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01-03-2014 | Research Paper

Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma

Authors: Erica Locatelli, Wolfgang Bost, Marc Fournelle, Jordi Llop, Larraitz Gil, Francesca Arena, Vito Lorusso, Mauro Comes Franchini

Published in: Journal of Nanoparticle Research | Issue 3/2014

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Abstract

Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.

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Title: Targeted polymeric nanoparticles containing gold nanorods: a therapeutic approach against glioblastoma
Authors: Erica Locatelli
Wolfgang Bost
Marc Fournelle
Jordi Llop
Larraitz Gil
Francesca Arena
Vito Lorusso
Mauro Comes Franchini
Publication date: 01-03-2014
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 3/2014
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-014-2304-7

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