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Cognitive Neurodynamics
Published in: Cognitive Neurodynamics 4/2010

01-12-2010 | Review

Sensory evoked and event related oscillations in Alzheimer’s disease: a short review

Authors: Görsev G. Yener, Erol Başar

Published in: Cognitive Neurodynamics | Issue 4/2010

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Abstract

Diagnosis and treatment of Alzheimer’s disease (AD) depend on clinical evaluation and there is a strong need for an objective tool as a biomarker. Our group has investigated brain oscillatory responses in a small group of AD subjects. We found that the de novo (untreated) AD group differs from both the cholinergically-treated AD group and aged-matched healthy controls in theta and delta responses over left frontal-central areas after cognitive stimulation. On the contrary, the difference observed in AD groups upon a sensory visual stimulation includes response increase over primary or secondary visual sensorial areas compared to controls. These findings imply at least two different neural networks, depending on type of stimulation (i.e. cognitive or sensory). The default mode defined as activity in resting state in AD seems to be affected electrophysiologically. Coherences are also very valuable in observing the group differences, especially when a cognitive stimulus is applied. In healthy controls, higher coherence values are elicited after a cognitive stimulus than after a sensory task. Our findings support the notion of disconnectivity of cortico-cortical connections in AD. The differences in comparison of oscillatory responses upon sensory and cognitive stimulations and their role as a biomarker in AD await further investigation in series with a greater number of subjects.
next article Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

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Metadata
Title
Sensory evoked and event related oscillations in Alzheimer’s disease: a short review
Authors
Görsev G. Yener
Erol Başar
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Cognitive Neurodynamics / Issue 4/2010
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-010-9138-5

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