Top

Cellulose

Published in:

16-11-2022 | Original Research

Different cellulose nanofibers impact properties of calcium phosphate silicate cement for bone tissue engineering

Authors: Tianxing Gong, Xiujuan Ji, Xinyu Liu, Jingqiu Zhou, Jingshu Zhang, Yadong Chen, Qiong Wu

Published in: Cellulose | Issue 2/2023

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Aging-related abnormal bone metabolism can have detrimental effects on bone microstructure and significantly increases fracture occurrence in the older population. Injectable bone cement has been commonly used to augment porous and fragile bones. The self-setting calcium phosphate silicate cement (CPSC) has recently been proven suitable for bone tissue engineering. Unfortunately, the inadequate mechanical properties of CPSC limit its utilization as implants for load-bearing applications. One primary purpose of this study is to improve the mechanical properties of CPSC using different cellulose nanofibers (CNFs). It is shown that the mechanical properties of CPSC could be enhanced by adding 2% mass fractions of CNFs, carboxylate CNFs (CNF-C) and silanized CNFs (CNF-SH), and the reinforcing effects on the mechanical property of CPSC could be ranked as CNF-SH > CNFs > CNF-C. In addition, the Young's modulus of the CPSC pellet modified with CNF-SH (~ 10 GPa) was proved to be close to that of trabecular bone (~ 11.4 GPa). Unlike other studies, where the mechanical properties of bone cement were improved at the cost of decreasing handleability, our approach could simultaneously increase both qualities of the CPSC paste. Furthermore, the in vitro biocompatibility analyses proved that the nanofiber-modified CPSC was biocompatible and encouraged the proliferation and differentiation of osteoblast cells. In summary, the injectable CPSC bone cement can be better enhanced by CNF-SH than CNFs or CNF-C, and the resultant nanofiber-reinforced bone cement is a promising candidate as a bone substitute biomaterial.

Graphical Abstract

previous article Nano-silica/hydroxypropyl methyl cellulose nanocomposite polymer thickener for excellent 240 °C sedimentation control performance of water-based drilling fluid

next article Study of the durability and sustainability of fluorescent nanosensors based on cellulose nanocomposites incorporated with various carbon dots

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

An J, Liao H, Kucko NW, Herber RP, Wolke JGC, van den Beucken JJ, Jansen JA, Leeuwenburgh SCG (2016) Long-term evaluation of the degradation behavior of three apatite-forming calcium phosphate cements. J Biomed Mater Res A 104:1072–1081. https://doi.org/10.1002/jbm.a.35641CrossRef

Bellows CG, Aubin JE, Heersche JNM, Antosz ME (1986) Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int 38:143–154. https://doi.org/10.1007/BF02556874CrossRef

Bohl DD, Sershon RA, Saltzman BM, Darrith B, Della Valle CJ (2018) Incidence, risk factors, and clinical implications of pneumonia after surgery for geriatric hip fracture. J Arthroplast 33:1552–1556. https://doi.org/10.1016/j.arth.2017.11.068CrossRef

Bohner M, Baroud G (2005) Injectability of calcium phosphate pastes. Biomaterials 26:1553–1563. https://doi.org/10.1016/j.biomaterials.2004.05.010CrossRef

Burguera EF, Xu HHK, Weir MD (2006) Injectable and rapid-setting calcium phosphate bone cement with dicalcium phosphate dihydrate. J Biomed Mater Res B Appl Biomater 77:126–134. https://doi.org/10.1002/jbm.b.30403CrossRef

Castro AGB, Polini A, Azami Z, Leeuwenburgh SCG, Jansen JA, Yang F, van den Beucken JJ (2017) Incorporation of PLLA micro-fillers for mechanical reinforcement of calcium-phosphate cement. J Mech Behav Biomed Mater 71:286–294. https://doi.org/10.1016/j.jmbbm.2017.03.027CrossRef

Collignon H, Davicco MJ, Barlet JP (1997) Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization. Arch Physiol Biochem 105:158–166. https://doi.org/10.1076/apab.105.2.158.12924CrossRef

Curvello R, Raghuwanshi VS, Garnier G (2019) Engineering nanocellulose hydrogels for biomedical applications. Adv Colloid Interface Sci 267:47–61. https://doi.org/10.1016/j.cis.2019.03.002CrossRef

de Lacerda SS, Pinto JC, Jansen J, Leeuwenburgh SCG, van den Beucken JJ (2020) Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study. Biomater Sci 8:4239–4250. https://doi.org/10.1039/D0BM00413HCrossRef

