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Journal of Nanoparticle Research

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01-11-2017 | Review

MRI based on iron oxide nanoparticles contrast agents: effect of oxidation state and architecture

Authors: Yasir Javed, Kanwal Akhtar, Hafeez Anwar, Yasir Jamil

Published in: Journal of Nanoparticle Research | Issue 11/2017

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Abstract

Iron oxide nanoparticles (IONPs) extensively employed beyond regenerative medicines to imaging disciplines because of their great constituents for magneto-responsive nano-systems. The unique superparamagnetic behavior makes IONPs very suitable for hyperthermia and imaging applications. From the last decade, versatile functionalization with surface capabilities, efficient contrast properties and biocompatibilities make IONPs an essential imaging contrast agent for magnetic resonance imaging (MRI). IONPs have shown signals for both longitudinal relaxation and transverse relaxation; therefore, negative contrast as well as dual contrast can be used for imaging in MRI. In the current review, we have focused on different oxidation state of iron oxides, i.e., magnetite, maghemite and hematite for their T₁ and T₂ contrast enhancement properties. We have also discussed different factors (synthesis protocols, biocompatibility, toxicity, architecture, etc.) that can affect the contrast properties of the IONPs.

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Aggarwal P, Hall JB et al (2009) Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 61(6):428–437CrossRef

Albornoz C, Sileo EE et al (2004) Magnetic polymers of maghemite (γ-Fe₂O₃) and polyvinyl alcohol. Phys B Condens Matter 354(1):149–153CrossRef

Alexiou C, Jurgons R et al (2006) Medical applications of magnetic nanoparticles. J Nanosci Nanotechnol 6(9-10):2762–2768CrossRef

Arshad M, Siddiqui HA et al (2016) Synthesis of iron oxide magnetic nanoparticle by sol-gel method and their characterization. Professor Dr. Muhammad Tufail Convener 98:98

Azhdarzadeh M, Atyabi F et al (2016) Theranostic MUC-1 aptamer targeted gold coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and photothermal therapy of colon cancer. Colloids Surf B Biointerfaces 143:224–232CrossRef

Ba-Abbad MM, Takriff MS et al (2017) Size and shape controlled of α-Fe2O3 nanoparticles prepared via sol–gel technique and their photocatalytic activity. J Sol-Gel Sci Technol 81(3):880–893CrossRef

Baaziz W, Pichon BP et al (2014) Magnetic iron oxide nanoparticles: reproducible tuning of the size and nanosized-dependent composition, defects, and spin canting. J Phys Chem C 118(7):3795–3810CrossRef

Bae KH, Kim YB et al (2010) Bioinspired synthesis and characterization of gadolinium-labeled magnetite nanoparticles for dual contrast T 1-and T 2-weighted magnetic resonance imaging. Bioconjug Chem 21(3):505–512CrossRef

Bagwe R, Kanicky J et al (2001) Improved drug delivery using microemulsions: rationale, recent progress, and new horizons. Crit Rev Ther Drug Carrier Syst 18(1):77

Basak S, Chen D-R et al (2007) Electrospray of ionic precursor solutions to synthesize iron oxide nanoparticles: modified scaling law. Chem Eng Sci 62(4):1263–1268CrossRef

Bashir M, Riaz S et al (2014) Magnetic Properties of Fe 3 O 4 Stabilized Zirconia. IEEE Trans Magn 50(8):1–4CrossRef

Basti H, Tahar LB et al (2010) Catechol derivatives-coated Fe 3 O 4 and γ-Fe 2 O 3 nanoparticles as potential MRI contrast agents. J Colloid Interface Sci 341(2):248–254CrossRef

Beg MS, Mohapatra J et al (2017) Porous Fe 3 O 4-SiO 2 core-shell nanorods as high-performance MRI contrast agent and drug delivery vehicle. J Magn Magn Mater 428:340–347CrossRef

Bermudez E, Mangum JB et al (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77(2):347–357CrossRef

Bhavani P, Rajababu C et al (2016) Synthesis and characterization of iron oxide nanoparticles prepared hydrothermally at different reaction temperatures and pH. Int J Mater Res 107(10):942–947CrossRef

Bhosale RR, Kumar A et al (2016) Propylene oxide assisted sol–gel synthesis of zinc ferrite nanoparticles for solar fuel production. Ceram Int 42(2):2431–2438CrossRef

Bhosale RR, Shende RV et al (2012) Sol-gel derived NiFe 2 O 4 modified with ZrO 2 for hydrogen generation from solar thermochemical water-splitting reaction. MRS Online Proceedings Library Archive:1387

Blanco-Andujar C, Walter A et al (2016) Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia. Nanomedicine 11(14):1889–1910CrossRef

Bomati-Miguel O, Miguel-Sancho N et al (2014) Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects. J Nanopart Res 16(3):1–13CrossRef

Bomatí-Miguel O, Morales MP et al (2005) Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging. Biomaterials 26(28):5695–5703CrossRef

Bondarenko O, Juganson K et al (2013) Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review. Arch Toxicol 87(7):1181–1200CrossRef

Brahma P, Banerjee S et al (2002) Properties of nanocomposites of α-Fe and Fe 3 O 4. J Magn Magn Mater 246(1):162–168CrossRef

Brooks RA, Moiny F et al (2001) On T2-shortening by weakly magnetized particles: the chemical exchange model. Magn Reson Med 45(6):1014–1020CrossRef

Brunner TJ, Wick P et al (2006) vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 40(14):4374–4381

Bucci OM, Crocco L et al (2015) On the optimal measurement configuration for magnetic nanoparticles-enhanced breast cancer microwave imaging. IEEE Trans Biomed Eng 62(2):407–414CrossRef

Budde MD, Frank JA (2009) Magnetic tagging of therapeutic cells for MRI. J Nucl Med 50(2):171–174CrossRef

