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2022 | Book

Introduction Read chapter Read first chapter

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals

Author: Dr. Yunjiao Zhang

Publisher: Springer Nature Singapore

Book Series : Springer Theses

Part of: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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About this book

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Table of Contents

Frontmatter
Chapter 1. Introduction
Abstract
In the past few decades, nanomaterials have caused a continuous and extensive research issue in different fields.
Yunjiao Zhang
Chapter 2. Successfully Obtained Short Peptides RE-1 Using Phage Display Technology
Abstract
Phage display technology uses the interaction between nanomaterials and phage display polypeptides, playing an important role in the selection of peptides on the surface of nanomaterials.
Yunjiao Zhang
Chapter 3. Binding Rare Earth Nano Materials with High Affinity and Forming Surface Coating
Abstract
In the previous chapter, it was proved that the phage REOB-1 with specific and high affinity binding to rare earth nanomaterials was screened by phage display technology. The binding of peptides on the surface with rare earth nanomaterials is sequence specific. However, many previous reports have shown that phage physical binding does not necessarily mean it can chemically bind synthesized peptides, so it is important to show that peptides can efficiently bind nanomaterials.
Yunjiao Zhang
Chapter 4. RE-1 Improves the Suspension Capacity of Rare Earth Nanomaterials in Water Well Reduction and Cell and Surface Interactions
Abstract
Rare earth up-conversion luminescent nanomaterials (UCN, UCP, UCN-S) emit light due to their unique up-conversion luminescence characteristics, to make a wide range of applications, after the field of biomedical chase. In order to further enhance the application of the materials themselves in various fields (especially in the field of biomedicine), the short peptides of specific conjugated thin soils for the conversion of luminescent nanomaterials were screened in this paper.
Yunjiao Zhang
Chapter 5. RE-1 Effectively Shields the Cell Self-Effect of Rare Earth Nanomaterials, Reduces Their Toxicity and Improves Their Biological Safety
Abstract
With the continuous development of the application of nanomaterials in the field of biomedicine, the study of the biological effects of nanomaterials has also become a hot spot in this field. As an important cellular biological effect of nanomaterials, cell autophagy has been paid more and more attention worldwide to study its process and effect. Studies have shown that many inorganic and organic nanomaterials can trigger autophagy in a variety of cells, so increasing the level of autophagy may be a universal response of cells to nanomaterials. However, numerous studies have shown that autophagy is a “double-edged sword”.
Yunjiao Zhang
Chapter 6. RGD-RE-1 Bifunctional Short Peptide Enhances the Interaction Between Rare Earth Nanomaterials and Cancer Cells and the Effect of Cell Autophagy
Abstract
In the previous chapter, we employed a large number of experiments to prove that the specific binding short peptide RE-1 can effectively shield the ability of materials to induce autophagy in cells and mice by reducing the non-specific interaction between rare earth nanomaterials and cells, as well as rare earth nanomaterials, and improve the biological safety of materials.
Yunjiao Zhang
Chapter 7. Summary and Outlook
Abstract
In this article, we demonstrated the feasibility of using phage display technology for surface engineering of nanomaterials.
Yunjiao Zhang
Metadata
Title
Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
Author
Dr. Yunjiao Zhang
Copyright Year
2022
Publisher
Springer Nature Singapore
Electronic ISBN
978-981-16-8166-0
Print ISBN
978-981-16-8165-3
DOI
https://doi.org/10.1007/978-981-16-8166-0

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