Top

Polymer Bulletin

Published in:

23-01-2022 | Original Paper

Preparation of FK-SA conjugate gel beads with double cross-linking for pH-controllable drug releasing

Authors: Zejun Wang, Jiarui Ren, Lizhong Qian, Yufeng He, Pengfei Song, Rongmin Wang

Published in: Polymer Bulletin | Issue 1/2023

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Using feather keratin (FK), a kind of biocompatible natural polymer being extracted from widely available and renewable waste feathers, and sodium alginate (SA) as materials, the FK conjugated SA gel beads (FK-SA-Gbs) were prepared with double cross-linked by calcium ion (Ca²⁺) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). After being characterized and analyzed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD), its pH responsiveness, salt ion responsiveness, and degradability were measured, and the loading capacity of model drug Rhodamine B (RhB) under various physical conditions, the cumulative release rate of the loaded gel beads in different pH buffer solutions were also investigated. The results showed that the FK-SA-Gbs had significant pH sensitivity and sustained release, and various physical conditions can meet the requirements of wound dressings. It indicated FK-SA-Gbs can be used as controlled release drug carriers and are expected to be used as drug carrier materials in biomedical applications.

Graphical abstract

FK conjugated SA gel beads (FK-SA-Gbs) was prepared by secondary cross-linking with CaCl₂ and 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC/HCl) using feather keratin (FK) extracted from waste feathers, which have significant pH sensitivity and sustained release capability.

previous article Preparation of UV-LED curable antifouling and flame retardant superhydrophobic coatings for polyethylene terephthalate surface protection

next article Synthesis and properties of poly(silylene bis(ethynylphenoxy)diphenylsulfone)

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS, Jemal A (2014) Cancer treatment and survivorship statistics. CA Cancer J Clin 64(4):252–271. https://doi.org/10.3322/caac.21235CrossRef

Hubbell JA, Langer R (2013) Translating materials design to the clinic. Nat Mater 12(11):963–966. https://doi.org/10.1038/nmat3788CrossRef

Elsabahy M, Wooley KL (2012) Design of polymeric nanoparticles for biomedical delivery applications. Chem Soc Rev 41(7):2545–2561. https://doi.org/10.1039/C2CS15327KCrossRef

Sun K, Guo J, He Y, Song P, Xiong Y, Wang RM (2016) Fabrication of dual-sensitive keratin-based polymer hydrogels and their controllable release behaviors. J Biomat Sci Polym Ed 27(18):1926–1940. https://doi.org/10.1080/09205063.2016.1239955CrossRef

Jiang T, Mo R, Bellotti A, Zhou J, Gu Z (2014) Gel-liposome-mediated co-delivery of anticancer membrane-associated proteins and small-molecule drugs for enhanced therapeutic efficacy. Adv Funct Mater 24(16):2295–2304. https://doi.org/10.1002/adfm.201303222CrossRef

Li X, Gao F, Dong Y, Li X (2019) Strategies to regulate the degradability of mesoporoussilica-based nanoparticles for biomedical applications. Nano 14(12):1930008. https://doi.org/10.1142/S1793292019300081CrossRef

Xu R, Zhang G, Mai J, Deng X, Segura-Ibarra V, Wu S, Shen J, Liu H, Hu Z, Chen L, Huang Y, Koay E, Huang Y, Liu J, Ensor JE, Blanco E, Liu X, Ferrari M, Shen H (2016) An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nat Biotechnol 34(4):414–418. https://doi.org/10.1038/nbt.3506CrossRef

Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12(11):991–1003. https://doi.org/10.1038/NMAT3776CrossRef

Petros RA, DeSimone JM (2010) Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 9(8):615–627. https://doi.org/10.1038/nrd2591CrossRef

10.

Fang R, Yang S, Wang Y, Qian H (2015) Nanoscale drug delivery systems: A current review on the promising paclitaxel formulations for future cancer therapy. Nano 10(5):1530004. https://doi.org/10.1142/S1793292015300042CrossRef

11.

Cai K, He X, Song Z, Yin Q, Zhang Y, Uckun FM, Jiang C, Cheng J (2015) Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency. J Am Chem Soc 137(10):3458–3461. https://doi.org/10.1021/ja513034eCrossRef

12.

Hubbell JA, Chilkoti A (2012) Nanomaterials for drug delivery. Science 337(6092):303–305. https://doi.org/10.1126/science.1219657CrossRef

13.

Chung JE, Tan S, Gao SJ, Yongvongsoontorn N, Kim SH, Lee JH, Choi HS, Yano H, Zhuo L, Kurisawa M, Ying JY (2014) Self-assembled micellar nanocomplexes comprising greentea catechin derivatives and protein drugs for cancer therapy. Nat Nano 9(11):907–912. https://doi.org/10.1038/nnano.2014.208CrossRef

14.

Li XM, Wang B, He YF, Song P, Yan G, Wang R (2021) Soybean protein isolate-based microgels bounding amino acid metal complexes for scavenging superoxide anion radicals. Polym Bull 78(2):713–728. https://doi.org/10.1007/s00289-020-03121-7CrossRef

15.