Deng M, Han J, Liu H, Qin M, Liang X (2015) Analysis of compressive toughness and deformability of high ductile fiber reinforced concrete. Adv Mater Sci Eng 2015:384902. https://doi.org/10.1155/2015/384902CrossRef

Faienza MF, Lassandro G, Chiarito M, Valente F, Ciaccia L, Giordano P (2020) How physical activity across the lifespan can reduce the impact of bone ageing: a literature review. Int J Environ Res Public Health 17:1862. https://doi.org/10.3390/ijerph17061862CrossRef

Faruq O, Sayed S, Kim B, Im SB, Lee BT (2020) A biphasic calcium phosphate ceramic scaffold loaded with oxidized cellulose nanofiber-gelatin hydrogel with immobilized simvastatin drug for osteogenic differentiation. J Biomed Mater Res B Appl Biomater 108:1229–1238. https://doi.org/10.1002/jbm.b.34471CrossRef

Gong T, Chen Y, Zhang Y, Zhang Y, Liu X, Troczynski T, Häfeli UO (2016a) Osteogenic and anti-osteoporotic effects of risedronate-added calcium phosphate silicate cement. Biomed Mater 11:045002. https://doi.org/10.1088/1748-6041/11/4/045002CrossRef

Gong T, Wang Z, Zhang Y, Zhang Y, Hou M, Liu X, Wang Y, Zhao L, Ruse ND, Troczynski T, Häfeli UO (2016b) A comprehensive study of osteogenic calcium phosphate silicate cement: material characterization and in vitro/in vivo testing. Adv Healthc Mater 5:457–466. https://doi.org/10.1002/adhm.201500469CrossRef

Gong T, Li T, Meng L, Chen Y, Wu T, Zhou J, Lu G, Wang Z (2022) Fabrication of piezoelectric Ca-P-Si-doped PVDF scaffold by phase-separation-hydration: material characterization, in vitro biocompatibility and osteoblast redifferentiation. Ceram Int 48:6461–6469. https://doi.org/10.1016/j.ceramint.2021.11.190CrossRef

Isogai A, Saito T, Fukuzumi H (2011) TEMPO-oxidized cellulose nanofibers. Nanoscale 3:71–85. https://doi.org/10.1039/C0NR00583ECrossRef

Kasugai S, Nagata T, Sodek J (1992) Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation in vitro. J Cell Physiol 152:467–477. https://doi.org/10.1002/jcp.1041520305CrossRef

Komori T (2018) Runx2, an inducer of osteoblast and chondrocyte differentiation. Histochem Cell Biol 149:313–323. https://doi.org/10.1007/s00418-018-1640-6CrossRef

Kucko NW, de Lacerda SS, Sobral Marques T, Herber RP, van den Beucken JJ, Zuo Y, Leeuwenburgh SCG (2019a) Tough and osteocompatible calcium phosphate cements reinforced with poly(vinyl alcohol) fibers. ACS Biomater Sci Eng 5:2491–2505. https://doi.org/10.1021/acsbiomaterials.9b00226CrossRef

Kucko NW, Li W, García-Martinez MA, Rehman IU, Ulset AT, Christensen BE, Leeuwenburgh SCG, Herber RP (2019b) Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly ((D, L) -lactic-co-glycolic acid) porogens and carboxymethyl cellulose. J Biomed Mater Res B Appl BiOmater 107:2216–2228. https://doi.org/10.1002/jbm.b.34306CrossRef

Kucko NW, Petre DG, de Ruiter M, Herber RP, Leeuwenburgh SCG (2020) Micro- and macromechanical characterization of the influence of surface-modification of poly(vinyl alcohol) fibers on the reinforcement of calcium phosphate cements. J Mech Behav Biomed Mater 109:103776. https://doi.org/10.1016/j.jmbbm.2020.103776CrossRef

Liu W, Zhang J, Weiss P, Tancret F, Bouler JM (2013) The influence of different cellulose ethers on both the handling and mechanical properties of calcium phosphate cements for bone substitution. Acta Biomater 9:5740–5750. https://doi.org/10.1016/j.actbio.2012.11.020CrossRef

Liu T, Cai C, Ma R, Deng Y, Tu L, Fan Y, Lu D (2021) super-hydrophobic cellulose nanofiber air filter with highly efficient filtration and humidity resistance. ACS Appl Mater Interfaces 13:24032–24041. https://doi.org/10.1021/acsami.1c04258CrossRef

Lou J, Xu F, Merkel K, Manske P (1999) Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J Orthop Res 17:43–50. https://doi.org/10.1002/jor.1100170108CrossRef

