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Journal of Nanoparticle Research

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01-12-2017 | Research Paper

Reduction-responsive interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry for drug controlled release

Authors: Yu Dai, Hongquan Wang, Xiaojin Zhang

Published in: Journal of Nanoparticle Research | Issue 12/2017

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Abstract

To improve the stability of polymeric micelles, here we describe interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry. The formation of interlayer-crosslinked micelles was investigated and confirmed by proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, and fluorescence spectroscopy. The morphology of un-crosslinked micelles and crosslinked micelles observed by transmission electron microscope is both uniform nano-sized spheres (approximately 20 nm). The crosslinking enhances the stability of polymeric micelles and improves the drug loading capacity of polymeric micelles. The interlayer-crosslinked micelles prepared from star-shaped copolymer and a crosslinker containing a disulfide bond are reduction-responsive and can release the drug quickly in the presence of the reducing agents such as glutathione (GSH).

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Brantley JN, Bailey CB, Wiggins KM, Keatinge-Clayth AT, Bielawski CW (2013) Mechanobiochemistry: harnessing biomacromolecules for force-responsive materials. Polym Chem 4(14):3916–3928. https://doi.org/10.1039/c3py00001j CrossRef

Cabral H, Kataoka K (2014) Progress of drug-loaded polymeric micelles into clinical studies. J Control Release 190:465–476. https://doi.org/10.1016/j.jconrel.2014.06.042 CrossRef

Cai XQ, Liu MR, Zhang C, Sun DQ, Zhai GX (2016) pH-responsive copolymers based on pluronic P123-poly(beta-amino ester): synthesis, characterization and application of copolymer micelles. Colloids Surf B Biointerfaces 142:114–122. https://doi.org/10.1016/j.colsurfb.2016.02.033 CrossRef

Cheng R, Feng F, Meng FH, Deng C, Feijen J, Zhong ZY (2011) Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J Control Release 152(1):2–12. https://doi.org/10.1016/j.jconrel.2011.01.030 CrossRef

Cheng YL et al (2013) Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polym Chem 4(13):3851–3858. https://doi.org/10.1039/c3py00364g CrossRef

Dai Y, Wang HQ, Zhang XJ (2017) Polyion complex micelles prepared by self-assembly of block-graft polycation and hyperbranched polyanion. J Nanopart Res 19(9):298. https://doi.org/10.1007/s11051-017-3997-1 CrossRef

Dai Y, Yu P, Zhang XJ, Zhuo RX (2016) Gold nanoparticles stabilized by amphiphilic hyperbranched polymers for catalytic reduction of 4-nitrophenol. J Catal 337:65–71. https://doi.org/10.1016/j.jcat.2016.01.014 CrossRef

Dai Y, Zhang XJ (2017) Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release. J Nanopart Res 19(5):164. https://doi.org/10.1007/s11051-017-3866-y CrossRef

Deng C, Jiang YJ, Cheng R, Meng FH, Zhong ZY (2012) Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: promises, progress and prospects. Nano Today 7(5):467–480. https://doi.org/10.1016/j.nantod.2012.08.005 CrossRef

Gao HF (2012) Development of star polymers as unimolecular containers for nanomaterials. Macromol Rapid Commun 33(9):722–734. https://doi.org/10.1002/marc.201200005 CrossRef

Han Y, Li JJ, Zan MH, Luo SZ, Ge ZS, Liu SY (2014) Redox-responsive core cross-linked micelles based on cypate and cisplatin prodrugs-conjugated block copolymers for synergistic photothermal-chemotherapy of cancer. Polym Chem 5(11):3707–3718. https://doi.org/10.1039/c4py00064a CrossRef

Hu JM, Zhang GQ, Liu SY (2012) Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels. Chem Soc Rev 41(18):5933–5949. https://doi.org/10.1039/c2cs35103j CrossRef

Kolb HC, Finn MG, Sharpless KB (2001) Click chemistry: diverse chemical function from a few good reactions. Angew Chem Int Edit 40(11):2004–2021. https://doi.org/10.1002/1521-3773(20010601)40:11<2004::aid-anie2004>3.0.co;2-5 CrossRef

Lai TC, Cho H, Kwon GS (2014) Reversibly core cross-linked polymeric micelles with pH- and reduction-sensitivities: effects of cross-linking degree on particle stability, drug release kinetics, and anti-tumor efficacy. Polym Chem 5(5):1650–1661. https://doi.org/10.1039/c3py01112g CrossRef

Lallana E, Sousa-Herves A, Fernandez-Trillo F, Riguera R, Fernandez-Megia E (2012) Click chemistry for drug delivery nanosystems. Pharm Res 29(1):1–34. https://doi.org/10.1007/s11095-011-0568-5 CrossRef

Lallana E, Tirelli N (2013) Oxidation-responsive polymers: which groups to use, how to make them, what to expect from them (biomedical applications). Macromol Chem Phys 214(2):143–158. https://doi.org/10.1002/macp.201200502 CrossRef

Lin SJ, Theato P (2013) CO2-responsive polymers. Macromol Rapid Commun 34(14):1118–1133. https://doi.org/10.1002/marc.201300288 CrossRef

Liu J, Jiang XL, Xu L, Wang XM, Hennink WE, Zhuo RX (2010) Novel reduction-responsive cross-linked polyethylenimine derivatives by click chemistry for nonviral gene delivery. Bioconjug Chem 21(10):1827–1835. https://doi.org/10.1021/bc100191r CrossRef