Bulte JW, Kraitchman DL (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17(7):484–499CrossRef

Cedervall T, Lynch I et al (2007) Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc Natl Acad Sci 104(7):2050–2055CrossRef

Chamundeeswari M, Sastry T et al (2013) Iron nanoparticles from animal blood for cellular imaging and targeted delivery for cancer treatment. Biochim Biophys Acta Gen Subj 1830(4):3005–3010CrossRef

Chatterjee S, Sarkar K (2013) A computational and mathematical approach towards the design and synthesis of uniform Au seed decorated Fe 3 O 4 nanoparticle for potential bio-application. Procedia Technol 10:457–463CrossRef

Chen D-H, He X-R (2001) Synthesis of nickel ferrite nanoparticles by sol-gel method. Mater Res Bull 36(7):1369–1377CrossRef

Chen F, Gerion D (2004) Fluorescent CdSe/ZnS nanocrystal–peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett 4(10):1827–1832CrossRef

Chen G, Chen W et al (2009) MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression. Biomaterials 30(10):1962–1970CrossRef

Chen H, Sulejmanovic D et al (2014) Iron-loaded magnetic nanocapsules for pH-triggered drug release and MRI imaging. Chem Mater 26(6):2105–2112CrossRef

Chen R, Ling D et al (2015) Parallel comparative studies on mouse toxicity of oxide nanoparticle-and gadolinium-based T1 MRI contrast agents. ACS Nano 9(12):12425–12435

Chen X, Gambhir SS et al (2011) Theranostic nanomedicine. Acc Chem Res 44(10):841–841CrossRef

Cheng C, Xu F et al (2011) Facile synthesis and morphology evolution of magnetic iron oxide nanoparticles in different polyol processes. New J Chem 35(5):1072–1079CrossRef

Cheong S, Ferguson P et al (2011) Simple synthesis and functionalization of iron nanoparticles for magnetic resonance imaging. Angew Chem Int Ed 50(18):4206–4209

Chin AB, Yaacob II (2007) Synthesis and characterization of magnetic iron oxide nanoparticles via w/o microemulsion and Massart's procedure. J Mater Process Technol 191(1):235–237CrossRef

Clapsaddle BJ, Gash AE et al (2003) Silicon oxide in an iron (III) oxide matrix: the sol–gel synthesis and characterization of Fe–Si mixed oxide nanocomposites that contain iron oxide as the major phase. J Non-Cryst Solids 331(1):190–201CrossRef

Clarkson R (2002) Blood-pool MRI contrast agents: properties and characterization. Springer, Contrast Agents I, pp 201–235

Colvin, V. (2003). The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21:1166–1170. Find this article online.

Couture P, Williams G et al (2017) Nanocrystalline multiferroic BiFeO 3 thin films made by room temperature sputtering and thermal annealing, and formation of an iron oxide-induced exchange bias. J Alloys Compd 695:3061–3068CrossRef

Cui H, Liu Y et al (2013) Structure switch between α-Fe 2 O 3, γ-Fe 2 O 3 and Fe 3 O 4 during the large scale and low temperature sol–gel synthesis of nearly monodispersed iron oxide nanoparticles. Adv Powder Technol 24(1):93–97CrossRef

Cui X, Belo S et al (2014) Aluminium hydroxide stabilised MnFe 2 O 4 and Fe 3 O 4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging. Biomaterials 35(22):5840–5846CrossRef

Dalle-Donne I, Rossi R et al (2007) S-glutathionylation in protein redox regulation. Free Radic Biol Med 43(6):883–898CrossRef

David B, Pizúrová N et al (2004) Preparation of iron/graphite core–shell structured nanoparticles. J Alloys Compd 378(1):112–116CrossRef

De Montferrand C, Hu L et al (2013) Iron oxide nanoparticles with sizes, shapes and compositions resulting in different magnetization signatures as potential labels for multiparametric detection. Acta Biomater 9(4):6150–6157CrossRef

Di Carlo L, Conte DE et al (2014) Microwave-assisted fluorolytic sol–gel route to iron fluoride nanoparticles for Li-Ion batteries. Chem Commun 50(4):460–462CrossRef

Díaz B, Sánchez-Espinel C et al (2008) Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates. Small 4(11):2025–2034CrossRef

DiMarino AM, Caplan AI et al (2013) Mesenchymal stem cells in tissue repair. Front Immunol 4:201CrossRef

Ding Y, Hu Y et al (2004) Polymer–monomer pairs as a reaction system for the synthesis of magnetic Fe3O4–polymer hybrid hollow nanospheres. Angew Chem Int Ed 43(46):6369–6372CrossRef

Doan BT, Seguin J et al (2012) Functionalized single-walled carbon nanotubes containing traces of iron as new negative MRI contrast agents for in vivo imaging. Contrast Media Mol Imaging 7(2):153–159CrossRef

Dobrovolskaia MA, Patri AK et al (2009) Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles. Nanomed: Nanotechnol, Biol Med 5(2):106–117CrossRef

Dong Y, Wang H et al (2017) Electrical and hydrogen reduction enhances kinetics in doped zirconia and ceria: I. grain growth study. J Am Ceram Soc 100(3):876–886

Duan H, Kuang M et al (2008) Reexamining the effects of particle size and surface chemistry on the magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. J Phys Chem C 112(22):8127–8131CrossRef

Dürr S, Janko C et al (2013) Magnetic nanoparticles for cancer therapy. Nanotechnol Rev 2(4):395–409CrossRef

Duzgunes N, Düzgüneş N (2012) Nanomedicine: Infectious Diseases. Immunotherapy, Diagnostics, Antifibrotics, Toxicology and Gene Medicine, Elsevier

Eghbali P, Fattahi H et al (2016) Fluorophore-tagged superparamagnetic iron oxide nanoparticles as bimodal contrast agents for MR/optical imaging. J Iran Chem Soc 13(1):87–93

