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Journal of Sol-Gel Science and Technology
Published in: Journal of Sol-Gel Science and Technology 3/2019

08-07-2019 | Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications

The impact of copper oxide nanoparticles on the structure and applicability of bioactive glasses

Authors: K. Magyari, Zs. Pap, Z. R. Tóth, Zs. Kása, E. Licarete, D. C. Vodnar, K. Hernadi, L. Baia

Published in: Journal of Sol-Gel Science and Technology | Issue 3/2019

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Abstract

In order to identify novel appropriate compositions for targeted tissue engineering applications, bioactive glasses with copper oxide content were synthesized by sol-gel method and further investigated. Copper oxide nanoparticles (Cu2ONP) were chosen with the aim of understanding the impact of different copper species on the biocompatibility and antibacterial activity. The structural analyses revealed that the copper in the glass samples is in the copper hydroxy phosphate form, i.e., Cu2(PO4)(OH). The in vitro bioactivity assessment revealed that in the simulated body fluid were leached ionic species as CuH2PO4+, which interact with biological materials. In vitro cells viability assays performed with Human keratinocytes cells show good proliferation rate for the sample with 0.2 mol% CuO. The good antibacterial effect was obtained against Pseudomonas aeruginosa using glasses with 0.2–0.5 mol% CuO, and against Staphylococcus aureus, where only the sample with 0.5 mol% CuO exhibited a slight effect.
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Metadata
Title
The impact of copper oxide nanoparticles on the structure and applicability of bioactive glasses
Authors
K. Magyari
Zs. Pap
Z. R. Tóth
Zs. Kása
E. Licarete
D. C. Vodnar
K. Hernadi
L. Baia
Publication date
08-07-2019
Publisher
Springer US
Published in
Journal of Sol-Gel Science and Technology / Issue 3/2019
Print ISSN: 0928-0707
Electronic ISSN: 1573-4846
DOI
https://doi.org/10.1007/s10971-019-05066-4

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