Top

Published in:

01-11-2018 | Research Paper

Synthesis, characterization, and toxicity of hollow gold nanoshells

Authors: Sayma Adriana Rodriguez-Montelongo, Jesus Gonzalez-Hernandez, Abel Hurtado Macias, Ana Sonia Silva-Ramirez, Claudia G. Castillo Martin del Campo, Jose Manuel Gutierrez-Hernandez, Facundo Ruiz, Omar Gonzalez-Ortega

Published in: Journal of Nanoparticle Research | Issue 11/2018

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Hollow gold nanoshells (HGN) with a diameter of 50–70 nm and tunable optical properties within the near-infrared region were synthesized from a substitution reaction using a sacrificial template, in which the morphological properties of the HGN were affected by the synthesis conditions. Using EDX line scan, the composition of the structure was determined to verify if the sacrificial template is completely consumed or residues remain after the chemical synthesis, obtaining that the final HGN structure contains about 11% of the remaining silver that showed no significant effect on the cell viability of a hNS1 cell line, but resulted as toxic on a C6 glioma cell line at high concentrations. The photothermal properties were evaluated using a NIR laser, which despite its low power showed the conversion of light into heat. This study was conducted to evaluate the potential of these nanostructures as therapeutic agents with an emphasis on toxicity.

previous article The synthesis of graphene-TiO2/g-C3N4 super-thin heterojunctions with enhanced visible-light photocatalytic activities

next article Effect of the size on the aggregation and sedimentation of graphene oxide in seawaters with different salinities

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Abdollahi SN, Naderi M, Amoabediny G (2013) Synthesis and characterization of hollow gold nanoparticles using silica spheres as templates. Colloids Surf A Physicochem Eng Asp 436:1069–1075. https://doi.org/10.1016/j.colsurfa.2013.08.028 CrossRef

Allabashi R, Stach W, De La Escosura-Muñiz A et al (2009) ICP-MS: a powerful technique for quantitative determination of gold nanoparticles without previous dissolving. J Nanopart Res 11:2003–2011. https://doi.org/10.1007/s11051-008-9561-2 CrossRef

Au L, Zheng D, Zhou F, Li ZY, Li X, Xia Y (2008) A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells. ACS Nano 2:1645–1652. https://doi.org/10.1021/nn800370j CrossRef

Bardhan R, Lal S, Joshi A, Halas NJ (2011) Theranostic nanoshells: from probe design to imaging and treatment of cancer. Acc Chem Res 44:936–946. https://doi.org/10.1021/ar200023x CrossRef

Chen J, Wiley B, Li ZY, Campbell D, Saeki F, Cang H, Au L, Lee J, Li X, Xia Y (2005) Gold nanocages: engineering their structure for biomedical applications. Adv Mater 17:2255–2261. https://doi.org/10.1002/adma.200500833 CrossRef

Chen J, Glaus C, Laforest R, Zhang Q, Yang M, Gidding M, Welch MJ, Xia Y (2010) Gold nanocages as photothermal transducers for cancer treatment. Small 6:811–817. https://doi.org/10.1002/smll.200902216 CrossRef

Chien CC, Cheng CC, Chen HH, Hwu Y, Chu YS, Petibois C, Chen A, Ching YT, Margaritondo G (2012) X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues. Anal Bioanal Chem 404:1287–1296CrossRef

Doan N, Kontturi K, Johans C (2010) Directing oxidation of cobalt nanoparticles with the capping ligand. J Colloid Interface Sci 350:126–131. https://doi.org/10.1016/j.jcis.2010.06.024 CrossRef

Gabudean AM, Lerouge F, Gallavardin T, Iosin M, Zaiba S, Maury O, Baldeck PL, Andraud C, Parola S (2011) Synthesis and optical properties of dyes encapsulated in gold hollow nanoshells. Opt Mater (Amst) 33:1377–1381. https://doi.org/10.1016/j.optmat.2011.03.017 CrossRef

Han C, Yang J, Gu J (2018) Immobilization of silver nanoparticles in Zr-based MOFs: induction of apoptosis in cancer cells. J Nanopart Res 20. https://doi.org/10.1007/s11051-018-4187-5

