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Polymer Bulletin

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01-01-2012 | Original Paper

Synthesis and self-assembly of pH-responsive amphiphilic poly(ε-caprolactone)-block-poly(acrylic acid) copolymer

Authors: Cuizhen Li, Chunhua Gu, Yan Zhang, Meidong Lang

Published in: Polymer Bulletin | Issue 1/2012

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Abstract

The pH-responsive amphiphilic poly(ε-caprolactone)-block-poly(acrylic acid) (PCL-b-PAA) copolymer was prepared by selective hydrolysis of one novel poly(ε-caprolactone)-block-poly(methoxymethyl acrylate) (PCL-b-PMOMA) block copolymer, which was synthesized by combining ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and atom transfer radical polymerization (ATRP) of methoxymethyl acrylate (MOMA). Selective hydrolysis of the hemiketal ester groups on the PMOMA block gave 100% deprotection without the cleavage of the PCL block. The self-assembly behavior of PCL-b-PAA was investigated by fluorescence spectroscopy, DLS and TEM. The spherical micelles were formed with the hydrophobic PCL block as the core and the hydrophilic PAA as the shell by a co-solvent evaporation method. Moreover, the size and size distribution of the micelles varied with pH value and ionic strength in aqueous solution. The cytotoxicity of the PCL-b-PAA was lower, which was confirmed by MTT assay.

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Title: Synthesis and self-assembly of pH-responsive amphiphilic poly(ε-caprolactone)-block-poly(acrylic acid) copolymer
Authors: Cuizhen Li
Chunhua Gu
Yan Zhang
Meidong Lang
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Polymer Bulletin / Issue 1/2012
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-011-0520-1

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