Skip to main content
Erschienen in:
Buchtitelbild

2014 | OriginalPaper | Buchkapitel

Big Complex Biomedical Data: Towards a Taxonomy of Data

verfasst von : Andreas Holzinger, Christof Stocker, Matthias Dehmer

Erschienen in: E-Business and Telecommunications

Verlag: Springer Berlin Heidelberg

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Professionals in the Life Sciences are faced with increasing masses of complex data sets. Very few data is structured, where traditional information retrieval methods work perfectly. A large portion of data is weakly structured; however, the majority falls into the category of unstructured data. To discover previously unknown knowledge from this data, we need advanced and novel methods to deal with the data from two aspects: time (e.g. information entropy) and space (e.g. computational topology). In this paper we show some examples of biomedical data and discuss a taxonomy of data with the specifics on medical data sets.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Bell, G., Hey, T., Szalay, A.: Beyond the data deluge. Science 323(5919), 1297–1298 (2009)CrossRef Bell, G., Hey, T., Szalay, A.: Beyond the data deluge. Science 323(5919), 1297–1298 (2009)CrossRef
2.
Zurück zum Zitat Hey, T., Tansley, S., Tolle, K.: The Fourth Paradigm: Data-Intensive Scientific Discovery. Microsoft Research, Redmond (2009) Hey, T., Tansley, S., Tolle, K.: The Fourth Paradigm: Data-Intensive Scientific Discovery. Microsoft Research, Redmond (2009)
3.
Zurück zum Zitat Holzinger, A.: Weakly structured data in health-informatics: the challenge for human-computer interaction (2011) Holzinger, A.: Weakly structured data in health-informatics: the challenge for human-computer interaction (2011)
4.
Zurück zum Zitat Patel, V.L., Kahol, K., Buchman, T.: Biomedical complexity and error. J. Biomed. Inform. 44(3), 387–389 (2011)CrossRef Patel, V.L., Kahol, K., Buchman, T.: Biomedical complexity and error. J. Biomed. Inform. 44(3), 387–389 (2011)CrossRef
5.
Zurück zum Zitat Holzinger, A.: Biomedical Informatics: Discovering Knowledge in Big Data. Springer, New York (2014)CrossRef Holzinger, A.: Biomedical Informatics: Discovering Knowledge in Big Data. Springer, New York (2014)CrossRef
6.
Zurück zum Zitat Holzinger, A., Jurisica, I.: Knowledge discovery and data mining in biomedical informatics: the future is in integrative, interactive machine learning solutions. In: Holzinger, A., Jurisica, I. (eds.) Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. LNCS, vol. 8401, pp. 1–18. Springer, Heidelberg (2014) CrossRef Holzinger, A., Jurisica, I.: Knowledge discovery and data mining in biomedical informatics: the future is in integrative, interactive machine learning solutions. In: Holzinger, A., Jurisica, I. (eds.) Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. LNCS, vol. 8401, pp. 1–18. Springer, Heidelberg (2014) CrossRef
7.
Zurück zum Zitat Holzinger, A., Geierhofer, R., Modritscher, F., Tatzl, R.: Semantic information in medical information systems: utilization of text mining techniques to analyze medical diagnoses. J. Univ. Comput. Sci. 14(22), 3781–3795 (2008) Holzinger, A., Geierhofer, R., Modritscher, F., Tatzl, R.: Semantic information in medical information systems: utilization of text mining techniques to analyze medical diagnoses. J. Univ. Comput. Sci. 14(22), 3781–3795 (2008)
8.
Zurück zum Zitat Gregory, J., Mattison, J.E., Linde, C.: Naming notes - transitions from free-text to structured entry. Meth. Inf. Med. 34(1–2), 57–67 (1995) Gregory, J., Mattison, J.E., Linde, C.: Naming notes - transitions from free-text to structured entry. Meth. Inf. Med. 34(1–2), 57–67 (1995)
9.
Zurück zum Zitat Holzinger, A., Kainz, A., Gell, G., Brunold, M., Maurer, H.: Interactive computer assisted formulation of retrieval requests for a medical information system using an intelligent tutoring system. World Conference on Educational Multimedia, Hypermedia and Telecommunications ED-MEDIA 2000, pp. 431–436. AACE, Charlottesville (2000) Holzinger, A., Kainz, A., Gell, G., Brunold, M., Maurer, H.: Interactive computer assisted formulation of retrieval requests for a medical information system using an intelligent tutoring system. World Conference on Educational Multimedia, Hypermedia and Telecommunications ED-MEDIA 2000, pp. 431–436. AACE, Charlottesville (2000)
10.
