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Meccanica
Published in: Meccanica 3/2017

27-06-2016 | Advances in Biomechanics: from foundations to applications

Growth and remodeling of load-bearing biological soft tissues

Authors: C. J. Cyron, J. D. Humphrey

Published in: Meccanica | Issue 3/2017

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Abstract

The past two decades reveal a growing role of continuum biomechanics in understanding homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly review the two primary theoretical approaches for describing mechano-regulated soft tissue growth and remodeling on the continuum level as well as hybrid approaches that attempt to combine the advantages of these two approaches while avoiding their disadvantages. We also discuss emerging concepts, including that of mechanobiological stability. Moreover, to motivate and put into context the different theoretical approaches, we briefly review findings from mechanobiology that show the importance of mass turnover and the prestressing of both extant and new extracellular matrix in most cases of growth and remodeling. For illustrative purposes, these concepts and findings are discussed, in large part, within the context of two load-bearing, collagen dominated soft tissues—tendons/ligaments and blood vessels. We conclude by emphasizing further examples, needs, and opportunities in this exciting field of modeling soft tissues.
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Metadata
Title
Growth and remodeling of load-bearing biological soft tissues
Authors
C. J. Cyron
J. D. Humphrey
Publication date
27-06-2016
Publisher
Springer Netherlands
Published in
Meccanica / Issue 3/2017
Print ISSN: 0025-6455
Electronic ISSN: 1572-9648
DOI
https://doi.org/10.1007/s11012-016-0472-5

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