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2018 | OriginalPaper | Chapter

Toward Ultrasensitive Surface Plasmon Resonance Sensors

Authors : Vitali Scherbahn, Shavkat Nizamov, Vladimir M. Mirsky

Published in: Label-Free Biosensing

Publisher: Springer International Publishing

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Abstract

Despite the history of application of surface plasmon resonance (SPR) for chemo- and biosensing being over 30 years long, the development of this technique is still in progress.
This review is focused on the technological aspects of further improvement of analytical performance of SPR transducers based on Kretschmann configuration. We describe basic measurement configurations, their improvements and optimizations, and their drawbacks and limitations. An importance of referencing in SPR sensors is highlighted. The referencing approaches are classified into the following domains: (1) macroscopic spatially separated referencing, (2) self-referencing based on micro-patterning, (3) in-place referencing, (4) spatiotemporal referencing, and (5) electrochemically assisted referencing. The underlying principles of these approaches, examples of their implementation, and resulting improvements of sensor performance are described. Finally, an analysis of SPR data and an extraction of affinity properties are discussed.

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Metadata
Title
Toward Ultrasensitive Surface Plasmon Resonance Sensors
Authors
Vitali Scherbahn
Shavkat Nizamov
Vladimir M. Mirsky
Copyright Year
2018
DOI
https://doi.org/10.1007/5346_2017_21

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