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Journal of Materials Science

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18.12.2017 | Biomaterials

Preparation and optimization of surface-engineered poly(lactic acid) microspheres as a drug delivery device

verfasst von: Z. A. Abdul Hamid, C. Y. Tham, Z. Ahmad

Erschienen in: Journal of Materials Science | Ausgabe 7/2018

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Abstract

One of the challenges in using poly(lactic acid) (PLA) as a drug delivery device is its lack of active functional groups and its hydrophobic nature. Therefore, a simple and feasible hydrolysis treatment using sodium hydroxide (NaOH) and hydrochloric acid (HCL) at different concentrations and treatment durations was utilized to modify the PLA microspheres’ surface hydrophobicity. In this research, we report the chemical and morphological changes of surface-engineered PLA microspheres/films with regard to its integrity as a drug delivery carrier. After the hydrolysis treatment, Fourier transform infrared spectroscopy results confirmed that there were chemical changes in the surface-engineered PLA microspheres as they changed from being hydrophobic to hydrophilic; additionally, an increase in –OH functional group was also detected. This change is also indicated by the increase in hydrophilicity of the bulk surface as illustrated by XPS analysis, contact angle, and zeta potential measurements. These results suggest that the hydrolysis treatment is a feasible way to change the surface properties of PLA microspheres to become more compatible with biological environment and to increase the amount of active functional sites. However, the bulk morphology changed from smooth to porous structure after 48 h and started to degrade after prolonged hydrolysis treatment. Thus, this work underlines the importance of controlling the hydrolysis treatment so as not to compromise the bulk morphology and integrity of PLA microspheres while enhancing its hydrophilicity.

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Anderson JM, Shive MS (2012) Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 64:72–82CrossRef

Freiberg S, Zhu X (2004) Polymer microspheres for controlled drug release. Int J Pharm 282:1–18CrossRef

Ulery BD, Nair LS, Laurencin CT (2011) Biomedical applications of biodegradable polymers. J Polym Sci B Polym Phys 49:832–864CrossRef

Kim J-H, Yoon J-Y (2002) Protein adsorption on polymer particles. In: Hubbard AT (ed) Encyclopedia of surface and colloid. Marcel Dekker, New York, pp 4373–4380

O’Donnell PB, McGinity JW (1997) Preparation of microspheres by solvent evaporation technique. Adv Drug Del Rev 28(1):25–42CrossRef

Wang S, Cui W, Bei J (2005) Bulk and surface modifications of polylactide. Anal Bioanal Chem 381:547–556CrossRef

Frietas S, Merkle HP, Gander B (2005) Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microspheres preparation process technology. J Control Release 102:313–332CrossRef

Wang X, Zhang L, Zhou G, Zhang G, Lu Y, Zhong Y (2010) Preparation of visualized iodized oil 5-fluorouracil loaded polylactic acid microspheres. Acad J Second Mil Med Univ 30:1100–1103CrossRef

Matsumoto A, Matsukawa Y, Suzuki T, Yoshino H, Kobayashi M (1997) The polymer-alloys method as a new preparation method of biodegradable microspheres: principle and application to cisplatin-loaded microspheres. J Control Release 48:19–27CrossRef

10.

Mason N, Thies C, Cicero TJ (1976) In vivo and in vitro evaluation of a microencapsulated narcotic antagonist. J Pharm Sci 65:847–850CrossRef

11.

Yolles S, Leafe TD, Woodland JH, Meyer FJ (1975) Long acting delivery systems for narcotic antagonists. 2. Release rates of naltrexone from poly(lactic acid) composites. J Pharm Sci 64:348–349CrossRef

12.

Lai M-K, Tsiang RC-C (2005) Micrencapsulation of acetaminophen into poly(L-lactide) by three different emulsion solvent-evaporation methods. J Microencapsul 22:261–274CrossRef

13.

Fargnoli AS, Mu A, Kats MG, Williams RD, Marguelies KB, Weiner DB, Yang S, Bridges CR (2014) Anti-inflammatory loaded poly-lactic acid nanoparticles formulations for enhance myocardial gene transfer: an in vitro assessment of a drug/gene combination therapeutic approach for direct injection. J Trans Med 12:171CrossRef

14.