Hao E, Li SY, Bailey RC, Zou S, Schatz GC, Hupp JT (2004) Optical properties of metal nanoshells. J Phys Chem B 108:1224–1229. https://doi.org/10.1021/jp036301n CrossRef

Huang X, El-Sayed MA (2011) Plasmonic photo-thermal therapy (PPTT). Alex J Med 47:1–9. https://doi.org/10.1016/j.ajme.2011.01.001 CrossRef

Jaque D, Martínez Maestro L, del Rosal B, Haro-Gonzalez P, Benayas A, Plaza JL, Martín Rodríguez E, García Solé J (2014) Nanoparticles for photothermal therapies. Nanoscale 6:9494–9530. https://doi.org/10.1039/c4nr00708e CrossRef

Karakoti AS, Das S, Thevuthasan S, Seal S (2011) PEGylated inorganic nanoparticles. Angew Chem Int Ed 50:1980–1994. https://doi.org/10.1002/anie.201002969 CrossRef

Kim MH, Lu X, Wiley B, Lee EP, Xia Y (2008) Morphological evolution of single-crystal Ag nanospheres during the galvanic replacement reaction with HAuCl4. J Phys Chem C 112:7872–7876. https://doi.org/10.1021/jp711662f CrossRef

Kroll A, Pillukat MH, Hahn D, Schnekenburger J (2012) Interference of engineered nanoparticles with in vitro toxicity assays. Arch Toxicol 86:1123–1136. https://doi.org/10.1007/s00204-012-0837-z CrossRef

Kumar R, Maitra AN, Patanjali PK, Sharma P (2005) Hollow gold nanoparticles encapsulating horseradish peroxidase. Biomaterials 26:6743–6753. https://doi.org/10.1016/j.biomaterials.2005.04.045 CrossRef

Langille MR, Personick ML, Zhang J, Mirkin CA (2011) Bottom-up synthesis of gold octahedra with tailorable hollow features. J Am Chem Soc 133:10414–10417. https://doi.org/10.1021/ja204375d CrossRef

Li Z, Xue-Feng Y, Xiao-Feng F, Zhong-Hua H, Kai-Yang L (2008) Surface plasmon resonance and field enhancement of Au/Ag alloyed hollow nanoshells. Chin Phys Lett 25:1776–1779. https://doi.org/10.1088/0256-307X/25/5/069 CrossRef

Liang H, Wan L, Bai C, Jiang L (2005) Gold hollow nanospheres: tunable surface plasmon resonance controlled by interior-cavity sizes. J Phys Chem B 109:7795–7800. https://doi.org/10.1021/jp045006f CrossRef

Lindley SA, Cooper JK, Rojas-Andrade MD, Fung V, Leahy CJ, Chen S, Zhang JZ (2017) Highly tunable hollow gold nanospheres: gaining size control and uniform galvanic exchange of sacrificial cobalt boride scaffolds. ACS Appl Mater Interfaces 10:12992–13001. https://doi.org/10.1021/acsami.8b00726 CrossRef

Loo C, Lin A, Hirsch L, Lee M, Barton J, Halas N, West J, Drezek R (2004) Nanoshell-enabled photonics-based imaging and therapy of cancer. Technol Cancer Res Treat 3:33–40CrossRef

Lu X, Chen J, Skrabalak SE, Xia Y (2008) Galvanic replacement reaction: a simple and powerful route to hollow and porous metal nanostructures. Proc Inst Mech Eng Part N J Nanoeng Nanosyst 221:1–16. https://doi.org/10.1243/17403499JNN111 CrossRef

Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C (2009) Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog - conjugated hollow gold nanospheres. Clin Cancer Res 15:876–886. https://doi.org/10.1158/1078-0432.CCR-08-1480 CrossRef

Lu W, Huang Q, Ku G, Wen X, Zhou M, Guzatov D, Brecht P, Su R, Oraevsky A, Wang LV, Li C (2010) Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials 31:2617–2626. https://doi.org/10.1016/j.biomaterials.2009.12.007 CrossRef

