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Journal of Materials Science
Erschienen in: Journal of Materials Science 16/2017

01.05.2017 | Chemical routes to materials

Amphiphilic polymer–drug conjugates based on acid-sensitive 100% hyperbranched polyacetals for cancer therapy

verfasst von: Xiao Duan, Yalan Wu, Mengsi Ma, Junjie Du, Shan Zhang, Heng Chen, Jie Kong

Erschienen in: Journal of Materials Science | Ausgabe 16/2017

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Abstract

A new type of acid-sensitive 100% hyperbranched polyacetals (HBPA) was synthesized, which could be completely degraded into small molecules under acidic environment and avoid the accumulative toxicity in vivo. The AB2 monomer was synthesized by 4-carboxybenzaldehyde and 2-bromoethanol. The bulk polycondensation was carried out in vacuum environment to remove water byproduct. The massive terminal aldehyde groups of HBPA were conjugated with mPEG-NH2 and doxorubicins to form amphiphilic acid-sensitive polymer–drug conjugates (DOX-HBPA-PEG). The stability of the micelles of DOX-HBPA-PEG was evaluated by DLS at different pH value in phosphate buffer saline (PBS). The DOX release in vitro showed that the cumulative release rate was 14.51% in pH 7.4 PBS after 24 h and the cumulative release rate was 48.56% in pH 6.0 PBS after 24 h. The results of cell viability of DOX-HBPA-PEG and HBPA-PEG showed that the polymer–DOX conjugates were effective drug delivery systems. The uptake process of DOX-HBPA-PEG by A549 cells showed that the micelle was totally swallowed in 1 h later. The controllable drug release nature, stability, biocompatibility and completely degradable structures (acid-sensitive) make them to be promising drug delivery systems.
Vorheriger Artikel Near-infrared-emitting colloidal Ag2S quantum dots excited by an 808 nm diode laser
Nächster Artikel Preparation and gas-sensing properties of SnO2/graphene quantum dots composites via solvothermal method

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Metadaten
Titel
Amphiphilic polymer–drug conjugates based on acid-sensitive 100% hyperbranched polyacetals for cancer therapy
verfasst von
Xiao Duan
Yalan Wu
Mengsi Ma
Junjie Du
Shan Zhang
Heng Chen
Jie Kong
Publikationsdatum
01.05.2017
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 16/2017
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-017-1135-1

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