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Erschienen in:
2015 | OriginalPaper | Buchkapitel
Advancement in Gemcitabine Delivery for Cancer Treatment
verfasst von : Uyen Minh Le
Erschienen in: 5th International Conference on Biomedical Engineering in Vietnam
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Gemcitabine is utilized as the first-line treatment for adenocarcinoma of the pancreas that has been considered as one of the most challenging diseases. The major drawback of the gemcitabine formulations is its high hydrophilicity and short half-life. To compensate for those shortcomings, a large dose of infused gemcitabine is usually used to achieve the desire therapeutic effects. However, using this dose, could lead to a high toxicity and severe adverse effects. Hence, there has been a great of interest in the development of gemcitabine to increase the hydrophobicity, half-life, and stability of the drug. In this review, we summarize the latest approaches in drug delivery of gemcitabine to clarify the unsolved problems of drug resistance and discuss the effectiveness of the advanced delivery systems on different types of cancer.