Lux F, Lerouge F, Bosson J, Lemercier G, Andraud C, Vitrant G, Baldeck PL, Chassagneux F, Parola S (2009) Gold hollow spheres obtained using an innovative emulsion process: towards multifunctional Au nanoshells. Nanotechnology 20:355603. https://doi.org/10.1088/0957-4484/20/35/355603 CrossRef

Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C (2008) In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7:1730–1739. https://doi.org/10.1158/1535-7163.MCT-08-0016 CrossRef

Melancon MP, Zhou M, Li C (2011) Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Acc Chem Res 44:947–956. https://doi.org/10.1021/ar200022e CrossRef

O’Neal DP, Hirsch LR, Halas NJ et al (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209:171–176. https://doi.org/10.1016/j.canlet.2004.02.004 CrossRef

Olson TY, Schwartzberg AM, Orme CA, Talley CE, O'Connell B, Zhang JZ (2008) Hollow gold-silver double-shell nanospheres: structure, optical absorption, and surface-enhanced raman scattering. J Phys Chem C 112:6319–6329. https://doi.org/10.1021/jp7116714 CrossRef

Peña-Rodríguez O, González Pérez PP, Pal U (2011) MieLab: a software tool to perform calculations on the scattering of electromagnetic waves by multilayered spheres. Int J Spectrosc 2011:1–10. https://doi.org/10.1155/2011/583743 CrossRef

Pfaller T, Colognato R, Nelissen I, Favilli F, Casals E, Ooms D, Leppens H, Ponti J, Stritzinger R, Puntes V, Boraschi D, Duschl A, Oostingh GJ (2010) The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. Nanotoxicology 4:52–72. https://doi.org/10.3109/17435390903374001 CrossRef

Poudel BK, Gupta B, Ramasamy T, Thapa RK, Pathak S, Oh KT, Jeong JH, Choi HG, Yong CS, Kim JO (2017) PEGylated thermosensitive lipid-coated hollow gold nanoshells for effective combinational chemo-photothermal therapy of pancreatic cancer. Colloids Surf B 160:73–83. https://doi.org/10.1016/j.colsurfb.2017.09.010 CrossRef

Preciado-Flores S, Wang D, Wheeler DA, Newhouse R, Hensel JK, Schwartzberg A, Wang L, Zhu J, Barboza-Flores M, Zhang JZ (2011) Highly reproducible synthesis of hollow gold nanospheres with near infrared surface plasmon absorption using PVP as stabilizing agent. J Mater Chem 21:2344–2350. https://doi.org/10.1039/c0jm03690k CrossRef

Qin Y, Ji X, Jing J, Liu H, Wu H, Yang W (2010) Size control over spherical silver nanoparticles by ascorbic acid reduction. Colloids Surf A Physicochem Eng Asp 372:172–176. https://doi.org/10.1016/j.colsurfa.2010.10.013 CrossRef

Schwartzberg AM, Olson TY, Talley CE, Zhang JZ (2006) Synthesis, characterization, and tunable optical properties of hollow gold nanospheres. J Phys Chem B 110:19935–19944. https://doi.org/10.1021/jp062136a CrossRef

Shahjamali MM, Bosman M, Cao S, Huang X, Saadat S, Martinsson E, Aili D, Tay YY, Liedberg B, Loo SCJ, Zhang H, Boey F, Xue C (2012) Gold coating of silver nanoprisms. Adv Funct Mater 22:849–854. https://doi.org/10.1002/adfm.201102028 CrossRef

Skrabalak SE, Chen J, Sun Y, Lu X, Au L, Cobley CM, Xia Y (2008) Gold nanocages: synthesis, properties and applications. Acc Chem Res 41:1587–1595. https://doi.org/10.1021/ar800018v CrossRef

Sun Y, Xia Y (2002) Increased sensitivity of surface plasmon resonance of gold nanoshells compared to that of gold solid colloids in response to environmental changes. Anal Chem 74:5297–5305. https://doi.org/10.1021/ac0258352 CrossRef

Sun Y, Mayers BT, Xia Y (2002) Template-engaged replacement reaction: a one-step approach to the large-scale synthesis of metal nanostructures with hollow interiors. Nano Lett 2:481–485. https://doi.org/10.1021/nl025531v CrossRef

