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Medical & Biological Engineering & Computing

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01-06-2011 | Technical Note

Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses

Published in: Medical & Biological Engineering & Computing | Issue 6/2011

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Abstract

Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.

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Title: Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses
Publication date: 01-06-2011
Published in: Medical & Biological Engineering & Computing / Issue 6/2011
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-011-0745-z

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