Fang C, Zhang M (2009) Multifunctional magnetic nanoparticles for medical imaging applications. J Mater Chem 19(35):6258–6266CrossRef

Ferguson RM, Khandhar AP et al (2015) Magnetic particle imaging with tailored iron oxide nanoparticle tracers. IEEE Trans Med Imaging 34(5):1077–1084CrossRef

Fornara A, Johansson P et al (2008) Tailored magnetic nanoparticles for direct and sensitive detection of biomolecules in biological samples. Nano Lett 8(10):3423–3428CrossRef

Freire T, Dutra L et al (2016) Fast ultrasound assisted synthesis of CHITOSAN-based magnetite NANOCOMPOSITES as a modified electrode sensor. In: Carbohydrate Polymers

Frey NA, Peng S et al (2009) Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem Soc Rev 38(9):2532–2542CrossRef

Gautam A, van Veggel FC (2013) Synthesis of nanoparticles, their biocompatibility, and toxicity behavior for biomedical applications. J Mater Chem B 1(39):5186–5200CrossRef

Gessner A, Lieske A et al (2002) Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis. Eur J Pharm Biopharm 54(2):165–170CrossRef

Gessner A, Lieske A et al (2003) Functional groups on polystyrene model nanoparticles: influence on protein adsorption. J Biomed Mater Res A 65(3):319–326CrossRef

Glasgow W, Fellows B et al (2016) Continuous synthesis of iron oxide (Fe 3 O 4) nanoparticles via thermal decomposition. Particuology 26:47–53CrossRef

Gogola D, Štrbák O et al (2013) Contrast agents based on magnetic nanoparticles and its interaction with surrounding environment during contrast imaging. MEASUREMENT:299–302

Grabinski CM, Salaklang J et al (2014) Multifunctionalized spions for nuclear targeting: cell uptake and gene expression. Nano 9(01):1450009CrossRef

Gref R, Lück M et al (2000) ‘Stealth’corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B Biointerfaces 18(3):301–313CrossRef

Guardia P, Batlle-Brugal B et al (2007) Surfactant effects in magnetite nanoparticles of controlled size. J Magn Magn Mater 316(2):e756–e759CrossRef

Gupta AK, Curtis AS (2004) Surface modified superparamagnetic nanoparticles for drug delivery: interaction studies with human fibroblasts in culture. J Mater Sci Mater Med 15(4):493–496CrossRef

Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26(18):3995–4021CrossRef

Gupta AK, Wells S (2004) Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies. IEEE Trans Nanobioscience 3(1):66–73CrossRef

Gutiérrez L, Costo R et al (2015) Synthesis methods to prepare single-and multi-core iron oxide nanoparticles for biomedical applications. Dalton Trans 44(7):2943–2952CrossRef

Hachani R, Lowdell M et al (2016a) Correction: polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale 8(7):4395CrossRef

Hachani R, Lowdell M et al (2016b) Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale 8(6):3278–3287CrossRef

Hadjipanayis CG, Bonder MJ et al (2008) Metallic iron nanoparticles for MRI contrast enhancement and local hyperthermia. Small 4(11):1925–1929CrossRef

Hajba L, Guttman A (2016) The use of magnetic nanoparticles in cancer theranostics: toward handheld diagnostic devices. Biotechnol Adv 34(4):354–361CrossRef

Halliwell B, Gutteridge JM (2015) Free radicals in biology and medicine. Oxford University Press, USACrossRef

Hao R, Xing R et al (2010) Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles. Adv Mater 22(25):2729–2742CrossRef

Harisinghani MG, Barentsz J et al (2003) Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 348(25):2491–2499CrossRef

Haynes CL, Hurley KR et al (2016) Mesoporous silica-coated nanoparticles. US Patent 20,160 051:471

Hoshino A, Fujioka K et al (2004) Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4(11):2163–2169CrossRef

Huang H, Zhang X-F et al (2013) Manipulated electromagnetic losses by integrating chemically heterogeneous components in Fe-based core/shell architecture. J Appl Phys 113(8):084312CrossRef

Huang J, Zhong X et al (2012) Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. Theranostics 2(1):86CrossRef

Hufschmid R, Arami H et al (2015) Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition. Nanoscale 7(25):11142–11154CrossRef

Huh Y-M, Jun Y-w et al (2005) In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc 127(35):12387–12391CrossRef

Hurley KR, Ring HL et al (2016) Predictable heating and positive MRI contrast from a mesoporous silica-coated iron oxide nanoparticle. In: Molecular pharmaceutics

Hyeon T, Lee SS et al (2001) Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J Am Chem Soc 123(51):12798–12801CrossRef

Iqbal MZ, Ma X et al (2015) Silica-coated super-paramagnetic iron oxide nanoparticles (SPIONPs): a new type contrast agent of T 1 magnetic resonance imaging (MRI). J Mater Chem B 3(26):5172–5181CrossRef

Jae-Hyun L, Yong-Min H et al (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13(1):95CrossRef

Jagadale TC, Takale SP et al (2008) N-doped TiO2 nanoparticle based visible light photocatalyst by modified peroxide sol–gel method. J Phys Chem C 112(37):14595–14602CrossRef

Jain S, Rathi VV et al (2012) Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin. Nanomedicine 7(9):1311–1337CrossRef

Jana NR, Chen Y et al (2004) Size-and shape-controlled magnetic (Cr, Mn, Fe, Co, Ni) oxide nanocrystals via a simple and general approach. Chem Mater 16(20):3931–3935CrossRef

Jang J t, Nah H et al (2009) Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles. Angew Chem 121(7):1260–1264CrossRef

Jennings LE, Long NJ (2009) ‘Two is better than one’—probes for dual-modality molecular imaging. Chem Commun (24):3511–3524

Jing, X.-h., L. Yang, et al. (2008). In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection. Joint Bone Spine 75(4): 432-438.