Luo YL, Yang XL, Xu F, Chen YS, Zhang B (2014) Thermosensitive PNIPAM-b-HTPB block copolymer micelles: molecular architectures and camptothecin drug release. Colloids Surf B Biointerfaces 114:150–157. https://doi.org/10.1016/j.colsurfb.2013.09.043 CrossRef

Ma RJ, Shi LQ (2014) Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery. Polym Chem 5(5):1503–1518. https://doi.org/10.1039/c3py01202f CrossRef

Moses JE, Moorhouse AD (2007) The growing applications of click chemistry. Chem Soc Rev 36(8):1249–1262. https://doi.org/10.1039/b613014n CrossRef

O’Reilly RK, Joralemon MJ, Wooley KL, Hawker CJ (2005) Functionalization of micelles and shell cross-linked nanoparticles using click chemistry. Chem Mat 17(24):5976–5988. https://doi.org/10.1021/cm051047s CrossRef

Owen SC, Chan DPY, Shoichet MS (2012) Polymeric micelle stability. Nano Today 7(1):53–65. https://doi.org/10.1016/j.nantod.2012.01.002 CrossRef

Rosler A, Vandermeulen GWM, Klok HA (2012) Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv Drug Deliv Rev 64:270–279. https://doi.org/10.1016/j.addr.2012.09.026 CrossRef

Sun HL, Meng FH, Cheng R, Deng C, Zhong ZY (2014) Reduction-responsive polymeric micelles and vesicles for triggered intracellular drug release. Antioxid Redox Signal 21(5):755–767. https://doi.org/10.1089/ars.2013.5733 CrossRef

Tarassoli SP, de Pinillos Bayona AM, Pye H, Mosse CA, Callan JF, MacRobert A, McHale AP, Nomikou N (2017) Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy. Nanotechnology 28(5):055101. https://doi.org/10.1088/1361-6528/28/5/055101 CrossRef

Texter J (2012) Anion responsive imidazolium-based polymers. Macromol Rapid Commun 33(23):1996–2014. https://doi.org/10.1002/marc.201200525 CrossRef

Thevenot J, Oliveira H, Sandre O, Lecommandoux S (2013) Magnetic responsive polymer composite materials. Chem Soc Rev 42(17):7099–7116. https://doi.org/10.1039/c3cs60058k CrossRef

Thurmond KB, Kowalewski T, Wooley KL (1996) Water-soluble knedel-like structures: the preparation of shell-cross-linked small particles. J Am Chem Soc 118(30):7239–7240. https://doi.org/10.1021/ja961299h CrossRef

van Nostrum CF (2011) Covalently cross-linked amphiphilic block copolymer micelles. Soft Matter 7(7):3246–3259. https://doi.org/10.1039/c0sm00999g CrossRef

Venkataraman S, Hedrick JL, Ong ZY, Yang C, Ee PLR, Hammond PT, Yang YY (2011) The effects of polymeric nanostructure shape on drug delivery. Adv Drug Deliv Rev 63(14-15):1228–1246. https://doi.org/10.1016/j.addr.2011.06.016 CrossRef

Wang H, Wang XS, Winnik MA, Manners I (2008) Redox-mediated synthesis and encapsulation of inorganic nanoparticles in shell-cross-linked cylindrical polyferrocenylsilane block copolymer micelles. J Am Chem Soc 130(39):12921–12930. https://doi.org/10.1021/ja8028558 CrossRef

Wei RR, Cheng L, Zheng M, Cheng R, Meng FH, Deng C, Zhong ZY (2012) Reduction-responsive disassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release. Biomacromolecules 13(8):2429–2438. https://doi.org/10.1021/bm3006819 CrossRef

Yashima E, Maeda K (2008) Chirality-responsive helical polymers. Macromolecules 41(1):3–12. https://doi.org/10.1021/ma071453s CrossRef

Zhang WL, Choi HJ (2014) Stimuli-responsive polymers and colloids under electric and magnetic fields. Polymers 6(11):2803–2818. https://doi.org/10.3390/polym6112803 CrossRef

Zhang XJ, Dong H, Fu SL, Zhong ZL, Zhuo RX (2016a) Redox-responsive micelles with cores crosslinked via click chemistry. Macromol Rapid Commun 37(12):993–997. https://doi.org/10.1002/marc.201600049 CrossRef

Zhang XJ, Li Y, Chen YE, Chen JH, Ma PX (2016b) Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Nat Commun 7:10376. https://doi.org/10.1038/ncomms10376 CrossRef

Zhang XJ, Wang HQ, Dai Y (2017) Interlayer-crosslinked micelles prepared from star-shaped copolymers via click chemistry for sustained drug release. Nanotechnology 28(20):205601. https://doi.org/10.1088/1361-6528/aa6907 CrossRef

Zhao YZ, Du LN, Lu CT, Jin YG, Ge SP (2013) Potential and problems in ultrasound-responsive drug delivery systems. Int J Nanomedicine 8:1621–1633. https://doi.org/10.2147/ijn.s43589

Zhu ZX (2013) Effects of amphiphilic diblock copolymer on drug nanoparticle formation and stability. Biomaterials 34(38):10238–10248. https://doi.org/10.1016/j.biomaterials.2013.09.015 CrossRef

Title: Reduction-responsive interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry for drug controlled release
Authors: Yu Dai
Hongquan Wang
Xiaojin Zhang
Publication date: 01-12-2017
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 12/2017
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4082-5

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