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Journal of Nanoparticle Research

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01-10-2018 | Research Paper

Small antimicrobial agents encapsulated in poly(epsilon-caprolactone)-poly(ethylene glycol) nanoparticles for treatment of S. aureus-infected wounds

Authors: Jisong Hua, Peng Teng, Yingying Zou, Chao Zhang, Xujie Shen, Jianfeng Cai, Yong Hu

Published in: Journal of Nanoparticle Research | Issue 10/2018

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Abstract

The bacterial infections, especially wound infection, have become a growing problem threatening the human health. Small molecular antimicrobial agents were synthesized to fight against the bacteria but the clinical application in wound inflection treatment was restricted because of their hydrophobicity and poor skin permeation. Here, we synthesized a novel quinoline compound to be used as an antimicrobial agent. Due to its hydrophobic property, this quinoline compound could be successfully encapsulated into poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) nanoparticles (NPs) with a mean size of about 100 nm and showed a sustained drug release manner in vitro. Compared to the free drug of this quinoline compound, these drug-loaded PCL-PEG NPs had better water solubility and lower cytotoxicity in vitro. Results of in vivo wound healing experiments demonstrated that these drug-loaded NPs could not only greatly suppress the bacterial infection around the wound, but also significantly accelerate the curing rate of wound. Thus, these quinoline compound-loaded PCL-PEG NPs could act as a promising drug delivery system for wound healing applications.

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Title: Small antimicrobial agents encapsulated in poly(epsilon-caprolactone)-poly(ethylene glycol) nanoparticles for treatment of S. aureus-infected wounds
Authors: Jisong Hua
Peng Teng
Yingying Zou
Chao Zhang
Xujie Shen
Jianfeng Cai
Yong Hu
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 10/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4369-1

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