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2019 | OriginalPaper | Buchkapitel

A Deep Learning Approach for Diagnosing Long QT Syndrome Without Measuring QT Interval

verfasst von : Habib Hajimolahoseini, Damian Redfearn, Andrew Krahn

Erschienen in: Advances in Artificial Intelligence

Verlag: Springer International Publishing

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Abstract

For decades, ECG segmentation and QT interval measurement have been two fundamental steps in ECG-based diagnosis of the long QT syndrome (LQTS). However, due to the subjective nature of the definition of Q and T wave boundaries and confusion with an adjacent U wave, it suffers from a high degree of inter- and intra-analyst variability. In this paper, without measuring the QT interval and extracting the ECG waves, we propose a convolutional neural network which receives the raw ECG signal, and classifies every heartbeat as Normal or LQTS. The network is trained using a dataset of genotype-positive LQTS, and genotype-negative normal ECGs of family relatives. Experimental results reveal a high accuracy in diagnosing LQTS non-invasively, with a very low computational complexity, guaranteeing the clinical application of the proposed method.

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Literatur
1.
Zurück zum Zitat Bazett, H.: An analysis of the time-relations of electrocardiograms. Ann. Noninvasive Electrocardiol. 2(2), 177–194 (1997)CrossRef Bazett, H.: An analysis of the time-relations of electrocardiograms. Ann. Noninvasive Electrocardiol. 2(2), 177–194 (1997)CrossRef
3.
Zurück zum Zitat Hajimolahoseini, H., Hashemi, J., Redfearn, D.: ECG delineation for QT interval analysis using an unsupervised learning method. In: IEEE International Conference on Acoustic, Speech and Signal Processing (2018) Hajimolahoseini, H., Hashemi, J., Redfearn, D.: ECG delineation for QT interval analysis using an unsupervised learning method. In: IEEE International Conference on Acoustic, Speech and Signal Processing (2018)
4.
Zurück zum Zitat Hughes, N.P., Tarassenko, L., Roberts, S.J.: Markov models for automated ECG interval analysis. In: Advances in Neural Information Processing Systems, pp. 611–618 (2004) Hughes, N.P., Tarassenko, L., Roberts, S.J.: Markov models for automated ECG interval analysis. In: Advances in Neural Information Processing Systems, pp. 611–618 (2004)
5.
Zurück zum Zitat Immanuel, S., et al.: T-wave morphology can distinguish healthy controls from LQTS patients. Physiol. Meas. 37(9), 1456 (2016)CrossRef Immanuel, S., et al.: T-wave morphology can distinguish healthy controls from LQTS patients. Physiol. Meas. 37(9), 1456 (2016)CrossRef
6.
Zurück zum Zitat Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift. arXiv preprint arXiv:1502.03167 (2015) Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift. arXiv preprint arXiv:​1502.​03167 (2015)
7.
Zurück zum Zitat İşcan, M., Yilmaz, A., Yilmaz, C.: A novel algorithm combining continuous wavelet transform and philips method for QT interval analysis. In: 2016 National Conference on Electrical, Electronics and Biomedical Engineering (ELECO), pp. 507–511. IEEE (2016) İşcan, M., Yilmaz, A., Yilmaz, C.: A novel algorithm combining continuous wavelet transform and philips method for QT interval analysis. In: 2016 National Conference on Electrical, Electronics and Biomedical Engineering (ELECO), pp. 507–511. IEEE (2016)
9.
Zurück zum Zitat Maršánová, L., et al.: ECG features and methods for automatic classification of ventricular premature and ischemic heartbeats: a comprehensive experimental study. Sci. Rep. 7(1), 11239 (2017)CrossRef Maršánová, L., et al.: ECG features and methods for automatic classification of ventricular premature and ischemic heartbeats: a comprehensive experimental study. Sci. Rep. 7(1), 11239 (2017)CrossRef
10.
Zurück zum Zitat Page, A., Aktas, M.K., Soyata, T., Zareba, W., Couderc, J.P.: “QT clock” to improve detection of QT prolongation in Long QT Syndrome patients. Heart Rhythm 13(1), 190–198 (2016)CrossRef Page, A., Aktas, M.K., Soyata, T., Zareba, W., Couderc, J.P.: “QT clock” to improve detection of QT prolongation in Long QT Syndrome patients. Heart Rhythm 13(1), 190–198 (2016)CrossRef
11.
Zurück zum Zitat Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)MathSciNetMATH Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)MathSciNetMATH
12.
Zurück zum Zitat Struijk, J.J., et al.: Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology. Med. Biol. Eng. Comput. 44(7), 543–549 (2006)CrossRef Struijk, J.J., et al.: Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology. Med. Biol. Eng. Comput. 44(7), 543–549 (2006)CrossRef
13.
Zurück zum Zitat Warrick, P., Homsi, M.N.: Cardiac arrhythmia detection from ECG combining convolutional and long short-term memory networks. In: 2017 Computing in Cardiology (CinC), pp. 1–4. IEEE (2017) Warrick, P., Homsi, M.N.: Cardiac arrhythmia detection from ECG combining convolutional and long short-term memory networks. In: 2017 Computing in Cardiology (CinC), pp. 1–4. IEEE (2017)
Metadaten
Titel
A Deep Learning Approach for Diagnosing Long QT Syndrome Without Measuring QT Interval
verfasst von
Habib Hajimolahoseini
Damian Redfearn
Andrew Krahn
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-18305-9_42