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2016 | OriginalPaper | Buchkapitel

An Online Platform for the Automatic Reporting of Multi-parametric Tissue Signatures: A Case Study in Glioblastoma

verfasst von : Javier Juan-Albarracín, Elies Fuster-Garcia, Juan M. García-Gómez

Erschienen in: Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries

Verlag: Springer International Publishing

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Abstract

Glioblastomas are infiltrative and deeply invasive neoplasms characterized by high vascular proliferation and diffuse margins. As a consequence, this lesion presents a high degree of heterogeneity that requires being studied through a multiparametric combination of several imaging sequences. Nowadays few systems are available to perform a relevant multiparametric analysis of this tumour. In this work, we present the study of GBM by means of http://​mtsimaging.​com, an online platform for the automatic reporting of multiparametric tissue signatures. The platform implements two full automated GBM pipelines: (1) the anatomical pipeline, which involves MRI preprocessing and tumour segmentation; and (2) the hemodynamic MTS pipeline, which adds the quantification of perfusion parameters and a nosologic segmentation map of the vascular habitats of the GBM. A radiologic report summarizes the findings of both analysis and provides volumetric and perfusion statistics of each tissue and habitat of the tumour.

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Literatur
1.
Zurück zum Zitat Soeda, A., Hara, A., Kunisada, T., Yoshimura, S., Iwama, T., Park, D.M.: The evidence of glioblastoma heterogeneity. Nat. Sci. Rep. 5(7979), 1–7 (2015) Soeda, A., Hara, A., Kunisada, T., Yoshimura, S., Iwama, T., Park, D.M.: The evidence of glioblastoma heterogeneity. Nat. Sci. Rep. 5(7979), 1–7 (2015)
2.
Zurück zum Zitat von Deimling, A.: Gliomas. Recent Results in Cancer Research, vol. 171. Springer, Heidelberg (2009)CrossRef von Deimling, A.: Gliomas. Recent Results in Cancer Research, vol. 171. Springer, Heidelberg (2009)CrossRef
3.
Zurück zum Zitat Fuster-Garcia, E., García-Gómez, J.M., De Angelis, E., Sraum, A., Molnar, A., Van Huffel, S., Stamatakos, G.: Use case II: imaging biomarkers and new trends for integrated glioblastoma management. In: Martí-Bonmatí, L., Alberich-Bayarri, A. (eds.) Imaging Biomarkers, pp. 181–194. Springer, Heidelberg (2017)CrossRef Fuster-Garcia, E., García-Gómez, J.M., De Angelis, E., Sraum, A., Molnar, A., Van Huffel, S., Stamatakos, G.: Use case II: imaging biomarkers and new trends for integrated glioblastoma management. In: Martí-Bonmatí, L., Alberich-Bayarri, A. (eds.) Imaging Biomarkers, pp. 181–194. Springer, Heidelberg (2017)CrossRef
4.
Zurück zum Zitat Knopp, E.A., Cha, S., Johnson, G., Mazumdar, A., Golfinos, J.G., Zagzag, D., Miller, D.C., Kelly, P.J., Kricheff, I.I.: Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 211(3), 791–798 (1999)CrossRef Knopp, E.A., Cha, S., Johnson, G., Mazumdar, A., Golfinos, J.G., Zagzag, D., Miller, D.C., Kelly, P.J., Kricheff, I.I.: Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology 211(3), 791–798 (1999)CrossRef
5.
Zurück zum Zitat Shah, M.K., Shin, W., Parikh, V.S., Ragin, A., Mouannes, J., Bernstein, R.A., Walker, M.T., Bhatt, H., Carroll, T.J.: Quantitative cerebral MR perfusion imaging: preliminary results in stroke. J. Magn. Reson. Imaging 32(4), 796–802 (2010)CrossRef Shah, M.K., Shin, W., Parikh, V.S., Ragin, A., Mouannes, J., Bernstein, R.A., Walker, M.T., Bhatt, H., Carroll, T.J.: Quantitative cerebral MR perfusion imaging: preliminary results in stroke. J. Magn. Reson. Imaging 32(4), 796–802 (2010)CrossRef
6.
Zurück zum Zitat Menze, B.H., Jakab, A., Bauer, S., Kalpathy-Cramer, J., Farahani, K., Kirby, J., Burren, Y., Porz, N., Slotboom, J., Wiest, R., Lanczi, L.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2015)CrossRef Menze, B.H., Jakab, A., Bauer, S., Kalpathy-Cramer, J., Farahani, K., Kirby, J., Burren, Y., Porz, N., Slotboom, J., Wiest, R., Lanczi, L.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2015)CrossRef
7.
