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Polymer Science, Series D
Published in: Polymer Science, Series D 2/2023

01-06-2023

Microfluidic Synthesis of Oligohexamethylene Guanidine Hydrocitrate and Study of Its Antimicrobial Activity

Authors: D. O. Shatalov, I. S. Ivanov, A. V. Aydakova, D. A. Akhmetova, Yu. A. Koroleva, D. D. Kirilova, Yu. A. Azarova, P. I. Kurnosova, A. Yu. Dolgovskaya, O. A. Legon’kova, S. A. Kedik

Published in: Polymer Science, Series D | Issue 2/2023

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Abstract

Due to the growing problem of antibiotic resistance, the possibility of using alkylene guanidines as compounds exhibiting antimicrobial activity is discussed. Methods for the preparation of oligohexamethylene guanidine (OHMG) dihydrocarbonate using microfluidic technologies and the further synthesis of OHMG hydrocitrate are described. Structures of the compounds obtained were confirmed by 13С NMR spectroscopy, and the antimicrobial activity of OHMG hydrocitrate was evaluated.
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Metadata
Title
Microfluidic Synthesis of Oligohexamethylene Guanidine Hydrocitrate and Study of Its Antimicrobial Activity
Authors
D. O. Shatalov
I. S. Ivanov
A. V. Aydakova
D. A. Akhmetova
Yu. A. Koroleva
D. D. Kirilova
Yu. A. Azarova
P. I. Kurnosova
A. Yu. Dolgovskaya
O. A. Legon’kova
S. A. Kedik
Publication date
01-06-2023
Publisher
Pleiades Publishing
Published in
Polymer Science, Series D / Issue 2/2023
Print ISSN: 1995-4212
Electronic ISSN: 1995-4220
DOI
https://doi.org/10.1134/S1995421223020375

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