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Continuum Mechanics and Thermodynamics
Published in: Continuum Mechanics and Thermodynamics 3/2023

25-04-2022 | Original Article

Experimental methods of living cells mechanical loading: review

Authors: Natalia Branecka, Tomasz Lekszycki

Published in: Continuum Mechanics and Thermodynamics | Issue 3/2023

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Abstract

Studying the effects of mechanical loads on living cells provides valuable information about their activity, vitality and intercellular communication. Mechanical stimuli have often a significant impact on cell migration, tissue remodeling and healing and other phenomena. This effects in micro scale affect also tissue structure, its mechanical characteristics and functionality. Special methods are needed to study deformation and biological responses of such small objects as cells. Moreover, in order to keep the cells alive during such tests, it is necessary to ensure appropriate environmental conditions. The methods of loading and examination cells can be categorized into several groups depending on the physical effects used in experiment. This paper provides a systematic review of the methods used in such studies and examples of mathematical modeling the mechanical response of cells to mechanical loads. Such models enable computational simulation of changes in cells and tissues excited by mechanical stress.
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Metadata
Title
Experimental methods of living cells mechanical loading: review
Authors
Natalia Branecka
Tomasz Lekszycki
Publication date
25-04-2022
Publisher
Springer Berlin Heidelberg
Published in
Continuum Mechanics and Thermodynamics / Issue 3/2023
Print ISSN: 0935-1175
Electronic ISSN: 1432-0959
DOI
https://doi.org/10.1007/s00161-022-01099-3

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