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Polymer Bulletin

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31-03-2016 | Original Paper

Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel

Authors: Chengyi Wu, Dandan Wang, Huimin Wu, Youmeng Dan

Published in: Polymer Bulletin | Issue 12/2016

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Abstract

In this manuscript, the novel sodium alginate-g-poly [acrylic acid–N-(3-dimethylaminopropyl) methyl acrylamide] [NaAlg-g-P(AA-co-DMAPMA)] hydrogel was prepared using free radical polymerization. Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), point zero charge and scanning electron microscopy were used to investigate the structure, thermal stability, surface charge and microstructure of the hydrogel. The factors that affected the swelling ratio of the hydrogel were investigated in detail, such as pH and ionic strength; the results showed that the hydrogel has a favorable pH-sensitive property. To investigate drug loading and sustained release of NaAlg-g-P(AA-co-DMAPMA), rhodamine B as a model drug was loaded on NaAlg-g-P(AA-co-DMAPMA). The in vitro drug release study conducted at pH 1.86 and 6.86 shows that NaAlg-g-P(AA-co-DMAPMA) was suitable for colon-specific drug delivery systems.

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Jaiswai M, Koul V (2013) Assessment of multicomponent hydrogel scaffolds of poly(acrylic acid-2-hydroxy ethyl methacrylate)/gelatin for tissue engineering applications. J Biomater Appl 27:848–861CrossRef

Yin W, Su R, Qi W, He Z (2012) A casein-polysaccharide hybrid hydrogel cross-linked by transglutaminase for drug delivery. J Mater Sci 47:2045–2055CrossRef

Biswas CS, Sulu E, Hazer B (2015) Effect of the composition of methanol-water mixtures on tacticity of poly (N-ethylacrylamide) gel. J Appl Polym Sci 132:41668–41678

Khademhosseini A, Langer R (2007) Review: microengineered hydrogel for tissue engineering. Biomaterials 28:5087–5092CrossRef

Biswas CS, Hazer B (2015) Synthesis and characterization of stereoregular poly(N-ethylacrylamide) hydrogel by using Y(OTf)₃ Lewis acid. Colloid Polym Sci 293:143–152CrossRef

Şanal T, Oruç O, Öztürk T, Hazer B (2015) Synthesis of pH- and Thermo-responsive Poly(ε-Caprolactone-b-4-vinyl benzyl-g-dimethyl amino ethyl methacrylate) Brush Graft Copolymers via RAFT Polymerization. J Polym Res 22(3):1–12

Jaiswal M, Gupta A, Dinda AK, Koul V (2010) Polycaprolactone diacrylate (PCL-DAr) crosslinked biodegradable semi-interpenetrating networks (semi-IPNs) of polyacrylamide and gelatin for controlled drug delivery. Biomed Mater 5:065014CrossRef

Shamunga Sudar S, Sangeetha D (2012) Investigation on sulphonated PEEK beads for drug delivery, bioactivity and tissue engineering applications. J Mater Sci 47:2736–2742CrossRef

Rajesh N, Siddaramaiah (2009) Feasibility of xanthan gum–sodium alginate as a transdermal drug delivery system for domperidone. J Mater Sci Mater Med 20(10):2085–2089CrossRef

10.

Agnihotri SA, Kulkarni RV, Nadagouda NM, Kulkarni PV, Aminabhavi TM (2005) Electrically modulated transport of diclofenac salts through hydrogel of sodium alginate, carbopol, and their blend polymers. J Appl Polym Sci 96(2):301–311CrossRef

11.

Hua S, Ma H, Li X, Yang H, Wang A (2010) pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca²⁺ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 46(5):517–523CrossRef

12.

Bagheri Marandi G, Sharifnia N, Hosseinzadeh H (2006) Synthesis of an alginate- poly(sodium acrylate-co-acrylamide) superabsorbent hydrogel with low salt sensitivity and high pH sensitivity. J Appl Polym Sci 101:2927–2937CrossRef

13.

Lang YY, Jiang TY, Li SM, Zheng LY (2008) Study on physicochemical properties of thermosensitive hydrogel constructed using graft-copolymers of poly(N-iso- propylacrylamide) and guar gum. J Appl Polym Sci 108(6):3473–3479CrossRef

14.

Gao CM, Liu MZ, Chen J, Chen C (2012) pH- and temperature-responsive P(DMAEMA-GMA)-Alginate semi-IPN hydrogel formed by radical and ring- opening polymerization for aminophylline release. J Biomat Sci Polym E 23:1039–1054CrossRef

15.

Demirel GB, Caykara T, Demiray M, Gürü M (2009) Effect of pore-forming agent type on swelling properties of macroporous poly(N-[3-(dimethylaminopropyl)]-methacrylamide-co-acrylamide) hydrogel. J Macromol Sci Part A Pure Appl Chem 46:58–64CrossRef

16.

Mall ID, Srivastava VC, Kumar GVA, Mishra IM (2006) Characterization and utilization of mesoporous fertilizer plant waste carbon for adsorptive removal of dyes from aqueous solution. Colloid Surf A 278:175–187CrossRef

17.

Kulkarni RV, Sreedhar V, Mutalik S, Setty CM, Sa B (2010) Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin. Int J Biol Macromol 47:520–527CrossRef

18.

Zhou C, Wu Q (2011) A novel polyacrylamide nanocomposite hydrogel reinforced with natural chitosan nanofibers. Colloids Surf B 84:155–162CrossRef

19.

Pachuaua L, Mazumder B (2012) Albizia procera gum as an excipient for oral controlled release matrix tablet. Carbohydr Polym 90:289–295CrossRef

20.

Wang XF, Sun XW, Liu WX, Gong BY, Gao NB (2008) Chitosan hydrogel beads for fulvic acid adsorption: behaviors and mechanisms. Chem Eng J 142:239–247CrossRef

21.

Pechenyuk SI (1999) The use of the pH at the point of zero charge for characterizing the properties of oxide hydroxides. Russ Chem B 48:1017–1023CrossRef

22.

Buchholz FL, Fredric L, Peppas NA (eds) (1994) Superabsorbent polymers: science and technology: developed from a symposium sponsored by the division of polymeric materials: science and engineering. ACS Symposium Series 573. American Chemical Society, Washington, DC

23.

Kasgoz H, Durmus A (2008) Dye removal by a novel hydrogel-clay nanocomposite with enhanced swelling properties. Polym Adv Technol 19:838–845CrossRef

24.

Gao TP, Wang WB, Wang AQ (2011) A pH-sensitive composite hydrogel based on sodium alginate and medical stone: synthesis, swelling, and heavy metal ions adsorption properties. Macromol Res 19(7):739–748CrossRef

25.

Park SE, Nho YC, Lim YM, Kim H (2004) Preparation of pH-sensitive poly(vinyl alcohol-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogel by gamma ray irradiation and their insulin release behavior. J Appl Polym Sci 91:636–643CrossRef

Title: Synthesis and characterization of macroporous sodium alginate-g-poly(AA-co-DMAPMA) hydrogel
Authors: Chengyi Wu
Dandan Wang
Huimin Wu
Youmeng Dan
Publication date: 31-03-2016
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 12/2016
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-016-1653-z

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