Zurück zum Zitat Juan-Albarracín, J., Fuster-Garcia, E., Robles, M., Manjón-Herrera, J.V., Sáez-Silvestre, C., Esparza-Manzano, M., García-Gómez, J.M.: Patent ESP201431289: Método y sistema de generación de imágenesnosológicas multiparamétricas, 19 October 2015 Juan-Albarracín, J., Fuster-Garcia, E., Robles, M., Manjón-Herrera, J.V., Sáez-Silvestre, C., Esparza-Manzano, M., García-Gómez, J.M.: Patent ESP201431289: Método y sistema de generación de imágenesnosológicas multiparamétricas, 19 October 2015
8.
Zurück zum Zitat Manjón, J.V., Coupé, P., Martí-Bonmatí, L., Collins, D.L., Robles, M.: Adaptive non-local means denoising of MR images with spatially varying noise levels. J. Magn. Reson. Imaging 31(1), 192–203 (2010)CrossRef Manjón, J.V., Coupé, P., Martí-Bonmatí, L., Collins, D.L., Robles, M.: Adaptive non-local means denoising of MR images with spatially varying noise levels. J. Magn. Reson. Imaging 31(1), 192–203 (2010)CrossRef
9.
Zurück zum Zitat Tustison, N.J., Avants, B.B., Cook, P.A., Zheng, Y., Egan, A., Yushkevich, P.A., Gee, J.C.: N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29(6), 1310–1320 (2010)CrossRef Tustison, N.J., Avants, B.B., Cook, P.A., Zheng, Y., Egan, A., Yushkevich, P.A., Gee, J.C.: N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29(6), 1310–1320 (2010)CrossRef
10.
Zurück zum Zitat Avants, B.B., Epstein, C.L., Grossman, M., Gee, J.C.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008)CrossRef Avants, B.B., Epstein, C.L., Grossman, M., Gee, J.C.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008)CrossRef
11.
Zurück zum Zitat Juan-Albarracín, J., Fuster-Garcia, E., Manjón, J.V., Robles, M., Aparici, F., Martí-Bonmatí, L., García-Gómez, J.M.: Automated glioblastoma segmentation based on a multiparametric structured unsupervised classification. PLOS One 10(5), 1–20 (2015)CrossRef Juan-Albarracín, J., Fuster-Garcia, E., Manjón, J.V., Robles, M., Aparici, F., Martí-Bonmatí, L., García-Gómez, J.M.: Automated glioblastoma segmentation based on a multiparametric structured unsupervised classification. PLOS One 10(5), 1–20 (2015)CrossRef
12.
Zurück zum Zitat Juan-Albarracín, J., Fuster-Garcia, E., García-Gómez, J.M.: Glioblastoma tissue-guided segmentation through unsupervisedstructured classification. In: Proceedings of II International Symposium onClinical and Basic Investigation in Glioblastoma, vol. 1, no. 3, p. 101 (2015) Juan-Albarracín, J., Fuster-Garcia, E., García-Gómez, J.M.: Glioblastoma tissue-guided segmentation through unsupervisedstructured classification. In: Proceedings of II International Symposium onClinical and Basic Investigation in Glioblastoma, vol. 1, no. 3, p. 101 (2015)
13.
Zurück zum Zitat Nikou, C., Galatsanos, N.P., Likas, C.L.: A class-adaptive spatially variant mixture model for image segmentation. IEEE Trans. Image Process. 16(4), 1121–1130 (2007)MathSciNetCrossRef Nikou, C., Galatsanos, N.P., Likas, C.L.: A class-adaptive spatially variant mixture model for image segmentation. IEEE Trans. Image Process. 16(4), 1121–1130 (2007)MathSciNetCrossRef
14.
Zurück zum Zitat Boxerman, J.L., Schmainda, K.M., Weisskoff, R.M.: Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. Am. J. Neuroradiol. 27(4), 859–867 (2006) Boxerman, J.L., Schmainda, K.M., Weisskoff, R.M.: Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. Am. J. Neuroradiol. 27(4), 859–867 (2006)
15.
Zurück zum Zitat Tofts, P.S.: Quantitative MRI of the Brain: Measuring Changes Caused by Disease, vol. 1. Wiley, England (2005). West Sussex PO19 8SQ Tofts, P.S.: Quantitative MRI of the Brain: Measuring Changes Caused by Disease, vol. 1. Wiley, England (2005). West Sussex PO19 8SQ
16.
Zurück zum Zitat Quarles, C.C., Gore, J.C., Xu, L., Yankeelov, T.E.: Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters. Magn. Reson. Imaging 30(7), 944–953 (2012)CrossRef Quarles, C.C., Gore, J.C., Xu, L., Yankeelov, T.E.: Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters. Magn. Reson. Imaging 30(7), 944–953 (2012)CrossRef
Metadaten
Titel
An Online Platform for the Automatic Reporting of Multi-parametric Tissue Signatures: A Case Study in Glioblastoma
verfasst von
Javier Juan-Albarracín
Elies Fuster-Garcia
Juan M. García-Gómez
Copyright-Jahr
2016
DOI
https://doi.org/10.1007/978-3-319-55524-9_5

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