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Journal of Materials Science
Published in: Journal of Materials Science 6/2019

04-12-2018 | Polymers

Polymer microsphere for water-soluble drug delivery via carbon dot-stabilizing W/O emulsion

Authors: Luyao Wang, Jianping Gao, Zhaolin An, Xiaoxiang Zhao, Hongduo Yao, Man Zhang, Qiang Tian, Xiangang Zhai, Yu Liu

Published in: Journal of Materials Science | Issue 6/2019

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Abstract

Emulsions, usually oil-in-water emulsions, have been widely applied to the preparation of hydrophobic drug carriers. However, the synthesis of safe, biocompatible and high-performance carriers for water-soluble drugs remains a challenge. So polyacrylamide (PAM) microspheres stabilized by carbon dots (CDs) were fabricated via a water-in-oil Pickering emulsion without the use of any surfactant. The PAM/CD microspheres were spherical with an even distribution of the CDs on their surfaces. The size of the microspheres can be controlled by changing the amount of CDs, which also influenced the drug loading properties. The hydrophilic chemotherapy drug, 5-fluorouracil (5-FU), was successfully loaded into the PAM/CD microspheres through incubation. The encapsulation efficiencies ranged from 68 to 82% with a maximum drug loading of 48%. The 5-FU release profiles depended on the concentration of the drug incubation solution, the concentration of the CD solution and the pH of the drug release environment. The release of 5-FU was relatively steady for the first 12 h and followed non-Fickian diffusion kinetics. This synthetic approach could be extrapolated to loading of other water-soluble drugs into hydrophilic polymers.
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Appendix
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Metadata
Title
Polymer microsphere for water-soluble drug delivery via carbon dot-stabilizing W/O emulsion
Authors
Luyao Wang
Jianping Gao
Zhaolin An
Xiaoxiang Zhao
Hongduo Yao
Man Zhang
Qiang Tian
Xiangang Zhai
Yu Liu
Publication date
04-12-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 6/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-03197-7

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