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01-01-2015 | Original Paper

Preparation, characterization, in vitro release, and pharmacokinetic studies of curcumin-loaded mPEG–PVL nanoparticles

Authors: Zhimei Song, Wenxia Zhu, Fengying Yang, Na Liu, Runliang Feng

Published in: Polymer Bulletin | Issue 1/2015

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Abstract

Curcumin shows several pharmacological activities with low toxicity, but its low water solubility limits its usage. To overcome these drawback, methoxy poly(ethylene glycol)-b-poly (\(\delta\)-valerolactone) was synthesized through ring-opening polymerization with mPEG and \(\delta\)-valerolactone as raw materials and hydrochloride ethyl ether as catalyst. The nanoparticles were developed by thin-film hydration and used as the delivery system for curcumin. The pharmacokinetics, in vitro release and safety of curcumin-loaded nanoparticles were evaluated. The results showed that nanoparticles had high drug-loading capacity (11.70 %) and entrapment efficiency (92.66 %). The water solubility of curcumin was increased to 1.851 mg/mL, which was approximately 1.73 × 10⁵ times higher than that of free curcumin. The plasma AUC_0–∞ and V _z of curcumin-loaded nanoparticles were 3.60- and 4.56-fold higher than that of curcumin control solution, respectively. The CL_z of curcumin-loaded nanoparticles was decreased by 3.60-fold. The MRT_0–∞ changed from 0.284 to 4.657 h. Hemolysis test results revealed that the mPEG–PVL was safe for intravenous injection. These results clearly showed that the curcumin-loaded nanoparticles were suitable to be a delivery vehicle for curcumin.

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Title: Preparation, characterization, in vitro release, and pharmacokinetic studies of curcumin-loaded mPEG–PVL nanoparticles
Authors: Zhimei Song
Wenxia Zhu
Fengying Yang
Na Liu
Runliang Feng
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 1/2015
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-014-1260-9

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