Huang YY, Chung TW (2001) Microencapsulation of gentamicin in biodegradable PLA and/or PLA/PEG copolymer. J Microencapsul 18(4):457–465CrossRef

15.

Fan Y, Shan-Guang W, Yu-Fang P, Feng-Lan S, Tao L (2009) Preparation and characteristics of enthromycin microspheres for lung targeting. Drug Dev Ind Pharm 35:639–645CrossRef

16.

Mehta RC, Thanoo BC, DeLuca PP (1996) Peptide containing microspheres from low molecular weight and hydrophilic poly(d, l-lactide-co-glycolide). J Control Release 41:249–257CrossRef

17.

Herrmann J, Bodmeier R (1995) Effect of particle microstructureon the somatostatin release from poly(lactide) microspheres prepared by a W/O/W solvent evaporation method. J Control Release 36(1–2):63–71CrossRef

18.

Conway BR, Alpar HO (1996) Double emulsion microencapsulation of proteins as model antigens using polylactide polymers: effect of emulsifier on the microsphere characteristics and release kinetics. Eur J Pharm Biopharm 42:42–48

19.

Jeffery H, Davis SS, O’Hagan DT (1993) Preparation and characterization of poly(lactide-co-glycolide) microparticles Part 2. Entrapment of a model protein using a (water-in-oil in-water emulsion solvent evaporation technique. PharmRes 10:362–368

20.

Atala A (2009) Foundations of regenerative medicine: clinical and therapeutic applications, 1st edn. Academic Press, USA

21.

Jiao Y-P, Cui F-Z (2007) Surface modification of polyester biomaterials for tissue engineering. Biomed Mater 2:R24–R37CrossRef

22.

Fahmy TM, Samstein RM, Harness CC, Saltzman WM (2005) Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomatererials 26:5727–5736CrossRef

23.

Shin H, Jo S, Mikos AG (2003) Biomimetic materials for tissue engineering. Biomaterials 24:4353–4364CrossRef

24.

Vasitaa R, Shanmugama K, Kattia DS (2008) Improved biomaterials for tissue engineering applications: surface modification of polymers. Curr Top Med Chem 8:341–353CrossRef

25.

Bazile DV, Ropert C, Huve P, Verrecchia T, Marlard M, Frydman A et al (1991) Body distribution of fully biodegradable [¹⁴C]-poly(lactic acid) nanoparticles coated with albumin after parenteral administration to rats. Biomaterials 13(5):1093–1102

26.

Tsung MJ, Burgess DJ (2001) Preparation and characterization of gelatin surface modified PLGA microspheres. AAPS J 3(1):1–11CrossRef

27.

Gref R, Domb A, Quellec P, Blunk T, Müller RH, Verbavatz JM et al (2012) The controlled intravenous delivery of drug using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev 64:316–326CrossRef

28.

Stolnik S, Dunn SE, Garnett MC, Davies MC, Coombes AGA, Taylor DC et al (1994) Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharm Res 11(12):1800–1808CrossRef

29.

Redhead HM, Davis SS, Illum L (2001) Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 70:353–363CrossRef

30.

Müller M, Vörös J, Csucs G, Walter W, Danuser G, Merkle HP et al (2003) Surface modification of PLGA microspheres. J Biomed Mater Res A 66(1):55–61CrossRef

31.

Faraasen S, Vörös J, Csúcs G, Textor M, Merkle HP (2003) Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(l-lysine)-grafted poly(ethylene glycol) conjugate. Pharm Res 20(2):237–246CrossRef

32.

Kajdas C (2004) Hydrolysis. In: Totten GR, Liang H (eds) Surface modification and mechanisms. Friction, stress, and reaction engineering. New York: Marcel Dekker

33.

Nam YS, Yoon JJ, Lee JG, Park TG (1999) Adhesion behaviors of hepatocytes cultured onto biodegradable polymer surface modified by alkali hydrolysis process. J Biomater Sci 10(11):1145–1158CrossRef

34.

Gao J, Niklason L, Langer R (1998) Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells. J Biomed Mater Res 42(3):417–424CrossRef

35.

