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IEEE 754 Floating Point Pipelined Multiplier with Karatsuba for Mitigations of Area and Power Read chapter Read first chapter

2021 | OriginalPaper | Chapter

Modeling and Simulation of p53-Mdm2 Protein Pathway in Normal Cells

Authors : Trisha Patra, Sanghamitra Chatterjee, Soumya Pandit, Soma Barman (Mandal)

Published in: Computers and Devices for Communication

Publisher: Springer Singapore

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Abstract

The p53, “Guardian of Genome,” is a special type of protein acting as a tumor suppressor and transcription factor for Mdm2. The interaction between p53-Mdm2 protein pathway forms a negative feedback network where p53 activates Mdm2 and Mdm2 deactivates p53 through ubiquitination. The interaction between p53-Mdm2 plays an important role in cancer progression. In this paper, ordinary differential equation (ODE) is derived based on mass action kinetics of the chemical reactions of the protein pathway under normal condition of DNA. A system model of p53-Mdm2 pathway is derived for normal cells using Michealis-Menten kinetics. The system model describing the dynamics of the pathway is simulated in MATLAB R2014a environment.

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previous chapter Identification of Satellite DNA in Different Species
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Metadata
Title
Modeling and Simulation of p53-Mdm2 Protein Pathway in Normal Cells
Authors
Trisha Patra
Sanghamitra Chatterjee
Soumya Pandit
Soma Barman (Mandal)
Copyright Year
2021
Publisher
Springer Singapore
Book
Computers and Devices for Communication

Print ISBN: 978-981-15-8365-0

Electronic ISBN: 978-981-15-8366-7

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-981-15-8366-7_10