Jitianu A, Raileanu M et al (2006) Fe3O4–SiO2 nanocomposites obtained via alkoxide and colloidal route. J Sol-Gel Sci Technol 40(2-3):317–323CrossRef

Joshi HM, Lin YP et al (2009) Effects of shape and size of cobalt ferrite nanostructures on their MRI contrast and thermal activation. J Phys Chem C 113(41):17761–17767CrossRef

Jun Y w, Lee JH et al (2008a) Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew Chem Int Ed 47(28):5122–5135CrossRef

Jun YW, Seo JW et al (2008b) Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. Acc Chem Res 41(2):179–189

Kahn E, Tessier C et al (2002) Distribution of injected MRI contrast agents in mouse livers studied by confocal and SIMS microscopy. Anal Quant Cytol Histol 24(5):295–302

Kamaly N, Miller AD (2010) Paramagnetic liposome nanoparticles for cellular and tumour imaging. Int J Mol Sci 11(4):1759–1776CrossRef

Kandpal ND, Sah N et al (2014) Co-precipitation method of synthesis and characterization of iron oxide nanoparticles. J Sci Ind Res 73:87–90

Kasche V, de Boer M et al (2003) Direct observation of intraparticle equilibration and the rate-limiting step in adsorption of proteins in chromatographic adsorbents with confocal laser scanning microscopy. J Chromatogr B 790(1):115–129CrossRef

Kato T, Yashiro T et al (2003) Evidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillaries. Cell Tissue Res 311(1):47–51CrossRef

Kim BH, Lee N et al (2011) Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T 1 magnetic resonance imaging contrast agents. J Am Chem Soc 133(32):12624–12631CrossRef

Kim D, Lee N et al (2008) Synthesis of uniform ferrimagnetic magnetite nanocubes. J Am Chem Soc 131(2):454–455CrossRef

Kim J, Kim HS et al (2008) Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew Chem Int Ed 47(44):8438–8441CrossRef

Kim J, Piao Y et al (2009) Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chem Soc Rev 38(2):372–390CrossRef

Kim SJ, Lewis B et al (2016) Superparamagnetic iron oxide nanoparticles for direct labeling of stem cells and in vivo MRI tracking. Contrast Media Mol Imaging 11(1):55–64CrossRef

Kim YB, Bae KH et al (2009) Positive contrast visualization for cellular magnetic resonance imaging using susceptibility-weighted echo-time encoding. Magn Reson Imaging 27(5):601–610CrossRef

Kircher MF, Gambhir SS et al (2011) Noninvasive cell-tracking methods. Nat Rev Clin Oncol 8(11):677–688CrossRef

Kirchner C, Liedl T et al (2005) Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 5(2):331–338CrossRef

Kluchova K, Zboril R et al (2009) Superparamagnetic maghemite nanoparticles from solid-state synthesis—their functionalization towards peroral MRI contrast agent and magnetic carrier for trypsin immobilization. Biomaterials 30(15):2855–2863CrossRef

Kolesnichenko, V., G. Goloverda, et al. (2016). Iron oxide nanoparticles with a variable size and an iron oxidation state for imaging applications.

Kucheryavy P, He J et al (2013) Superparamagnetic iron oxide nanoparticles with variable size and an iron oxidation state as prospective imaging agents. Langmuir 29(2):710–716CrossRef

Kuo Y-T, Chen C-Y et al (2016) Development of bifunctional gadolinium-labeled superparamagnetic nanoparticles (Gd-MnMEIO) for in vivo MR imaging of the liver in an animal model. PloS One 11(2):e0148695

Labarre D, Vauthier C et al (2005) Interactions of blood proteins with poly (isobutylcyanoacrylate) nanoparticles decorated with a polysaccharidic brush. Biomaterials 26(24):5075–5084CrossRef

Lacroix L-M, Frey Huls N et al (2011) Stable single-crystalline body centered cubic Fe nanoparticles. Nano Lett 11(4):1641–1645CrossRef

Lartigue L n, Hugounenq P et al (2012) Cooperative organization in iron oxide multi-core nanoparticles potentiates their efficiency as heating mediators and MRI contrast agents. ACS Nano 6(12):10935–10949

Laurent S, Bridot J-L et al (2010) Magnetic iron oxide nanoparticles for biomedical applications. Future 2(3):427–449

Laurent S, Forge D et al (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108(6):2064–2110CrossRef

Lawaczeck R, Menzel M et al (2004) Superparamagnetic iron oxide particles: contrast media for magnetic resonance imaging. Appl Organomet Chem 18(10):506–513CrossRef

Lawrence MJ, Rees GD (2000) Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 45(1):89–121CrossRef

Leao Andrade A, Domingos Fabris J et al (2015) Current status of magnetite-based Core@Shell structures for diagnosis and therapy in oncology short running title: biomedical applications of magnetite@shell structures. Curr Pharm Des 21(37):5417–5433CrossRef

Lee J-H, Huh Y-M et al (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13(1):95–99CrossRef

Lee N, Choi Y et al (2012) Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors. Nano Lett 12(6):3127–3131CrossRef

Lee N, Hyeon T (2012) Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents. Chem Soc Rev 41(7):2575–2589CrossRef

Lee N, Kim H et al (2011) Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets. Proc Natl Acad Sci 108(7):2662–2667CrossRef

Leonardi S, Mirzaei A et al (2016) A comparison of the ethanol sensing properties of α-iron oxide nanostructures prepared via the sol–gel and electrospinning techniques. Nanotechnology 27(7):075502CrossRef

Li L, Jiang W et al (2013) Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking. Theranostics 3(8):595–615CrossRef

Li N, Xia T et al (2008) The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44(9):1689–1699CrossRef

Li YF, Chen C (2011) Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small 7(21):2965–2980CrossRef

Li Z, Tan B et al (2008) Direct coprecipitation route to monodisperse dual-functionalized magnetic iron oxide nanocrystals without size selection. Small 4(2):231–239CrossRef