Zurück zum Zitat Lovis, C., Baud, R.H., Planche, P.: Power of expression in the electronic patient record: structured data or narrative text? Int. J. Med. Inf. 58, 101–110 (2000)CrossRef Lovis, C., Baud, R.H., Planche, P.: Power of expression in the electronic patient record: structured data or narrative text? Int. J. Med. Inf. 58, 101–110 (2000)CrossRef
11.
Zurück zum Zitat Pascucci, V., Tricoche, X., Hagen, H., Tierny, J.: Topological Methods in Data Analysis and Visualization: Theory, Algorithms, and Applications. Springer, Heidelberg (2011)CrossRef Pascucci, V., Tricoche, X., Hagen, H., Tierny, J.: Topological Methods in Data Analysis and Visualization: Theory, Algorithms, and Applications. Springer, Heidelberg (2011)CrossRef
12.
Zurück zum Zitat Blandford, A., Attfield, S.: Interacting with information. Synth. Lect. Hum. Centered Inf. 3(1), 1–99 (2010)CrossRef Blandford, A., Attfield, S.: Interacting with information. Synth. Lect. Hum. Centered Inf. 3(1), 1–99 (2010)CrossRef
13.
Zurück zum Zitat Kaski, S., Peltonen, J.: Dimensionality reduction for data visualization (applications corner). IEEE Signal Process. Mag. 28(2), 100–104 (2011)CrossRef Kaski, S., Peltonen, J.: Dimensionality reduction for data visualization (applications corner). IEEE Signal Process. Mag. 28(2), 100–104 (2011)CrossRef
14.
Zurück zum Zitat Holzinger, A., Hörtenhuber, M., Mayer, C., Bachler, M., Wassertheurer, S., Pinho, A.J., Koslicki, D.: On entropy-based data mining. In: Holzinger, A., Jurisica, I. (eds.) Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. LNCS, vol. 8401, pp. 209–226. Springer, Heidelberg (2014) CrossRef Holzinger, A., Hörtenhuber, M., Mayer, C., Bachler, M., Wassertheurer, S., Pinho, A.J., Koslicki, D.: On entropy-based data mining. In: Holzinger, A., Jurisica, I. (eds.) Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. LNCS, vol. 8401, pp. 209–226. Springer, Heidelberg (2014) CrossRef
15.
Zurück zum Zitat Beale, R.: Supporting serendipity: using ambient intelligence to augment user exploration for data mining and web browsing. Int. J. Hum. Comput. Stud. 65(5), 421–433 (2007)CrossRef Beale, R.: Supporting serendipity: using ambient intelligence to augment user exploration for data mining and web browsing. Int. J. Hum. Comput. Stud. 65(5), 421–433 (2007)CrossRef
16.
Zurück zum Zitat Yau, N.: Seeing the World in Data, pp. 246–248. Princeton Architectural Press, New York (2011) Yau, N.: Seeing the World in Data, pp. 246–248. Princeton Architectural Press, New York (2011)
17.
Zurück zum Zitat Pržulj, N., Higham, D.J.: Modelling protein-protein interaction networks via a stickiness index. J. Roy. Soc. Interface 3(10), 711–716 (2006)CrossRef Pržulj, N., Higham, D.J.: Modelling protein-protein interaction networks via a stickiness index. J. Roy. Soc. Interface 3(10), 711–716 (2006)CrossRef
18.
Zurück zum Zitat Emmert-Streib, F., Dehmer, M. (eds.): Analysis of Microarray Data: A Network-Based Approach. Wiley VCH Publishing, Chichester (2010) Emmert-Streib, F., Dehmer, M. (eds.): Analysis of Microarray Data: A Network-Based Approach. Wiley VCH Publishing, Chichester (2010)
19.
Zurück zum Zitat Shi, L., Lei, X., Zhang, A.: Protein complex detection with semi-supervised learning in protein interaction networks. Proteome Sci. 9(Suppl. 1), S5 (2011)CrossRef Shi, L., Lei, X., Zhang, A.: Protein complex detection with semi-supervised learning in protein interaction networks. Proteome Sci. 9(Suppl. 1), S5 (2011)CrossRef
20.
