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2018 | OriginalPaper | Chapter

3.  Lab-on-a-chip Systems for Cellomics—Materials and Technology

Authors : Dominika Kalinowska, Katarzyna Tokarska, Ilona Grabowska-Jadach, Artur Dybko, Zbigniew Brzozka

Published in: Cardiac Cell Culture Technologies

Publisher: Springer International Publishing

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Abstract

The main advantage of the microsystems is their ability to imitate in vivo conditions which are missing in macroscale cell cultures. The materials which find applications in Lab-on-a-chip devices for cellomics, their properties, and microfabrication techniques are presented in this chapter. Such microfluidic devices are useful tools in many fields involving cell culture studies, e.g., cell trapping, counting or sorting, cell lysis and fusion, cultivation, and drug screening. Construction materials, not only the most commonly used poly(dimethyl siloxane) (PDMS) and glass, but also such polymers as polystyrene (PS), poly(methyl methacrylate) (PMMA), polycarbonate (PC), and cyclic olefin copolymer (COC), are presented. There are many materials which are utilized to create spatial arrangement of the cells in the developed microsystems. For this purpose, natural (e.g., collagen), synthetic (e.g., poly(ethylene glycol)—PEG), and hybrid (e.g., gelatin methacryloyl—GelMA) hydrogels as well as nanofibrous scaffolds are applied. We present short description and some examples of the usage of above materials. This chapter also describes the most common fabrication methods of Lab-on-a-chip (LOC) devices for cellomics. These considerations are extended to potential mass production of cell-based microsystems, using a range of materials. Adopting more time and cost-effective fabrication methods is critical for the integration of LOCs into mainstream applications, and therefore, factors such as quality control or device repeatability were detailed.

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previous chapter Microfluidic Systems
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Metadata
Title
Lab-on-a-chip Systems for Cellomics—Materials and Technology
Authors
Dominika Kalinowska
Katarzyna Tokarska
Ilona Grabowska-Jadach
Artur Dybko
Zbigniew Brzozka
Copyright Year
2018
Book
Cardiac Cell Culture Technologies

Print ISBN: 978-3-319-70684-9

Electronic ISBN: 978-3-319-70685-6

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-3-319-70685-6_3