Yang J, Wan Y, Tu C, Cai Q, Bei J, Wang S (2003) Enhancing the cell affinity of macroporous poly(L-lactide) cell scaffold by a convenient surface modification method. Polym Int 52:1892–1899CrossRef

36.

Garric X, Molès J-P, Garreau H, Guilhou J-J, Vert M (2004) Human skin cell cultures onto PLA₅₀ (PDLLA) bioresorbable polymers: influence of chemical and morphological surface modifications. J Biomed Mater Res A 72(2):180–189

37.

Khang G, Choee J-H, Rhee JM, Lee HB (2002) Interaction of different types of cells on physicochemically treated poly(l-lactide-co-glycolide) surfaces. J Appl Polym Sci 85(6):1253–1262CrossRef

38.

Koo G-H, Jang J (2008) Surface modification of poly(lactic acid) by UV/Ozone Irradiation. Fiber Polym 9(6):674–678CrossRef

39.

Gutierrez-Villarreal MH, Ulloa-Hinjosa MG, Gaona-Lozano JG (2008) Surface functionalization of poly(lactic acid) film by UV-photografting of N-vinylpyrrolidone. J Appl Polym Sci 110:163–169CrossRef

40.

Jordá-Vilaplana A, Fombuena V, García-García D, Samper MD, Sánchez-Nácher L (2014) Surface modification of polylactic acid (PLA) by air atmospheric plasma treatment. Eur Polym J 58:23–33CrossRef

41.

Slepička P, Kasálková NS, Stránská E, Bačáková L, Švorčík V (2013) Surface characterization of plasma treated polymers for applications as biocompatible carriers. Express Polym Lett 7(6):535–545CrossRef

42.

Leonard DJ, Pick LT, Farrar DF, Dickson GR, Orr JF, Buchanan FJ (2009) The modification of PLA and PLGA using electron-beam radiation. J Biomed Mater Res A 89(3):567–574CrossRef

43.

III Owens DE, Peppas NA (2006) Opsonization, biodistribution and pharmacokinetics of polymeric nanoparticles. Int J Pharm 307:93–102CrossRef

44.

Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V (2012) PLGA-based nanoparticles: an overview. J Control Release 161:505–522CrossRef

45.

Zhang X, Wyss UP, Pichora D, Goosen MFA (1994) An investigation of poly(lactic acid) degradation. J Bioact Compat Pol 9:80–100CrossRef

46.

Tsuji H, Nakahara K (2002) Poly(L-lactide). IX. Hydrolysis in acid media. J Appl Polym Sci 86:186–194CrossRef

47.

Ma Z, Gao C, Gong Y, Ji J, Shen J (2002) Immobilization of natural macromolecules on poly-L-lactic acid membrane surface in order to improve its cytocompatibility. J Biomed Mater Res A 63(6):838–847CrossRef

48.

Lasprilla AJR, Martinez GAR, Lunelli BH, Jardini AL, Filho RM (2010) Synthesis and characterization of poly (lactic acid) for use in biomedical field. J Chem Eng 24:985–990

49.

Orozco VH, Brostow W, Chonkaew W, Lopez BL (2009) Preparation and characterization of poly(lactic acid)- g-maleic anhydride + starch blends. Macromol Symp 277(1):69–80CrossRef

50.

Nam YS, Yoon JJ, Lee JG, Park TG (1999) Adhesion behaviours of hepatocytes cultured onto biodegradable polymer surface modified by alkali hydrolysis process. J Biomater Sci Polym Ed 1:1145–1158

51.

Williams D (2014) Essential biomaterials science: Cambridge texts in biomedical engineering. Cambridge University Press, Cambridge

52.

Stamm M (2008) Polymer surface and interface characterization techniques. In: Stamm M (ed) Polymer surfaces and interfaces: characterization, modification and applications, vol 1, 1st edn. Springer, Berlin, pp 1–16CrossRef

53.

Lim JY, Shaughnessy MC, Zhou Z, Noh H, Vogler EA, Donahue HJ (2008) Surface energy effects on osteoblast spatial growth and mineralization. Biomaterials 29:1776–1784CrossRef

54.

Chau TT, Bruckard WJ, Koh PTL, Nguyen AV (2009) A review of factors that affect contact angle and implications for flotation practice. Adv Colloid Interface Sci 150:106–115CrossRef

55.

