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Published in:
Physical Properties of Carbon Nanotubes for Therapeutic Applications Read chapter Read first chapter

2011 | OriginalPaper | Chapter

Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes

Authors : V. Neves, H. M. Coley, J. McFadden, S. R. P. Silva

Published in: Carbon Nanotubes for Biomedical Applications

Publisher: Springer Berlin Heidelberg

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Abstract

Carbon nanotubes (CNTs) exhibit unique size, shape and physical properties, which make them promising candidates for biomedical applications. In particular, carbon nanotubes have been intensively studied for conjugation with pre-existing therapeutic agents for more effective targeting, as a result of their ability to cross cell membranes. However, to utilise them effectively in biological systems it is extremely important to understand how they behave at the cellular level and their distribution in vivo. Additionally, in order to consider carbon nanotubes as candidate delivery systems of therapeutic agents it is important to ascertain their fate in vivo, but also take into account many factors, such as solubility, stability and clearance. Issues surrounding their short term and long term safety are currently the subject of toxicology testing. Herein, we propose to summarize the main findings on the uptake, trafficking and biodistribution of carbon nanotubes, with special focus on functionalized carbon nanotubes for delivery of therapeutic agents.

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previous chapter Exploring Carbon Nanotubes and Their Interaction with Cells Using Atomic Force Microscopy
next chapter Recognition of Carbon Nanotubes by the Human Innate Immune System
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Metadata
Title
Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes
Authors
V. Neves
H. M. Coley
J. McFadden
S. R. P. Silva
Copyright Year
2011
Publisher
Springer Berlin Heidelberg
Book
Carbon Nanotubes for Biomedical Applications

Print ISBN: 978-3-642-14801-9

Electronic ISBN: 978-3-642-14802-6

Copyright Year: 2011

DOI
https://doi.org/10.1007/978-3-642-14802-6_9