Zurück zum Zitat Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksz, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H., Wanker, E.E.: A human protein-protein interaction network: a resource for annotating the proteome. Cell 122(6), 957–968 (2005)CrossRef Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F.H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksz, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H., Wanker, E.E.: A human protein-protein interaction network: a resource for annotating the proteome. Cell 122(6), 957–968 (2005)CrossRef
21.
Zurück zum Zitat Zhang, A.: Protein Interaction Networks: Computational Analysis. Cambridge University Press, Cambridge (2009)CrossRef Zhang, A.: Protein Interaction Networks: Computational Analysis. Cambridge University Press, Cambridge (2009)CrossRef
22.
Zurück zum Zitat Arrais, J.P., Lopes, P., Oliveira, J.L.: Challenges storing and representing biomedical data. In: Holzinger, A., Simonic, K.-M. (eds.) USAB 2011. LNCS, vol. 7058, pp. 53–62. Springer, Heidelberg (2011) CrossRef Arrais, J.P., Lopes, P., Oliveira, J.L.: Challenges storing and representing biomedical data. In: Holzinger, A., Simonic, K.-M. (eds.) USAB 2011. LNCS, vol. 7058, pp. 53–62. Springer, Heidelberg (2011) CrossRef
23.
Zurück zum Zitat Wiltgen, M., Holzinger, A.: Visualization in Bioinformatics: Protein Structures with Physicochemical and Biological Annotations, pp. 69–74. Czech Technical University (CTU), Prague (2005) Wiltgen, M., Holzinger, A.: Visualization in Bioinformatics: Protein Structures with Physicochemical and Biological Annotations, pp. 69–74. Czech Technical University (CTU), Prague (2005)
24.
Zurück zum Zitat Wiltgen, M., Holzinger, A., Tilz, G.P.: Interactive analysis and visualization of macromolecular interfaces between proteins. In: Holzinger, A. (ed.) USAB 2007. LNCS, vol. 4799, pp. 199–212. Springer, Heidelberg (2007) CrossRef Wiltgen, M., Holzinger, A., Tilz, G.P.: Interactive analysis and visualization of macromolecular interfaces between proteins. In: Holzinger, A. (ed.) USAB 2007. LNCS, vol. 4799, pp. 199–212. Springer, Heidelberg (2007) CrossRef
25.
Zurück zum Zitat Barabási, A.L., Albert, R., Jeong, H.: Mean-field theory for scale-free random networks. Physica A: Stat. Mech. Appl. 272(1–2), 173–187 (1999)CrossRef Barabási, A.L., Albert, R., Jeong, H.: Mean-field theory for scale-free random networks. Physica A: Stat. Mech. Appl. 272(1–2), 173–187 (1999)CrossRef
27.
Zurück zum Zitat Costa, L., Rodrigues, F., Cristino, A.: Complex networks: the key to systems biology. Genet. Mol. Biol. 31(3), 591–601 (2008)CrossRef Costa, L., Rodrigues, F., Cristino, A.: Complex networks: the key to systems biology. Genet. Mol. Biol. 31(3), 591–601 (2008)CrossRef
28.
Zurück zum Zitat Dastani, M.: The role of visual perception in data visualization. J. Vis. Lang. Comput. 13, 601–622 (2002)CrossRef Dastani, M.: The role of visual perception in data visualization. J. Vis. Lang. Comput. 13, 601–622 (2002)CrossRef
29.
Zurück zum Zitat Egenhofer, M.: Reasoning about binary topological relations. In: Günther, O., Schek, H.-J. (eds.) SSD 1991. LNCS, vol. 525, pp. 141–160. Springer, Heidelberg (1991) CrossRef Egenhofer, M.: Reasoning about binary topological relations. In: Günther, O., Schek, H.-J. (eds.) SSD 1991. LNCS, vol. 525, pp. 141–160. Springer, Heidelberg (1991) CrossRef
30.
Zurück zum Zitat Egenhofer, M., Herring, J.: Categorizing binary topological relations between regions, lines, and points in geographic databases. Technical Report, Department of Surveying Engineering, University of Maine (1990) Egenhofer, M., Herring, J.: Categorizing binary topological relations between regions, lines, and points in geographic databases. Technical Report, Department of Surveying Engineering, University of Maine (1990)
31.
Zurück zum Zitat Aleksandrov, P.: Elementary Concepts of Topology. Dover Publications, New York (1961) Aleksandrov, P.: Elementary Concepts of Topology. Dover Publications, New York (1961)
32.