Sabee MMS, Kamalaldin NA, Yahaya BH, Abdul Hamid ZA (2016) Characterization and in vitro study of surface modified PLA microspheres treated with NaOH. J Polym Mater 33(1):191–200

56.

Boyan BD, Hummert TW, Dean DD, Schwartz Z (1996) Role of material surfaces in regulating bone and cartilage cell response. Biomatererials 17:137–146CrossRef

57.

Xu Q, Crossley A, Czernuzka J (2009) Preparation and characterization of negatively charged poly(lactic-co-cylcolic acid) microspheres. J Pharm Sci 98(7):2377–2389CrossRef

58.

Gref R, Miralles G, Dellacherie E (1999) Polyoxyethylene-coated nanospheres: effect of coating on zeta potential and phagocytosis. Polym Int 48(4):251–256CrossRef

59.

Dong Y, Feng S-S (2004) Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. Biomaterials 25(14):2843–2849CrossRef

60.

Pomogailo AD, Dzhardimalieva GI, Kestelman VN (2010) Macromolecular metal carboxylates and their nanocomposites. In: Hull R, Jagadish C, Osgood JRM, Parisi J, Wang Z, Warlimont H (eds) Materials science. Springer, New York

61.

Sawada K, Malchesky PS, Guidabaldi JM, Sueoka A, Shimoyama T (1993) In vitro evaluation of a relationship between human serum-material interaction. ASAIO J 39(4):910–917

62.

Croll TI, O’Connor AJ, Stevens GW, Cooper-White JJ (2004) Controllable surface modification of poly (lactic-co-glycolic acid)(PLGA) by hydrolysis or aminolysis I: physical, chemical, and theoretical aspects. Biomacromolecules 5(2):463–473CrossRef

63.

Shah A, Shah S, Mani G, Wenke J, Agrawal M (2011) Endothelial cell behaviour on gas-plasma-treated PLA surfaces: the roles of surface chemistry and roughness. J Tissue Eng Regen Med 5(4):301–312CrossRef

64.

Burkinshaw SM (1995) Chemical principles of synthetic fibre dyeing, 1st edn. Blackie Academic & Professional, BishopbriggsCrossRef

65.

Zeronian SH, Collins FTIMJ (2009) Surface modification of polyester by alkaline treatments. Text Prog 20(2):1–26CrossRef

66.

Tsuji H, Ikada Y (1998) Properties and morphology of poly(l-lactide). II. Hydrolysis in alkaline solution. J Polym Sci A Polym Chem 36:59–66CrossRef

67.

Schliecker G, Schmidt C, Fuchs S, Kissel T (2003) Characterization of a homologous series of D, L-lactic acid oligomers; a mechanistic study on the degradation kinetics in vitro. Biomaterials 24:3835–3844CrossRef

68.

Li SM, Garreau H, Vert M (1990) Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acid) in aqueous media. Part 1: poly(DL-lactic acid). J Mater Sci Mater Med 1(4):198–206CrossRef

69.

van Nostrum CF, Veldhuis TF, Bos GW, Hennink WE (2004) Hydrolytic degradation of oligo(latic acid): a kinetic and mechanistic study. Polymer 45:6779–6787CrossRef

70.

De Jong SJ, Arias ER, Rijkers DTS, Van Nostrum C (2001) New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer 42:2795–2802CrossRef

71.

Braud C, Devarieus R, Garreau H, Vert M (1996) Capillary electrophoresis to analyze water-soluble oligo(hydroxyacids) issued from degraded or biodegraded aliphatic polyester. J Environ Polym Degrad 4(3):135–148CrossRef

72.

Schliecker G, Schmidt C, Fuchs S, Wombacher R, Kissel T (2003) Hydrolytic degradation of poly (lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. Int J Pharm 266(1):39–49CrossRef

Titel: Preparation and optimization of surface-engineered poly(lactic acid) microspheres as a drug delivery device
verfasst von: Z. A. Abdul Hamid
C. Y. Tham
Z. Ahmad
Publikationsdatum: 18.12.2017
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 7/2018
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-017-1840-9

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