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Colloid and Polymer Science

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01-08-2011 | Original Contribution

Effects of cationic and anionic nanoparticles on the stability of the secondary structure of DNA

Authors: Hiroyuki Kamata, Anatoly Zinchenko, Shizuaki Murata

Published in: Colloid and Polymer Science | Issue 12/2011

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Abstract

The effects of anionic and cationic nanoparticles (15 and 100 nm in diameter) on the stability of the secondary structure of DNA were studied in DNA denaturation and renaturation processes. The results showed that DNA denaturation is greatly inhibited in the presence of cationic nanoparticles. In contrast, in the presence of even large amounts of anionic nanoparticles, the DNA melting transition occurs at the original melting temperature. The effects of the size and concentration of nanoparticles on DNA denaturation are discussed.

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The estimation is made based on dependence of ζ potential of NP on amino groups concentration reported previously [26]. NP100(+) and NP15(+) were compared with NP100L and NP15 in [26] respectively. The estimation error does not exceed 20%.

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Title: Effects of cationic and anionic nanoparticles on the stability of the secondary structure of DNA
Authors: Hiroyuki Kamata
Anatoly Zinchenko
Shizuaki Murata
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Colloid and Polymer Science / Issue 12/2011
Print ISSN: 0303-402X
Electronic ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-011-2453-5

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