Zurück zum Zitat Egenhofer, M., Franzosa, R.: On the equivalence of topological relations. Int. J. Geogr. Inf. Syst. 9(2), 133–152 (1995)CrossRef Egenhofer, M., Franzosa, R.: On the equivalence of topological relations. Int. J. Geogr. Inf. Syst. 9(2), 133–152 (1995)CrossRef
33.
Zurück zum Zitat Stuckenschmidt, H., van Harmelen, F.: Information Sharing on the Semantic Web. Advanced Information and Knowledge Processing. Springer, Heidelberg (2005)CrossRefMATH Stuckenschmidt, H., van Harmelen, F.: Information Sharing on the Semantic Web. Advanced Information and Knowledge Processing. Springer, Heidelberg (2005)CrossRefMATH
34.
Zurück zum Zitat Kapovich, I., Myasnikov, A., Schupp, P., Shpilrain, V.: Generic-case complexity, decision problems in group theory, and random walks. J. Algebra 264(2), 665–694 (2003)MathSciNetCrossRefMATH Kapovich, I., Myasnikov, A., Schupp, P., Shpilrain, V.: Generic-case complexity, decision problems in group theory, and random walks. J. Algebra 264(2), 665–694 (2003)MathSciNetCrossRefMATH
35.
Zurück zum Zitat de Silva, V., Carlsson, G.: Topological estimation using witness complexes. In: Proceedings of Eurographics Symposium on Point-Based Graphics, pp. 157–166 (2004) de Silva, V., Carlsson, G.: Topological estimation using witness complexes. In: Proceedings of Eurographics Symposium on Point-Based Graphics, pp. 157–166 (2004)
36.
Zurück zum Zitat Simon, H.A.: The structure of ill structured problems. Artif. Intell. 4(3–4), 181–201 (1973)CrossRef Simon, H.A.: The structure of ill structured problems. Artif. Intell. 4(3–4), 181–201 (1973)CrossRef
37.
Zurück zum Zitat Duda, R.O., Hart, P.E., Stork, D.G.: Pattern Classification, 2nd edn. Wiley, New York (2000) Duda, R.O., Hart, P.E., Stork, D.G.: Pattern Classification, 2nd edn. Wiley, New York (2000)
38.
Zurück zum Zitat Kreuzthaler, M., Bloice, M., Faulstich, L., Simonic, K., Holzinger, A.: A comparison of different retrieval strategies working on medical free texts. J. Univ. Comput. Sci. 17(7), 1109–1133 (2011) Kreuzthaler, M., Bloice, M., Faulstich, L., Simonic, K., Holzinger, A.: A comparison of different retrieval strategies working on medical free texts. J. Univ. Comput. Sci. 17(7), 1109–1133 (2011)
39.
Zurück zum Zitat Ahmadian, L., van Engen-Verheul, M., Bakhshi-Raiez, F., Peek, N., Cornet, R., de Keizer, N.F.: The role of standardized data and terminological systems in computerized clinical decision support systems: Literature review and survey. Int. J. Med. Inf. 80(2), 81–93 (2011)CrossRef Ahmadian, L., van Engen-Verheul, M., Bakhshi-Raiez, F., Peek, N., Cornet, R., de Keizer, N.F.: The role of standardized data and terminological systems in computerized clinical decision support systems: Literature review and survey. Int. J. Med. Inf. 80(2), 81–93 (2011)CrossRef
40.
Zurück zum Zitat Batini, C., Scannapieco, M.: Data Quality: Concepts, Methodologies and Techniques. Springer, Heidelberg (2006) Batini, C., Scannapieco, M.: Data Quality: Concepts, Methodologies and Techniques. Springer, Heidelberg (2006)
41.
Zurück zum Zitat Richman, J.S.: Multivariate Neighborhood Sample Entropy: A Method for Data Reduction and Prediction of Complex Data, pp. 297–408. Elsevier, Amsterdam (2011) Richman, J.S.: Multivariate Neighborhood Sample Entropy: A Method for Data Reduction and Prediction of Complex Data, pp. 297–408. Elsevier, Amsterdam (2011)
42.
Zurück zum Zitat Komaroff, A.L.: The variability and inaccuracy of medical data. Proc. IEEE 67(9), 1196–1207 (1979)CrossRef Komaroff, A.L.: The variability and inaccuracy of medical data. Proc. IEEE 67(9), 1196–1207 (1979)CrossRef
43.
