responsive magnetic mesoporous silica drug carrier

Authors: Shisheng Lai, Haoqing Wang, Ning Qiao, Hongzhou Shang, Xiaoran Sun, Zimeng Wang, Qi Li, Yujin Lu, Xuepeng Zhang

Published in: Journal of Sol-Gel Science and Technology | Issue 1/2022

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Abstract

A novel pH-responsive magnetic drug carrier system of Fe₃O₄/mSiO₂/CMCS-PDMAEMA was prepared. Around the core of magnetic Fe₃O₄, the mesoporous silica was shelled. In contrast, the copolymer of carboxymethyl chitosan (CMCS) and Poly [2-(Dimethylamino)ethyl methacrylate] (PDMAEMA) exerted a pH-responsive effect. The core of magnetic Fe₃O₄ played the role of magnetic targeting. Fe₃O₄/mSiO₂/CMCS-PDMAEMA particles were produced and characterized in terms of their structure, magnetic properties, drug adsorption, and release behavior. The diameter of the designed Fe₃O₄/mSiO₂/CMCS-PDMAEMA particles was about 1.3 µm, and the saturation magnetization value was 18.41 emu/g. The drug adsorption and release capacity of the developed carrier was evaluated using DOX as a model drug. The developed carrier had superior pH sensitivity, with a high release rate at pH 3. During this time, drug loading rates and encapsulation rates were 6.62% and 44.14%, respectively.

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Title: Preparation and properties of pH-responsive magnetic mesoporous silica drug carrier
Authors: Shisheng Lai
Haoqing Wang
Ning Qiao
Hongzhou Shang
Xiaoran Sun
Zimeng Wang
Qi Li
Yujin Lu
Xuepeng Zhang
Publication date: 17-05-2022
Publisher: Springer US
Published in: Journal of Sol-Gel Science and Technology / Issue 1/2022
Print ISSN: 0928-0707
Electronic ISSN: 1573-4846
DOI: https://doi.org/10.1007/s10971-022-05829-6

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