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Journal of Nanoparticle Research

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01.12.2017 | Research Paper

Reduction-responsive interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry for drug controlled release

verfasst von: Yu Dai, Hongquan Wang, Xiaojin Zhang

Erschienen in: Journal of Nanoparticle Research | Ausgabe 12/2017

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Abstract

To improve the stability of polymeric micelles, here we describe interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry. The formation of interlayer-crosslinked micelles was investigated and confirmed by proton nuclear magnetic resonance, Fourier-transform infrared spectroscopy, and fluorescence spectroscopy. The morphology of un-crosslinked micelles and crosslinked micelles observed by transmission electron microscope is both uniform nano-sized spheres (approximately 20 nm). The crosslinking enhances the stability of polymeric micelles and improves the drug loading capacity of polymeric micelles. The interlayer-crosslinked micelles prepared from star-shaped copolymer and a crosslinker containing a disulfide bond are reduction-responsive and can release the drug quickly in the presence of the reducing agents such as glutathione (GSH).

Vorheriger Artikel The structural and magnetic investigation of (x) BiFe0.95Co0.05O3: (1-x) La0.7Ca0.3MnO3 composites

Nächster Artikel Förster resonance energy transfer in hybrid associates of colloidal Ag2S quantum dots with thionine molecules

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Titel: Reduction-responsive interlayer-crosslinked micelles prepared from star-shaped copolymer via click chemistry for drug controlled release
verfasst von: Yu Dai
Hongquan Wang
Xiaojin Zhang
Publikationsdatum: 01.12.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 12/2017
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4082-5

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