Zurück zum Zitat Walsh, J.E.: Analyzing medical data: some statistical considerations. IRE Trans. Med. Electron. ME–7(4), 362–366 (1960)CrossRef Walsh, J.E.: Analyzing medical data: some statistical considerations. IRE Trans. Med. Electron. ME–7(4), 362–366 (1960)CrossRef
44.
Zurück zum Zitat Miller, R., McNeil, M., Challinor, S., Masarie Jr, F., Myers, J.: The internist-1/quick medical reference project-status report. West. J. Med. 145(6), 816 (1986) Miller, R., McNeil, M., Challinor, S., Masarie Jr, F., Myers, J.: The internist-1/quick medical reference project-status report. West. J. Med. 145(6), 816 (1986)
45.
Zurück zum Zitat Davenport, T., Glaser, J.: Just-in-time delivery comes to knowledge management. Harvard Bus. Rev. 80(7), 107–111 (2002) Davenport, T., Glaser, J.: Just-in-time delivery comes to knowledge management. Harvard Bus. Rev. 80(7), 107–111 (2002)
46.
Zurück zum Zitat Manyika, J., Chui, M., Brown, B., Bughin, J., Dobbs, R., Roxburgh, C., Byers, A.H.: Big Data: The Next Frontier for Innovation, Competition, and Productivity. McKinsey Global Institute, Washington (DC) (2011) Manyika, J., Chui, M., Brown, B., Bughin, J., Dobbs, R., Roxburgh, C., Byers, A.H.: Big Data: The Next Frontier for Innovation, Competition, and Productivity. McKinsey Global Institute, Washington (DC) (2011)
47.
Zurück zum Zitat Card, S.K., Mackinlay, J.D., Shneiderman, B.: Information Visualization: Using Vision to Think, pp. 1–34. Morgan Kaufmann, San Francisco (1999). Card, S.K., Mackinlay, J.D., Shneiderman, B.: Information Visualization: Using Vision to Think, pp. 1–34. Morgan Kaufmann, San Francisco (1999).
48.
Zurück zum Zitat Inselberg, A.: Parallel Coordinates: Visual Multidimensional Geometry and Its Applications (foreword by Ben Shneiderman). Springer, Heidelberg (2009)CrossRef Inselberg, A.: Parallel Coordinates: Visual Multidimensional Geometry and Its Applications (foreword by Ben Shneiderman). Springer, Heidelberg (2009)CrossRef
49.
Zurück zum Zitat Novakova, L., Stepankova, O.: Radviz and identification of clusters in multidimensional data. In: 13th International Conference on Information Visualisation, pp. 104–109 (2009) Novakova, L., Stepankova, O.: Radviz and identification of clusters in multidimensional data. In: 13th International Conference on Information Visualisation, pp. 104–109 (2009)
50.
Zurück zum Zitat Meyer-Spradow, J., Stegger, L., Doering, C., Ropinski, T., Hinirchs, K.: Glyph-based spect visualization for the diagnosis of coronary artery disease. IEEE Trans. Visual Comput. Graphics 14(6), 1499–1506 (2008)CrossRef Meyer-Spradow, J., Stegger, L., Doering, C., Ropinski, T., Hinirchs, K.: Glyph-based spect visualization for the diagnosis of coronary artery disease. IEEE Trans. Visual Comput. Graphics 14(6), 1499–1506 (2008)CrossRef
51.
Zurück zum Zitat Fox, P., Hendler, J.: Changing the equation on scientific data visualization. Science 331(6018), 705–708 (2011)CrossRef Fox, P., Hendler, J.: Changing the equation on scientific data visualization. Science 331(6018), 705–708 (2011)CrossRef
52.
Zurück zum Zitat de Jong, T.: Computer simulations - technological advances in inquiry learning. Science 312(5773), 532–533 (2006)CrossRef de Jong, T.: Computer simulations - technological advances in inquiry learning. Science 312(5773), 532–533 (2006)CrossRef
53.
Zurück zum Zitat Chittaro, L.: Information visualization and its application to medicine. Artif. Intell. Med. 22(2), 81–88 (2001)CrossRef Chittaro, L.: Information visualization and its application to medicine. Artif. Intell. Med. 22(2), 81–88 (2001)CrossRef
54.