Lindman S, Lynch I et al (2007) Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity. Nano Lett 7(4):914–920CrossRef

Ling D, Hyeon T (2013) Chemical design of biocompatible iron oxide nanoparticles for medical applications. Small 9(9-10):1450–1466CrossRef

Ling D, Lee N et al (2015) Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. Acc Chem Res 48(5):1276–1285CrossRef

Liu G, Gao J et al (2013) Applications and potential toxicity of magnetic iron oxide nanoparticles. Small 9(9-10):1533–1545CrossRef

Liu G, Xie J et al (2011) N-alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery. Small 7(19):2742–2749CrossRef

Liu H, Chi D (2016) Synthesis of iron sulfide and iron oxide nanocrystal thin films for green energy applications. Procedia Eng 141:32–37

Liu W, Ma J et al (2016) Micron-size superparamagnetic iron-oxides watercress with unique MRI properties. Mater Chem Phys 170:123–128

Long GJ, Grandjean F (2013) Mössbauer spectroscopy applied to inorganic chemistry. Media, Springer Science & Business

Lynch I (2007) Are there generic mechanisms governing interactions between nanoparticles and cells? Epitope mapping the outer layer of the protein–material interface. Physica A: Statistical Mechanics and its Applications 373:511–520CrossRef

Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. Nano Today 3(1):40–47

Magnitsky S, Zhang J et al (2017) Positive contrast from cells labeled with iron oxide nanoparticles: quantitation of imaging data. Magn Reson Med 78(5):1900–1910

Mailänder V, Lorenz MR et al (2008) Carboxylated superparamagnetic iron oxide particles label cells intracellularly without transfection agents. Mol Imaging Biol 10(3):138–146CrossRef

Mao B, Kang Z et al (2006) Synthesis of magnetite octahedrons from iron powders through a mild hydrothermal method. Mater Res Bull 41(12):2226–2231CrossRef

Markides H, Rotherham M et al (2012) Biocompatibility and toxicity of magnetic nanoparticles in regenerative medicine. J Nanomater 2012:13CrossRef

Masthoff I-C, Kraken M et al (2016) Study of the growth of hydrophilic iron oxide nanoparticles obtained via the non-aqueous sol–gel method. J Sol-Gel Sci Technol 77(3):553–564CrossRef

Matijevic E, Borkovec M (2012) Surface and colloid science. Springer US.

Mazuel F, Espinosa A et al (2016) Massive intracellular biodegradation of iron oxide nanoparticles evidenced magnetically at single-endosome and tissue levels. ACS Nano 10(8):7627–7638

McDonagh BH, Singh G et al (2016) L-dopa-coated manganese oxide nanoparticles as dual MRI contrast agents and drug-delivery vehicles. Small 12(3):301–306CrossRef

Møller P, Jacobsen NR et al (2010) Role of oxidative damage in toxicity of particulates. Free Radic Res 44(1):1–46

Monopoli MP, Walczyk D et al (2011) Physical–chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc 133(8):2525–2534CrossRef

Monteiro-Riviere N, Inman A et al (2009) Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line. Toxicol Appl Pharmacol 234(2):222–235CrossRef

Mooney DJ, Vandenburgh H (2008) Cell delivery mechanisms for tissue repair. Cell Stem Cell 2(3):205–213

Morris MC, Gros E et al (2007) A non-covalent peptide-based carrier for in vivo delivery of DNA mimics. Nucleic Acids Res 35(7):e49CrossRef

Mou X, Ali Z et al (2015) Applications of magnetic nanoparticles in targeted drug delivery system. J Nanosci Nanotechnol 15(1):54–62CrossRef

Mulder WJ, Griffioen AW et al (2007) Magnetic and fluorescent nanoparticles for multimodality imaging. Nanomedicine 2(3):307–324CrossRef

Mulens, V., M. d. P. Morales, et al. (2013). Development of magnetic nanoparticles for cancer gene therapy: a comprehensive review. ISRN Nanomaterials 2013.

Na HB, Song IC et al (2009) Inorganic nanoparticles for MRI contrast agents. Adv Mater 21(21):2133–2148CrossRef

Nachimuthu RK, Jeffery RD et al (2014) Investigation of cerium-substituted europium iron garnets deposited by biased target ion beam deposition. IEEE Trans Magn 50(12):1–7CrossRef

Nagineni VS, Zhao S et al (2005) Microreactors for syngas conversion to higher alkanes: characterization of sol–gel-encapsulated nanoscale Fe–Co catalysts in the microchannels. Ind Eng Chem Res 44(15):5602–5607CrossRef

Neamnark A, Suwantong O et al (2009) Aliphatic lipid substitution on 2 kDa polyethylenimine improves plasmid delivery and transgene expression. Mol Pharm 6(6):1798–1815CrossRef

Nel A, Xia T et al (2006) Toxic potential of materials at the nanolevel. Science 311(5761):622–627CrossRef

Nie Z, Petukhova A et al (2010) Properties and emerging applications of self-assembled structures made from inorganic nanoparticles. Nat Nanotechnol 5(1):15–25CrossRef

Nitin N, LaConte L et al (2004) Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent. JBIC. J Biol Inorg Chem 9(6):706–712CrossRef

Nizameev, I., A. Mustafina, et al. (2017). High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1, 3-diketones.

