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24-08-2020 | Original Paper

Sulfated xanthan: synthesis, characterization and biological evaluation

Authors: Sayyid Mahdi Rafigh, Atrin Rahimpour Soleymani, Amir Heydarinasab

Published in: Polymer Bulletin | Issue 9/2021

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Abstract

In this study, sulfated derivatives of xanthan gum (XG) were synthesized and then characterized using FTIR, ¹H NMR, ¹³C NMR, GPC, DSC, TGA, SEM, HPLC, Zeta (ζ) potential and elemental analysis. The degrees of substitution (DS) was 0.51 (SXG-1) and 1.23 (SXG-2). From the NMR spectrum and methylation analysis by GC–MS, it was concluded that the sulfate groups had completely introduced into the C-6 hydroxyl groups. The native XG and SXGs were further evaluated for their anticoagulant, antithrombotic and cytotoxic activities. The results suggest that the SXG-2 could be used as a promising anticoagulant and antithrombotic agent for clinical applications.

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Title: Sulfated xanthan: synthesis, characterization and biological evaluation
Authors: Sayyid Mahdi Rafigh
Atrin Rahimpour Soleymani
Amir Heydarinasab
Publication date: 24-08-2020
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 9/2021
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-020-03344-8

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