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01-10-2018 | Brief Communication

Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications

Authors: Antonio Palumbo Piccionello, Luca Menichetti, Paolo Armanetti, Alessandra Flori, Ilaria Monaco, Mirko Maturi, Andrea Pace, Erica Locatelli

Published in: Journal of Nanoparticle Research | Issue 10/2018

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Abstract

A selective functionalization of dopamine amino group with the photoluminescent 7-nitroben-zofurazan was achieved through a one-pot protection-functionalization-deprotection sequence. The resulting fluorescent catecholic ligand was used as a capping agent for iron oxide nanoparticles thus obtaining photoluminescent magnetic nanoparticles (PL-MNPs). The PL-MNPs were then embedded into PLGA-b-PEG polymeric nanocarriers which quenched the emission of the capping agent. Full recovery of fluorescence was observed after disassembling the polymeric layer of the nanoparticle, thus supporting the use of PL-MNPs as a multifunctional system for targeted drug delivery.

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Title: Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications
Authors: Antonio Palumbo Piccionello
Luca Menichetti
Paolo Armanetti
Alessandra Flori
Ilaria Monaco
Mirko Maturi
Andrea Pace
Erica Locatelli
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 10/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4365-5

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