Top

Journal of Materials Science: Materials in Electronics

Published in:

05-04-2021

Investigation of cytotoxicity of superparamagnetic KFeO₂ nanoparticles on MCF-7 cell lines for biomedical applications

Authors: Ankush Kumar Tangra, Gurmeet Singh

Published in: Journal of Materials Science: Materials in Electronics | Issue 8/2021

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Superparamagnetic nanoparticles hold great potential for biomedical applications due to their exceptional properties. Biocompatible KFeO₂ superparamagnetic nanoparticles have been synthesized by the bottom-up approach. X-ray diffraction (XRD), transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), and cytotoxicity test by MTT assay have been performed to understand the structure, morphology, magnetic, and toxicity properties, respectively. XRD patterns have been indexed and refined by the Rietveld refinement and used to calculate the various structural parameters. XRD revealed the orthorhombic crystal structure of KFeO₂. TEM suggested that the average particle size of KFeO₂ nanoparticles is 13 nm with spherical morphology. The magnetic study discloses the superparamagnetic behavior of KFeO₂ nanoparticles. The toxicity of the KFeO₂ nanoparticles has been analyzed by MTT revealed their high cell viability. The various factors responsible for the toxicity of nanoparticles along with the incorporation and degradation mechanism of the nanoparticles have been presented.

previous article Mentha piperita-mediated synthesis of cobalt aluminate nanoparticles and their photocatalytic activity

next article Fabrication, characterization, and malaria biomarker VOC-sensing properties of WO3-doped polyaniline

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

G.S. Lotey, N.K. Verma, Structural, magnetic, and electrical properties of Gd-doped BiFeO₃ nanoparticles with reduced particle size. J. Nanopart. Res. 14(3), 742 (2012)CrossRef

B.S. Randhawa, H.S. Dosanjh, N. Kumar, Synthesis of potassium ferrite by precursor and combustion methods. J. Therm. Anal. Calorim. 95(1), 75–80 (2009)CrossRef

S.C. Han, W.B. Park, K.S. Sohn, M. Pyo, KFeO₂ with corner-shared FeO₄ frameworks as a new type of cathode material in potassium-ion batteries. J. Solid State Electrochem. 23(11), 3135–3143 (2019)CrossRef

L. Khanna, N.K. Verma, S.K. Tripathi, Burgeoning tool of biomedical applications-superparamagnetic nanoparticles. J. Alloys Compd. 752, 332–353 (2018)CrossRef

Z. Tomkowicz, A. Szytuła, Crystal and magnetic structure of KFeO₂. J. Phys. Chem. Solids 38(10), 1117–1123 (1977)CrossRef

M. Kim, B.H. Kim, H.C. Choi, B.I. Min, Origin of high Néel temperature in the low coordination number system AFeO₂ (A= K and Rb). Phys. Rev. B 81(21), 212405 (2010)CrossRef

U. Shimony, J.M. Knudsen, Mössbauer studies on iron in the perovskites La_1–xSr_xFeO₃ (0 <~ x<~ 1). Phys. Rev. 144(1), 361 (1966)CrossRef

G. Singh, T.P. Kaur, A.K. Tangra, Novel KFeO₂ nanoparticles for dye-sensitized solar cell. Mater. Res. Express 6(11), 1150f5 (2019)CrossRef

A.K. Tangra, S. Singh, N.X. Sun, G.S. Lotey, Investigation of structural, Raman and photoluminescence properties of novel material: KFeO₂ nanoparticles. J. Alloys Compd. 778, 47–52 (2019)CrossRef

10.

A.K. Tangra, S. Singh, G. Singh, Investigation of the magnetic behavior of the ferrites of alkali and alkaline earth metals for biomedical application. Mater. Today Proc. 36 (3), 621–625 (2021)CrossRef

11.

S. Singh, A.K. Tangra, G. Singh, Optical and luminescence properties of β-NaFeO₂ nanoparticles. Electron. Mater. Lett. 14(5), 594–598 (2018)CrossRef

12.

N. Ali, J. Zafar, D. Nuss, M.J. Sheptyakov, The AFeO₂ (A= K, Rb and Cs) family: a comparative study of structures and structural phase transitions. J. Solid State Chem. 183(3), 752–759 (2010)CrossRef

13.

S.J. Moon, I.B. Shim, C.S. Kim, Crystallographic and magnetic properties of KFeO₂. IEEE Trans. Magn. 42(10), 2879–2881 (2006)CrossRef

14.

J. Nuss, N.Z. Ali, M. Jansen, Structure of RbFeO₂, refined from a reticular pseudomerohedrally twinned crystal with six domains. Acta Crystallogr. B 63(5), 719–725 (2007)CrossRef

15.

H.Y. Chen, J.H. Wu, Transparent conductive CuFeO₂ thin films prepared by sol-gel processing. Appl. Surf. Sci. 258(11), 4844–4847 (2012)CrossRef

16.

D. Taylor, The structural behaviour of tetrahedral framework compounds—a review. Part II. Framework structures. Mineral. Mag. 48(346), 65–79 (1984)CrossRef

17.

