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18-11-2020 | Original Article

Fe₃O₄@Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance imaging

Authors: Kai Wang, Xiao-Guang Xu, Ying-Li Ma, Chun-Rui Sheng, Li-Na Li, Li-Ying Lu, Jian Wang, Yi-Ning Wang, Yong Jiang

Published in: Rare Metals | Issue 9/2021

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Abstract

Although iron oxide (Fe₃O₄) nanoparticles have broad application prospects as magnetic resonance imaging (MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe₃O₄@Angelica sinensis polysaccharide nanoparticles (Fe₃O₄@ASP NPs) with a 9 nm Fe₃O₄ core and ASP as the coating material. The Fe₃O₄@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time (T₂) and T₂-star (T₂*) magnetic resonance imaging (MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and the pathological tests in mice validate that Fe₃O₄@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe₃O₄@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo.

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Title: Fe3O4@Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance imaging
Authors: Kai Wang
Xiao-Guang Xu
Ying-Li Ma
Chun-Rui Sheng
Li-Na Li
Li-Ying Lu
Jian Wang
Yi-Ning Wang
Yong Jiang
Publication date: 18-11-2020
Publisher: Nonferrous Metals Society of China
Published in: Rare Metals / Issue 9/2021
Print ISSN: 1001-0521
Electronic ISSN: 1867-7185
DOI: https://doi.org/10.1007/s12598-020-01620-0

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