Skip to main content
Top

2017 | OriginalPaper | Chapter

Smoluchowski Equation with Variable Coefficients in Perforated Domains: Homogenization and Applications to Mathematical Models in Medicine

Authors : Bruno Franchi, Silvia Lorenzani

Published in: Harmonic Analysis, Partial Differential Equations and Applications

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

In this paper, we study the homogenization of a Smoluchowski system of periodic discrete diffusion-coagulation equations, when the diffusion coefficients depend on all variables, in particular on the microscopic variable. This system modelizes the aggregation and diffusion of the β-amyloid peptide Aβ 42 in the cerebral tissue, a process associated with the development of Alzheimer’s disease. Our homogenization result, based on Allaire-Nguetseng two-scale convergence, is meant to pass from a microscopic model to a macroscopic one.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
1.
go back to reference Y. Achdou, B. Franchi, N. Marcello, M.C. Tesi, A qualitative model for aggregation and diffusion of β-Amyloid in Alzheimer’s disease. J. Math. Biol. 67 (6–7), 1369–1392 (2013)MathSciNetCrossRefMATH Y. Achdou, B. Franchi, N. Marcello, M.C. Tesi, A qualitative model for aggregation and diffusion of β-Amyloid in Alzheimer’s disease. J. Math. Biol. 67 (6–7), 1369–1392 (2013)MathSciNetCrossRefMATH
3.
go back to reference G. Allaire, A. Damlamian, U. Hornung, Two-scale convergence on periodic surfaces and applications, in Proceedings of the International Conference on Mathematical Modelling of Flow Through Porous Media, ed. by A. Bourgeat et al. (World Scientific Publication, Singapore, 1996), pp. 15–25 G. Allaire, A. Damlamian, U. Hornung, Two-scale convergence on periodic surfaces and applications, in Proceedings of the International Conference on Mathematical Modelling of Flow Through Porous Media, ed. by A. Bourgeat et al. (World Scientific Publication, Singapore, 1996), pp. 15–25
4.
5.
go back to reference M. Bertsch, B. Franchi, N. Marcello, M.C. Tesi, A. Tosin, Alzheimer’s disease: a mathematical model for onset and progression. Math. Med. Biol. (2016). doi:10.1093/imammb/dqw003 M. Bertsch, B. Franchi, N. Marcello, M.C. Tesi, A. Tosin, Alzheimer’s disease: a mathematical model for onset and progression. Math. Med. Biol. (2016). doi:10.1093/imammb/dqw003
6.
go back to reference D. Cioranescu, P. Donato, An Introduction to Homogenization (Oxford University Press, Oxford, 1999)MATH D. Cioranescu, P. Donato, An Introduction to Homogenization (Oxford University Press, Oxford, 1999)MATH
7.
go back to reference A. Damlamian, P. Donato, Which sequences of holes are admissible for periodic homogenization with Neumann boundary condition? ESAIM: COCV 8, 555–585 (2002)MathSciNetCrossRefMATH A. Damlamian, P. Donato, Which sequences of holes are admissible for periodic homogenization with Neumann boundary condition? ESAIM: COCV 8, 555–585 (2002)MathSciNetCrossRefMATH
8.
go back to reference R.L. Drake, A general mathematical survey of the coagulation equation, in Topics in Current Aerosol Research (Part 2). International Reviews in Aerosol Physics and Chemistry (Pergamon Press, Oxford, 1972) R.L. Drake, A general mathematical survey of the coagulation equation, in Topics in Current Aerosol Research (Part 2). International Reviews in Aerosol Physics and Chemistry (Pergamon Press, Oxford, 1972)
9.
go back to reference B. Franchi, S. Lorenzani, From a microscopic to a macroscopic model for Alzheimer disease: two-scale homogenization of the Smoluchowski equation in perforated domains. J. Nonlin. Sci. 26, 717–753 (2016)MathSciNetCrossRefMATH B. Franchi, S. Lorenzani, From a microscopic to a macroscopic model for Alzheimer disease: two-scale homogenization of the Smoluchowski equation in perforated domains. J. Nonlin. Sci. 26, 717–753 (2016)MathSciNetCrossRefMATH
10.
go back to reference S. Giannuzzi, Equazione di Smoluchowski a coefficienti variabili e applicazioni. Master Thesis, School of Mathematics, University of Bologna (2015) S. Giannuzzi, Equazione di Smoluchowski a coefficienti variabili e applicazioni. Master Thesis, School of Mathematics, University of Bologna (2015)
11.
go back to reference O.A. Ladyzenskaja, V.A. Solonnikov, N.N. Ural’ceva, Linear and Quasi-Linear Equations of Parabolic Type (American Mathematical Society, Providence, RI, 1968) O.A. Ladyzenskaja, V.A. Solonnikov, N.N. Ural’ceva, Linear and Quasi-Linear Equations of Parabolic Type (American Mathematical Society, Providence, RI, 1968)
12.
go back to reference P. Laurençot, S. Mischler, Global existence for the discrete diffusive coagulation-fragmentation equations in L 1. Rev. Mat. Iberoamericana 18, 731–745 (2002)MathSciNetCrossRefMATH P. Laurençot, S. Mischler, Global existence for the discrete diffusive coagulation-fragmentation equations in L 1. Rev. Mat. Iberoamericana 18, 731–745 (2002)MathSciNetCrossRefMATH
13.
go back to reference G.M. Lieberman, Second Order Parabolic Differential Equations (World Scientific Publisher, Singapore, 1996)CrossRefMATH G.M. Lieberman, Second Order Parabolic Differential Equations (World Scientific Publisher, Singapore, 1996)CrossRefMATH
14.
go back to reference R.M. Murphy, M.M. Pallitto, Probing the kinetics of β-amyloid self-association. J. Struct. Biol. 130, 109–122 (2000)CrossRef R.M. Murphy, M.M. Pallitto, Probing the kinetics of β-amyloid self-association. J. Struct. Biol. 130, 109–122 (2000)CrossRef
15.
go back to reference G. Nguetseng, A general convergence result for a functional related to the theory of homogenization. SIAM J. Math. Anal. 20, 608–623 (1989)MathSciNetCrossRefMATH G. Nguetseng, A general convergence result for a functional related to the theory of homogenization. SIAM J. Math. Anal. 20, 608–623 (1989)MathSciNetCrossRefMATH
17.
go back to reference M. Smoluchowski, Versuch einer mathematischen theorie der koagulationskinetik kolloider lsungen. IZ Phys. Chem. 92, 129–168 (1917) M. Smoluchowski, Versuch einer mathematischen theorie der koagulationskinetik kolloider lsungen. IZ Phys. Chem. 92, 129–168 (1917)
18.
go back to reference D. Wrzosek, Existence of solutions for the discrete coagulation-fragmentation model with diffusion. Topol. Methods Nonlin. Anal. 9 (2), 279–296 (1997)MathSciNetMATH D. Wrzosek, Existence of solutions for the discrete coagulation-fragmentation model with diffusion. Topol. Methods Nonlin. Anal. 9 (2), 279–296 (1997)MathSciNetMATH
Metadata
Title
Smoluchowski Equation with Variable Coefficients in Perforated Domains: Homogenization and Applications to Mathematical Models in Medicine
Authors
Bruno Franchi
Silvia Lorenzani
Copyright Year
2017
DOI
https://doi.org/10.1007/978-3-319-52742-0_4

Premium Partner