J.K. Vassiliou, V. Mehrotra, M.W. Russell, E.P. Giannelis, R.D. McMichael, R.D. Shull, R.F. Ziolo, Magnetic and optical properties of γ-Fe₂O₃ nanocrystals. J. Appl. Phys. 73(10), 5109–5116 (1993)CrossRef

18.

E.P. Giannelis, V. Mehrotra, J.K. Vassiliou, R.D. Shull, R.D. MacMichael, R.F. Ziolo, Magnetic and optical properties of γ-Fe₂O₃ nanocrystals. Nanophase Mater. 260, 617–624 (1994)CrossRef

19.

C. Li, A.F. Reid, S. Saunders, Nonstoichiometric alkali ferrites and aluminates in the systems NaFeO₂ TiO₂, KFeO₂ TiO₂, KAlO_2, TiO₂, and KAlO₂ SiO₂. J. Solid State Chem. 3, 614–620 (1971)CrossRef

20.

A.V. Zalesskii, A.A. Frolov, T.A. Khimich, A.A. Bush, Composition-induced transition of spin-modulated structure into a uniform antiferromagnetic state in a Bi_1−xLa_xFeO₃ system studied using 57Fe NMR. Phys. Solid State 45(1), 141–145 (2003)CrossRef

21.

E. Mugnier, A. Barnabé, L. Presmanes, P. Tailhades, Thin films preparation by rf-sputtering of copper/iron ceramic targets with Cu/Fe1 From nanocomposites to delafossite compounds. Thin Solid Films 516(7), 1453–1456 (2008)CrossRef

22.

M. Arruebo, R. Fernández-Pacheco, M.R. Ibarra, J. Santamaría, Magnetic nanoparticles for drug delivery. Nano Today 2, 22 (2007)CrossRef

23.

B. Issa, I.M. Obaidat, A. Borhan, Y.H. Albiss, Magnetic nanoparticles: surface effects and properties related to biomedicine applications. Int. J. Mol. Sci. 14(11), 21266–21305 (2013)CrossRef

24.

Y.P. He, S.Q. Wang, C.R. Li, Y.M. Miao, Z.Y. Wu, B.S. Zou, Synthesis and characterization of functionalized silica-coated Fe₃O₄ superparamagnetic nanocrystals for biological applications. J. Phys. D 38(9), 1342 (2005)CrossRef

25.

J.I. Gittleman, B. Abeles, S. Bozowski, Superparamagnetism and relaxation effects in granular Ni-SiO₂ and Ni-Al₂O₃ films. Phys. Rev. B 9(9), 3891 (1974)CrossRef

26.

M. Aneja, A. Tovstolytkin, G.S. Lotey, Superparamagnetic LaSrMnO₃ nanoparticles for magnetic nanohyperthermia and their biocompatibility. J. Magn. Magn. Mater. 442, 423–428 (2017)CrossRef

27.

S. Singh, J. Kaur, A. Tovstolytkin, G. Singh, Superparamagnetic β-NaFeO₂: a novel, efficient and biocompatible nanoparticles for treatment of cancer by nanohyperthermia. Mater. Res. Express 6(8), 0850a6 (2019)CrossRef

28.

A. Sukhanova, S. Bozrova, P. Sokolov, M. Berestovoy, A. Karaulov, I. Nabiev, Dependence of nanoparticle toxicity on their physical and chemical properties. Nanoscale Res. Lett. (2018). https://doi.org/10.1186/s11671-018-2457-xCrossRef

29.

G.S. Zamay, T.N. Zamay, K.A. Lukyanenko, A.S. Kichkailo, Aptamers increase biocompatibility and reduce the toxicity of magnetic nanoparticles used in biomedicine. Biomedicines 8(3), 59 (2020)CrossRef

30.

S. Briceño, A.C. Hernandez, J. Sojo, L. Lascano, G. Gonzalez, Degradation of magnetite nanoparticles in biomimetic media. J. Nanopart. Res. 19, 1–10 (2017)CrossRef

Title: Investigation of cytotoxicity of superparamagnetic KFeO2 nanoparticles on MCF-7 cell lines for biomedical applications
Authors: Ankush Kumar Tangra
Gurmeet Singh
Publication date: 05-04-2021
Publisher: Springer US
Published in: Journal of Materials Science: Materials in Electronics / Issue 8/2021
Print ISSN: 0957-4522
Electronic ISSN: 1573-482X
DOI: https://doi.org/10.1007/s10854-021-05793-x

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Springer Professional "Wirtschaft"

Other articles of this Issue 8/2021

Surface crystallization of BiOCl on 2Bi2O3–B2O3 glasses for photocatalytic applications

Influence of graphene concentration towards the thermo-acoustic and vibrational properties of graphene: polyvinyl alcohol composites

Band gap narrowing and electrical properties of (1-x)BaTiO3-xSrFe0.5Nb0.5O3 lead-free ceramics

Gold-embedded fabrication of three-dimensional ordered macroporous TiO2 via in-situ pyrolysis for enhanced photocatalysis

The effect of electrodeposition applied potential on the electrochemical performance of polyaniline films

Influence of synthetic parameters on the enhanced photocatalytic properties of ZnO nanoparticles for the degradation of organic dyes: a green approach