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Polymer Bulletin
Published in: Polymer Bulletin 6/2015

01-06-2015 | Original Paper

Preparation and characterization of chitosan–hydroxyapatite–glycopolymer/Cloisite 30 B nanocomposite for biomedical applications

Authors: Amal Amin, Heba Kandil, Hanem M. Awad, Mohamed Nader Ismail

Published in: Polymer Bulletin | Issue 6/2015

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Abstract

A new composite was synthesized from chitosan/hydroxyapatite and glycopolymer grafted onto a Cloisite 30B clay surface (CS/HAP/clay-Gh) in aqueous media via a solvent casting and evaporation method. Another composite containing chitosan/hydroxyapatite and pristine Cloisite 30B (CS/HAP/clay) was prepared and compared with the (CS/HAP/clay-Gh). The resulting composites were characterized using various analytical tools such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermal gravimetric analyses (TGA) and scanning electron microscopy (SEM). Water uptake capability or swelling was tested for each composite. The cytotoxicity of the resulting tri-component composites was tested against a breast carcinoma cell line (MCF-7), liver carcinoma cell line (HepG-2) and a normal human skin fibroblast cell line (BJ-1) by MTT [3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide] as well as LDH (lactate dehydrogenase) assay. The obtained preliminary results showed good properties for CS/HAP/clay-Gh on the way to be used in the future in the biomedical applications.
previous article Preparation and characterization of hybrid hydrogels composed of physically cross-linked gelatin and liquid-crystalline filamentous viruses
next article Synthesis of poly(vinyl alcohol-graft-lactic acid) copolymer and its application as medical anti-tissue adhesion thin film

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Metadata
Title
Preparation and characterization of chitosan–hydroxyapatite–glycopolymer/Cloisite 30 B nanocomposite for biomedical applications
Authors
Amal Amin
Heba Kandil
Hanem M. Awad
Mohamed Nader Ismail
Publication date
01-06-2015
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 6/2015
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-015-1351-2

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