Stergar J, Maver U (2016) Review of aerogel-based materials in biomedical applications. J Sol–Gel Sci Techn 77(3):738–752. https://doi.org/10.1007/s10971-016-3968-5CrossRef

16.

Franke-Whittle IH, Insam H (2013) Treatment alternatives of slaughterhouse wastes, and their effect on the inactivation of different pathogens: a review. Crit Rev Microbiol 39(2):139–151. https://doi.org/10.3109/1040841X.2012.694410CrossRef

17.

Li M, Zhu Z, Pan X (2011) Effects of starch acryloylation on the grafting efficiency, adhesion, and film properties of acryloylated starch-g-poly (acrylic acid) for warp sizing. Starch-Starke 63(11):683–691. https://doi.org/10.1002/star.201100002CrossRef

18.

Kucinska JK, Magnucka EG, Oksinska MP, Pietr SJ (2014) Bio efficacy of hen feather keratin hydrolysate and compost on vegetable plant growth. Compost Sci Util 22(3):179–187. https://doi.org/10.1080/1065657X.2014.918866CrossRef

19.

Sadeghi S, Dadashian F, Eslahi N (2019) Recycling chicken feathers to produce adsorbent porous keratin-based sponge. Int J Environ Sci Technol 16(2):1119–1128. https://doi.org/10.1007/s13762-018-1669-zCrossRef

20.

Nakata R, Osumi Y, Miyagawa S, Tachibana A, Tanabe T (2015) Preparation of keratin andchemically modified keratin hydrogels and their evaluation as cell substrate with drug releasing ability. J Biosci Bioeng 120(1):111–116. https://doi.org/10.1016/j.jbiosc.2014.12.005CrossRef

21.

Gao L, Li R, Sui X, Li R, Chen C, Chen Q (2014) Conversion of chicken feather waste toN-doped carbon nanotubes for the catalytic reduction of 4-nitrophenol. Environ Sci Technol 48(17):10191–10197. https://doi.org/10.1021/es5021839CrossRef

22.

Pardo-Ibáñez P, Lopez-Rubio A, Martínez-Sanz M, Cabedo L, Lagaron JM (2014) Keratin–polyhydroxyalkanoate melt-compounded composites with improved barrier properties of interest in food packaging applications. J Appl Polym Sci. https://doi.org/10.1002/app.39947CrossRef

23.

Yin XC, Li FY, He YF, Wang Y, Wang RM (2013) Study on effective extraction of chicken feather keratins and their films for controlling drug release. Biomater Sci 1(5):528–536. https://doi.org/10.1039/C3BM00158JCrossRef

24.

Xia W, Xie M, Feng X, Chen L, Zhao Y (2018) Surface modification of poly (vinylidene fluoride) ultrafiltration membranes with chitosan for anti-fouling and antibacterial performance. Macromol Res 26(13):1225–1232. https://doi.org/10.1007/s13233-019-7019-2CrossRef

25.

Feiz S, Navarchian AH (2019) Poly (vinyl alcohol) hydrogel/chitosan-modified clay nanocomposites for wound dressing application and controlled drug release. Macromol Res 27(3):290–300. https://doi.org/10.1007/s13233-019-7046-zCrossRef

26.

Xue Y, Xia X, Yu B, Luo X, Cai N, Long S, Yu F (2015) A green and facile method forthe preparation of a pH-responsive alginate nanogel for subcellular delivery of doxorubicin. RSC Adv 5(90):73416–73423. https://doi.org/10.1039/C5RA13313KCrossRef

27.

Alonso S (2018) Exploiting the bioengineering versatility of lactobionic acid in targeted nano systems and biomaterials. J Control Release 287:216–234. https://doi.org/10.1016/j.jconrel.2018.08.030CrossRef

28.

Sarika PR, James NR (2016) Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery. Carbohyd Polym 148:354–361. https://doi.org/10.1016/j.carbpol.2016.04.073CrossRef

29.

Tam SK, Dusseault J, Polizu S, Ménard M, Hallé JP, Yahia LH (2005) Physicochemical model of alginate-poly-l-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS. Biomaterials 26(34):6950–6961. https://doi.org/10.1016/j.biomaterials.2005.05.007CrossRef

Title: Preparation of FK-SA conjugate gel beads with double cross-linking for pH-controllable drug releasing
Authors: Zejun Wang
Jiarui Ren
Lizhong Qian
Yufeng He
Pengfei Song
Rongmin Wang
Publication date: 23-01-2022
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 1/2023
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-022-04076-7

Springer Professional

Abstract

Graphical abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 1/2023

Green synthesis, characterisation and antibacterial activity studies of new multifunctional nano polymeric material, which may have multidimensional application in water purification

Core–shell to Janus morphologies from co-assembly of polyaniline and hydrophobic polymers in aqueous media

Worldwide fight against COVID-19 using nanotechnology, polymer science, and 3D printing technology

Fabrication and evaluation of nanoencapsulated quercetin for wound healing application

Synthesis and properties of poly(silylene bis(ethynylphenoxy)diphenylsulfone)

Features of redox properties of phenolic structures of coniferous and deciduous lignins in the solid and liquid phase

Premium Partners