Nyström AM, Fadeel B (2012) Safety assessment of nanomaterials: implications for nanomedicine. J Control Release 161(2):403–408CrossRef

Oberdörster E (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 112(10):1058CrossRef

Oberdörster G, Oberdörster E et al (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823CrossRef

Otsuka H, Nagasaki Y et al (2003) PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Deliv Rev 55(3):403–419CrossRef

Padmanabhan P, Kumar A et al (2016) Nanoparticles in practice for molecular-imaging applications: an overview. In: Acta biomaterialia

Palekar RU, Jallouk AP et al (2015) Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents. Nanomedicine 10(11):1817–1832CrossRef

Park J, Lee E et al (2005) One-nanometer-scale size-controlled synthesis of monodisperse magnetic Iron oxide nanoparticles. Angew Chem 117(19):2932–2937CrossRef

Patel S, Hota G (2016) Iron oxide nanoparticle-immobilized PAN nanofibers: synthesis and adsorption studies. RSC Adv 6(19):15402–15414CrossRef

Pereira C, Pereira AM et al (2012) Superparamagnetic MFe2O4 (M= Fe, Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a novel one-step coprecipitation route. Chem Mater 24(8):1496–1504CrossRef

Petersen EJ, Nelson BC (2010) Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA. Anal Bioanal Chem 398(2):613–650CrossRef

Piao Y, Burns A et al (2008) Designed fabrication of silica-based nanostructured particle systems for nanomedicine applications. Adv Funct Mater 18(23):3745–3758CrossRef

Pisanic TR, Blackwell JD et al (2007) Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials 28(16):2572–2581CrossRef

Poller WC, Ramberger E et al (2016) Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells. Nano Res 9(11):3437–3452CrossRef

Primc D, Belec B et al (2016) Synthesis of composite nanoparticles using co-precipitation of a magnetic iron-oxide shell onto core nanoparticles. J Nanopart Res 18(3):1–13CrossRef

Rabias I, Fardis M et al (2008) No aging phenomena in ferrofluids: the influence of coating on interparticle interactions of maghemite nanoparticles. ACS Nano 2(5):977–983

Rabias I, Fardis M et al (2015) Novel synthesis of ultra-small dextran coated maghemite nanoparticles for MRI and CT contrast agents via a low temperature co-precipitation reaction. J Nanosci Nanotechnol 15(1):205–210CrossRef

Ramniceanu G, Doan B-T et al (2016) Delayed hepatic uptake of multi-phosphonic acid poly (ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging. RSC Adv 6(68):63788–63800CrossRef

Reddy LH, Arias JL et al (2012) Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev 112(11):5818–5878CrossRef

Remya N, Syama S et al (2016) Toxicity, toxicokinetics and biodistribution of dextran stabilized iron oxide nanoparticles for biomedical applications. Int J Pharm 511(1):586–598CrossRef

Riaz S, Ashraf R et al (2014) Microwave assisted iron oxide nanoparticles—structural and magnetic properties. IEEE Trans Magn 50(8):1–4

Richard S, Eder V et al (2016) USPIO size control through microwave nonaqueous sol-gel method for neoangiogenesis T2 MRI contrast agent. Nanomedicine 11(21):2769–2779

Rivera Gil P, Oberdörster G n et al (2010) Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future. Acs Nano 4(10):5527–5531CrossRef

Roca A, Morales M et al (2006) Structural and magnetic properties of uniform magnetite nanoparticles prepared by high temperature decomposition of organic precursors. Nanotechnology 17(11):2783CrossRef

Roca AG, Marco JF et al (2007) Effect of nature and particle size on properties of uniform magnetite and maghemite nanoparticles. J Phys Chem C 111(50):18577–18584CrossRef

Rozanova N, Zhang JZ (2013) Metal and magnetic nanostructures for cancer diagnosis and therapy. Reviews in. Nanosci Nanotechnol 2(1):29–41CrossRef

Rubio-Navarro A, Carril M et al (2016) CD163-macrophages are involved in rhabdomyolysis-induced kidney injury and may be detected by MRI with targeted gold-coated iron oxide nanoparticles. Theranostics 6(6):896CrossRef

Saeidian H, Moghaddam FM et al (2009) Superabsorbent polymer as nanoreactors for preparation of hematite nanoparticles and application of the prepared nanocatalyst for the Friedel-Crafts acylation. J Braz Chem Soc 20(3):466–471CrossRef

Safontseva NY, Nikiforov IY (2001) On the shape of iron K absorption edges for monoferrites with a Me (Mg, Mn, Ni, Zn) Fe 2 O 4 spinel structure. Phys Solid State 43(1):61–64CrossRef

Salvador-Morales C, Flahaut E et al (2006) Complement activation and protein adsorption by carbon nanotubes. Mol Immunol 43(3):193–201CrossRef

Santra S, Tapec R et al (2001) Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion: the effect of nonionic surfactants. Langmuir 17(10):2900–2906CrossRef

Sathya A, Guardia P et al (2016) Co x Fe3–x O4 nanocubes for theranostic applications: effect of cobalt content and particle size. Chem Mater 28(6):1769–1780CrossRef

Sayes CM, Gobin AM et al (2005) Nano-C 60 cytotoxicity is due to lipid peroxidation. Biomaterials 26(36):7587–7595CrossRef

Schäfer R, Kehlbach R et al (2007) Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide. Radiology 244(2):514–523CrossRef

Shabestari Khiabani S, Farshbaf M et al (2016) Magnetic nanoparticles: preparation methods, applications in cancer diagnosis and cancer therapy. Artif Cells Nanomed Biotechnol 45(1):6–17

Sharifi S, Behzadi S et al (2012) Toxicity of nanomaterials. Chem Soc Rev 41(6):2323–2343CrossRef

Sheng-Nan S, Chao W et al (2014) Magnetic iron oxide nanoparticles: synthesis and surface coating techniques for biomedical applications. Chin Phys B 23(3):037503CrossRef

Shin J, Anisur RM et al (2009) Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery. Angew Chem Int Ed 48(2):321–324CrossRef

Shin T-H, Choi Y et al (2015) Recent advances in magnetic nanoparticle-based multi-modal imaging. Chem Soc Rev 44(14):4501–4516CrossRef

Simberg D, Park J-H et al (2009) Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials 30(23):3926–3933CrossRef

