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Polymer Bulletin
Published in: Polymer Bulletin 10/2023

30-11-2022 | ORIGINAL PAPER

A sandwich electrospun nanofibers/Tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine as a wound dressing

Authors: Hosna Alvandi, Mehdi Jaymand, Marie Eskandari, Faranak Aghaz, Leila Hosseinzadeh, Mohammadbagher Heydari, Elham Arkan

Published in: Polymer Bulletin | Issue 10/2023

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Abstract

In the present study, a sandwich electrospun nanofibers/tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine was prepared. The potential application was considered as a wound dressing. The first layer was prepared from polyacrylonitrile (PAN) by electrospinning method with thick diameter. The second layer was prepared by spraying a thin layer of tragacanth gum (TG) hydrogel containing silver sulfadiazine (SSD) and Aloe vera (AV) on the electrospun nanofibers. The properties of the electrospun nanofibers were evaluated by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). In addition, other properties such as mechanical properties, swelling ratio, cell viability were evaluated. SEM micrographs show smooth, beadles nanofibers, and a uniform layer of hydrogel was sprayed on the nanofibers. Adding 10% Aloe vera to TG increased the percentage of swelling compared to unmodified samples. Nanofibers have strong mechanical properties. The Young’s modulus of sandwich dressing was increased. The cytotoxicity assay of a sandwich electrospun nanofibers/tragacanth hydrogel composite shows that it has no cytotoxicity toward human dermal fibroblasts (HDF), therefore confirming their cytocompatibility.
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Metadata
Title
A sandwich electrospun nanofibers/Tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine as a wound dressing
Authors
Hosna Alvandi
Mehdi Jaymand
Marie Eskandari
Faranak Aghaz
Leila Hosseinzadeh
Mohammadbagher Heydari
Elham Arkan
Publication date
30-11-2022
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 10/2023
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-022-04603-6

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