Madassery S (2020) Vertebral compression fractures: evaluation and management. Semin Intervent Radiol 37:214–219. https://doi.org/10.1055/s-0040-1709208CrossRef

Matinfar M, Mesgar AS, Mohammadi Z (2019) Evaluation of physicochemical, mechanical and biological properties of chitosan/carboxymethyl cellulose reinforced with multiphasic calcium phosphate whisker-like fibers for bone tissue engineering. Mater Sci Eng C Mater Biol Appl 100:341–353. https://doi.org/10.1016/j.msec.2019.03.015CrossRef

Shaban NZ, Kenawy MY, Taha NA, Abd El-Latif MM, Ghareeb DA (2021) cellulose acetate nanofibers: incorporating hydroxyapatite (ha), ha/berberine or ha/moghat composites, as scaffolds to enhance in vitro osteoporotic bone regeneration. Polymers (basel). https://doi.org/10.3390/polym13234140CrossRef

Suhm N, Gisep A (2008) Injectable bone cement augmentation for the treatment of distal radius fractures: a review. J Orthop Trauma 22:S121–S125. https://doi.org/10.1097/BOT.0b013e3181830d13CrossRef

Sun S, Wang Z, Hao Y (2008) Osterix overexpression enhances osteoblast differentiation of muscle satellite cells in vitro. Int J Oral Maxillofac Surg 37:350–356. https://doi.org/10.1016/j.ijom.2007.11.024CrossRef

Voicu G, Jinga SI, Drosu BG, Busuioc C (2017) Improvement of silicate cement properties with bacterial cellulose powder addition for applications in dentistry. Carbohydr Polym 174:160–170. https://doi.org/10.1016/j.carbpol.2017.06.062CrossRef

Zhang J, Tancret F, Bouler JM (2011) Fabrication and mechanical properties of calcium phosphate cements (CPC) for bone substitution. Mater Sci Eng, C 31:740–747. https://doi.org/10.1016/j.msec.2010.10.014CrossRef

Zhang Y, Wang D, Wang F, Jiang S, Shu Y (2015) Modification of dicalcium silicate bone cement biomaterials by using carboxymethyl cellulose. J Non-Cryst Solids 426:164–168. https://doi.org/10.1016/j.jnoncrysol.2015.07.014CrossRef

Zhang Q, Lei Z, Peng M, Zhong M, Wan Y, Luo H (2019) Enhancement of mechanical and biological properties of calcium phosphate bone cement by incorporating bacterial cellulose. Mater Technol 34:800–806. https://doi.org/10.1080/10667857.2019.1630951CrossRef

Zhao W, Wang J, Zhai W, Wang Z, Chang J (2005) The self-setting properties and in vitro bioactivity of tricalcium silicate. Biomaterial 26:6113–6121. https://doi.org/10.1016/j.biomaterials.2005.04.025CrossRef

Zysset PK, Guo XE, Hoffler CE, Moore KE, Goldstein SA (1999) Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J Biomech 32:1005–1012. https://doi.org/10.1016/s0021-9290(99)00111-6CrossRef

Title: Different cellulose nanofibers impact properties of calcium phosphate silicate cement for bone tissue engineering
Authors: Tianxing Gong
Xiujuan Ji
Xinyu Liu
Jingqiu Zhou
Jingshu Zhang
Yadong Chen
Qiong Wu
Publication date: 16-11-2022
Publisher: Springer Netherlands
Published in: Cellulose / Issue 2/2023
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-022-04942-7

Springer Professional

Abstract

Graphical Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Springer Professional "Wirtschaft+Technik"

Other articles of this Issue 2/2023

Development of energy efficient nanocellulose production process by enzymatic pretreatment and controlled temperature refining of cotton linters

MoS2@MIL-101(Fe) functionalized carboxylated loofah as a platform for the photodegradation of tetracycline and methylene blue from wastewater

Cellulose/β-cyclodextrin hydrogel supported metal nanoparticles as recyclable catalysts in the 4-nitrophenol reduction, Suzuki–Miyaura coupling and click reactions

Aqueous bifunctionalization of cellulose nanocrystals through amino and alkyl silylation: functionalization, characterization, and performance of nanocrystals in quartz microflotation

Immobilization of a cellulose carbamate-type chiral selector onto silica gel by alkyne-azide click chemistry for the preparation of chiral stationary chromatography phases

A sustainable approach to enhance flame retardant, antibacterial and UV resistance of lyocell fabrics treated with luffa phosphate derivatives and emodin