Simeonidis K, Mourdikoudis S et al (2007) Controlled synthesis and phase characterization of Fe-based nanoparticles obtained by thermal decomposition. J Magn Magn Mater 316(2):e1–e4CrossRef

Smolensky ED, Park H-YE et al (2013) Scaling laws at the nanosize: the effect of particle size and shape on the magnetism and relaxivity of iron oxide nanoparticle contrast agents. J Mater Chem B 1(22):2818–2828CrossRef

Soenen SJ, Brisson AR et al (2009) Addressing the problem of cationic lipid-mediated toxicity: the magnetoliposome model. Biomaterials 30(22):3691–3701CrossRef

Soenen SJ, De Cuyper M (2009) Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes. Contrast Media Mol Imaging 4(5):207–219CrossRef

Soenen SJ, Himmelreich U et al (2011) Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials 32(1):195–205CrossRef

Soenen SJ, Illyes E et al (2009) The role of nanoparticle concentration-dependent induction of cellular stress in the internalization of non-toxic cationic magnetoliposomes. Biomaterials 30(36):6803–6813CrossRef

Sohn O-J, Kim C-K et al (2008) Immobilization of glucose oxidase and lactate dehydrogenase onto magnetic nanoparticles for bioprocess monitoring system. Biotechnol Bioprocess Eng 13(6):716–723CrossRef

Sood A, Arora V et al (2016) Ascorbic acid-mediated synthesis and characterisation of iron oxide/gold core–shell nanoparticles. J Exp Nanosci 11(5):370–382CrossRef

Sood A, Arora V et al (2017) Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications. Mater Sci Eng C 80:274–281CrossRef

Souto EB, Müller RH (2010) Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes. Springer, Drug delivery, pp 115–141

Stephen ZR, Kievit FM et al (2011) Magnetite nanoparticles for medical MR imaging. Mater Today 14(7):330–338CrossRef

Sun DH, Trindade MC et al (2003) Human serum opsonization of orthopedic biomaterial particles: protein-binding and monocyte/macrophage activation in vitro. J Biomed Mater Res A 65(2):290–298CrossRef

Sun S, Zeng H (2002) Size-controlled synthesis of magnetite nanoparticles. J Am Chem Soc 124(28):8204–8205CrossRef

Sun S, Zeng H et al (2004) Monodisperse mfe2o4 (m= fe, co, mn) nanoparticles. J Am Chem Soc 126(1):273–279CrossRef

Szpak A, Fiejdasz S et al (2014) T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes. J Nanopart Res 16(11):1–11CrossRef

Takami S, Sato T et al (2007) Hydrothermal synthesis of surface-modified iron oxide nanoparticles. Mater Lett 61(26):4769–4772CrossRef

Tang Y, Chen Q (2007) A simple and practical method for the preparation of magnetite nanowires. Chem Lett 36(7):840–841CrossRef

Tarin C, Carril M et al (2015) Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI. Scientific reports 5

Tartaj P, González-Carreño T et al (2004) From hollow to dense spheres: control of dipolar interactions by tailoring the architecture in colloidal aggregates of superparamagnetic iron oxide nanocrystals. Adv Mater 16(6):529–533CrossRef

Tartaj P, Serna CJ (2002) Microemulsion-assisted synthesis of tunable superparamagnetic composites. Chem Mater 14(10):4396–4402CrossRef

Tassa C, Shaw SY et al (2011) Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy. Acc Chem Res 44(10):842–852CrossRef

Tavakoli A, Sohrabi M et al (2007) A review of methods for synthesis of nanostructured metals with emphasis on iron compounds. Chem Pap 61(3):151–170CrossRef

Tenzer S, Docter D et al (2013) Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nat Nanotechnol 8(10):772–781CrossRef

Thomas R, Park I-K et al (2013) Magnetic iron oxide nanoparticles for multimodal imaging and therapy of cancer. Int J Mol Sci 14(8):15910–15930CrossRef

Thorek DL, Chen AK et al (2006) Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng 34(1):23–38CrossRef

Thu MS, Bryant LH et al (2012) Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging. Nat Med 18(3):463–467CrossRef

Tombácz E, Turcu R et al (2015) Magnetic iron oxide nanoparticles: recent trends in design and synthesis of magnetoresponsive nanosystems. Biochem Biophys Res Commun 468(3):442–453CrossRef

Tong S, Hou S et al (2010) Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. Nano Lett 10(11):4607–4613CrossRef

Trewyn BG, Slowing II et al (2007) Synthesis and functionalization of a mesoporous silica nanoparticle based on the sol–gel process and applications in controlled release. Acc Chem Res 40(9):846–853CrossRef

Tromsdorf UI, Bruns OT et al (2009) A highly effective, nontoxic T 1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles. Nano Lett 9(12):4434–4440CrossRef

Umair M, Javed I et al (2016) Nanotoxicity of inert materials: the case of gold, silver and iron. J Pharm Pharm Sci 19(2):161–180CrossRef

Unfried K, Albrecht C et al (2007) Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1(1):52–71CrossRef

van Schooneveld MM, Vucic E et al (2008) Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation. Nano Lett 8(8):2517–2525CrossRef

Walkey CD, Chan WC (2012) Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment. Chem Soc Rev 41(7):2780–2799CrossRef

Wang W, Pacheco V et al (2012a) Size and compositional effects on contrast efficiency of functionalized superparamagnetic nanoparticles at ultralow and ultrahigh magnetic fields. J Phys Chem C 116(33):17880–17884CrossRef

Wang H, Shrestha TB et al (2012b) Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages. Beilstein J Nanotechnol 3:444CrossRef

Wang L, Tang W et al (2014) Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T 2 suppression. Magn Reson Imaging 32(6):671–678CrossRef

Wang Q, Shen M et al (2015) Low toxicity and long circulation time of polyampholyte-coated magnetic nanoparticles for blood pool contrast agents. Sci Rep 5:7774

Wang Y-XJ, Hussain SM et al (2001) Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol 11(11):2319–2331CrossRef

Wang, Y., C. Xu, et al. (2013). Commercial nanoparticles for stem cell labeling and.