Sun Y, Mayers B, Xia Y (2003) Metal nanostructures with hollow interiors. Adv Mater 15:641–646. https://doi.org/10.1002/adma.200301639 CrossRef

Villa A, Snyder EY, Vescovi A, Martı́nez-Serrano A (2000) Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol 161:67–84. https://doi.org/10.1006/exnr.1999.7237 CrossRef

Villa A, Navarro-Galve B, Bueno C, Franco S, Blasco ḾA, Martinez-Serrano A (2004) Long-term molecular and cellular stability of human neural stem cell lines. Exp Cell Res 294:559–570. https://doi.org/10.1016/j.yexcr.2003.11.025 CrossRef

Vongsavat V, Vittur BM, Bryan WW, Kim JH, Lee TR (2011) Ultrasmall hollow gold-silver nanoshells with extinctions strongly red-shifted to the near-infrared. ACS Appl Mater Interfaces 3:3616–3624. https://doi.org/10.1021/am2008322 CrossRef

Wu G, Mikhailovsky A, Khant HA, Fu C, Chiu W, Zasadzinski JA (2008) Remotely triggered liposomal release by near-infrared light absorption via hollow gold nanoshells. J Am Chem Soc 130:8175–8177. https://doi.org/10.1021/ja802656d CrossRef

Xia Y, Campbell DJ (2007) Plasmons: why should we care? J Chem Educ 84:91. https://doi.org/10.1021/ed084p91 CrossRef

You J, Zhang G, Li C (2010) Exceptionally high payload of doxorubicin in hollow gold nanospheres for mear-infrared light-triggered drug release. ACS Nano 4:1033–1041. https://doi.org/10.1021/nn901181c CrossRef

Yu M, Guo F, Wang J, Tan F, Li N (2016) A pH-driven and photoresponsive nanocarrier: remotely-controlled by near-infrared light for stepwise antitumor treatment. Biomaterials 79:25–35. https://doi.org/10.1016/j.biomaterials.2015.11.049 CrossRef

Zhang JZ (2010) Biomedical applications of shape-controlled plasmonic nanostructures: a case study of hollow gold nanospheres for photothermal ablation therapy of cancer. J Phys Chem Lett 1:686–695. https://doi.org/10.1021/jz900366c CrossRef

Zhang Q, Xie J, Yu Y, Lee JY (2010) Monodispersity control in the synthesis of monometallic and bimetallic quasi-spherical gold and silver nanoparticles. Nanoscale 2:1962–1975. https://doi.org/10.1039/c0nr00155d CrossRef

Zhang K, Holloway T, Wingfield A, Pradhan J, Cao W, K. Pradhan A (2011) Hollow gold nanospheres: growth, morphology, composition and absorption characteristics. Micro Nanosyst 3:76–82. https://doi.org/10.2174/1876402911103010076 CrossRef

Title: Synthesis, characterization, and toxicity of hollow gold nanoshells
Authors: Sayma Adriana Rodriguez-Montelongo
Jesus Gonzalez-Hernandez
Abel Hurtado Macias
Ana Sonia Silva-Ramirez
Claudia G. Castillo Martin del Campo
Jose Manuel Gutierrez-Hernandez
Facundo Ruiz
Omar Gonzalez-Ortega
Publication date: 01-11-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4420-2

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 11/2018

Reduced graphene oxide-based broad band photodetector and temperature sensor: effect of gas adsorption on optoelectrical properties

Tuning Pt–Cu nanostructures by bromide ions and their superior electrocatalytic activities for methanol oxidation reaction

Impedance sensing platform for 4,4′-dibromobiphenyl based on a molecularly imprinted polymerized ionic liquid film/gold nanoparticle-modified glassy carbon electrode

Systematic parametric investigation on the CVD process of polysiloxane nano- and microstructures

Determining surface chemical composition of silver nanoparticles during sulfidation by monitoring the ligand shell

Hydrothermally grown nano-manganese oxide on clinoptilolite for low-temperature propane-selective catalytic reduction of NOx

Premium Partners