Warheit DB, Laurence BR et al (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77(1):117–125CrossRef

Wei W, Quanguo H et al (2007) Preparation and characterization of magnetite Fe3O4 nanopowders. Rare Metal Mater Eng 36:238–243

Weissleder R, Lee H (2017) et al. Magnetic nanoparticles, Google Patents

Wetterskog E, Agthe M et al (2016) Precise control over shape and size of iron oxide nanocrystals suitable for assembly into ordered particle arrays. In: Science and Technology of Advanced Materials

William WY, Chang E et al (2006) Aqueous dispersion of monodisperse magnetic iron oxide nanocrystals through phase transfer. Nanotechnology 17(17):4483CrossRef

Woo K, Hong J et al (2004) Easy synthesis and magnetic properties of iron oxide nanoparticles. Chem Mater 16(14):2814–2818CrossRef

Wu J, Ding T et al (2013) Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus. Neurotoxicology 34:243–253CrossRef

Wu S, Sun A et al (2011) Fe 3 O 4 magnetic nanoparticles synthesis from tailings by ultrasonic chemical co-precipitation. Mater Lett 65(12):1882–1884CrossRef

Wu W, Wu Z et al (2015a) Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater 16(2):023501CrossRef

Wu M, Zhang D et al (2015b) Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy. Nanotechnology 26(11):115102CrossRef

Xia T, Kovochich M et al (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794–1807CrossRef

Xu C, Sun S (2013) New forms of superparamagnetic nanoparticles for biomedical applications. Adv Drug Deliv Rev 65(5):732–743CrossRef

Xu C, Teja AS (2008) Continuous hydrothermal synthesis of iron oxide and PVA-protected iron oxide nanoparticles. J Supercrit Fluids 44(1):85–91CrossRef

Xu J, Yang H et al (2007) Preparation and magnetic properties of magnetite nanoparticles by sol–gel method. J Magn Magn Mater 309(2):307–311CrossRef

Yalcin S, Khodadust R et al (2015) Synthesis and characterization of polyhydroxybutyrate coated magnetic nanoparticles: toxicity analyses on different cell lines. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal. Chemistry 45(5):700–708

Yang H, Zhuang Y et al (2011) Targeted dual-contrast T1- and T 2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles. Biomaterials 32(20):4584–4593CrossRef

Yang M, Gao L et al (2015a) Characterization of Fe 3 O 4/SiO 2/Gd 2 O (CO 3) 2 core/shell/shell nanoparticles as T1 and T2 dual mode MRI contrast agent. Talanta 131:661–665CrossRef

Yang L, Zhou Z et al (2015b) Europium-engineered iron oxide nanocubes with high T1 and T2 contrast abilities for MRI in living subjects. Nanoscale 7(15):6843–6850CrossRef

Yang X, Gondikas AP et al (2011) Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans. Environ Sci Technol 46(2):1119–1127CrossRef

Yazdani F, Fattahi B et al (2016) Synthesis of functionalized magnetite nanoparticles to use as liver targeting MRI contrast agent. J Magn Magn Mater 406:207–211CrossRef

Yen SK, Padmanabhan P et al (2013) Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery. Theranostics 3(12):986CrossRef

Yoon TJ, Lee H et al (2011) Highly magnetic core–shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed 50(20):4663–4666CrossRef

Yu L, Yang X et al (2011) Preparation and magnetic properties of doped Ni-Fe/Fe3O4 nanocomposite. Mater Manuf Process 26(11):1383–1387CrossRef

Zelina P, Jašek O et al (2012) Versatile low-pressure plasma-enhanced process for synthesis of iron and iron-based magnetic nanopowders. World Journal of. Engineering 9(2):161–166

Zeng D-W, Xiao R et al (2016) Liquid foam assisted sol–gel synthesis of iron oxides for hydrogen storage via chemical looping. Int J Hydrog Energy 41(32):13923–13933CrossRef

Zeng L, Ren W et al (2012) Ultrasmall water-soluble metal-iron oxide nanoparticles as T 1-weighted contrast agents for magnetic resonance imaging. Phys Chem Chem Phys 14(8):2631–2636CrossRef

Zhang H, Malik V et al (2017) Synthesis and characterization of Gd-doped magnetite nanoparticles. J Magn Magn Mater 423:386–394CrossRef

Zhang J, Ring HL et al (2016) Quantification and biodistribution of iron oxide nanoparticles in the primary clearance organs of mice using T1 contrast for heating. Magn Reson Med 78(2):702–712

Zhao X, Wang J et al (2010a) Removal of fluoride from aqueous media by Fe 3 O 4@ Al (OH) 3 magnetic nanoparticles. J Hazard Mater 173(1):102–109CrossRef

Zhao M-X, Xia Q et al (2010b) Synthesis, biocompatibility and cell labeling of L-arginine-functional β-cyclodextrin-modified quantum dot probes. Biomaterials 31(15):4401–4408CrossRef

Zhao Z, Zhou Z et al (2013) Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. Nat Commun 4:2266

Zhou Z, Wang L et al (2013) Engineered iron-oxide-based nanoparticles as enhanced T 1 contrast agents for efficient tumor imaging. ACS nano 7(4):3287–3296CrossRef

Zou J, Ostrovsky S et al (2016) Efficient penetration of ceric ammonium nitrate oxidant-stabilized gamma-maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI. In: Journal of Biomedical Materials Research Part B: Applied Biomaterials

Title: MRI based on iron oxide nanoparticles contrast agents: effect of oxidation state and architecture
Authors: Yasir Javed
Kanwal Akhtar
Hafeez Anwar
Yasir Jamil
Publication date: 01-11-2017
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2017
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4045-x

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