Zurück zum Zitat Johnson, C.R., MacLeod, R., Parker, S.G., Weinstein, D.: Biomedical computing and visualization software environments. Commun. ACM 47(11), 64–71 (2004)CrossRef Johnson, C.R., MacLeod, R., Parker, S.G., Weinstein, D.: Biomedical computing and visualization software environments. Commun. ACM 47(11), 64–71 (2004)CrossRef
55.
Zurück zum Zitat Ebner, M., Holzinger, A.: Successful implementation of user-centered game based learning in higher education an example from civil engineering. Comput. Educ. 49(3), 873–890 (2007)CrossRef Ebner, M., Holzinger, A.: Successful implementation of user-centered game based learning in higher education an example from civil engineering. Comput. Educ. 49(3), 873–890 (2007)CrossRef
56.
Zurück zum Zitat Kickmeier-Rust, M.D., Peirce, N., Conlan, O., Schwarz, D., Verpoorten, D., Albert, D.: Immersive Digital Games: The Interfaces for Next-Generation E-Learning?, pp. 647–656. Springer, Heidelberg (2007) Kickmeier-Rust, M.D., Peirce, N., Conlan, O., Schwarz, D., Verpoorten, D., Albert, D.: Immersive Digital Games: The Interfaces for Next-Generation E-Learning?, pp. 647–656. Springer, Heidelberg (2007)
57.
Zurück zum Zitat Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popovic, Z., Players, F.: Predicting protein structures with a multiplayer online game. Nature 466(7307), 756–760 (2010)CrossRef Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popovic, Z., Players, F.: Predicting protein structures with a multiplayer online game. Nature 466(7307), 756–760 (2010)CrossRef
58.
Zurück zum Zitat Mayer, R.E., Hegarty, M., Mayer, S., Campbell, J.: When static media promote active learning: annotated illustrations versus narrated animations in multimedia instruction. J. Exp. Psychol. Appl. 11(4), 256–265 (2005)CrossRef Mayer, R.E., Hegarty, M., Mayer, S., Campbell, J.: When static media promote active learning: annotated illustrations versus narrated animations in multimedia instruction. J. Exp. Psychol. Appl. 11(4), 256–265 (2005)CrossRef
59.
Zurück zum Zitat Holzinger, A., Kickmeier-Rust, M., Albert, D.: Dynamic media in computer science education; content complexity and learning performance: is less more? Educ. Technol. Soc. 11(1), 279–290 (2008) Holzinger, A., Kickmeier-Rust, M., Albert, D.: Dynamic media in computer science education; content complexity and learning performance: is less more? Educ. Technol. Soc. 11(1), 279–290 (2008)
60.
Zurück zum Zitat Hessinger, M., Holzinger, A., Leitner, D., Wassertheurer, S.: Haemodynamic models for education in physiology. Math. Comput. Simul. Simul. News Eur. 16(2), 64–68 (2006) Hessinger, M., Holzinger, A., Leitner, D., Wassertheurer, S.: Haemodynamic models for education in physiology. Math. Comput. Simul. Simul. News Eur. 16(2), 64–68 (2006)
61.
Zurück zum Zitat McDonald, D.: The relation of pulsatile pressure to flow in arteries. J. Physiol. 127, 533–552 (1955) McDonald, D.: The relation of pulsatile pressure to flow in arteries. J. Physiol. 127, 533–552 (1955)
62.
Zurück zum Zitat Womersley, J.R.: Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known. J. Physiol. 127(3), 553–563 (1955) Womersley, J.R.: Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known. J. Physiol. 127(3), 553–563 (1955)
63.
Zurück zum Zitat Pedley, T.: The Fluid Mechanics of Large Blood Vessels. Cambridge University Press, Cambridge (1980)CrossRefMATH Pedley, T.: The Fluid Mechanics of Large Blood Vessels. Cambridge University Press, Cambridge (1980)CrossRefMATH
64.
Zurück zum Zitat Leitner, D., Wassertheurer, S., Hessinger, M., Holzinger, A.: A lattice boltzmann model for pulsative blood flow in elastic vessels. New Comput. Med. Inf. Health Care 123(4), 64–68 (2006). Special Edition of Springer e&i Leitner, D., Wassertheurer, S., Hessinger, M., Holzinger, A.: A lattice boltzmann model for pulsative blood flow in elastic vessels. New Comput. Med. Inf. Health Care 123(4), 64–68 (2006). Special Edition of Springer e&i
65.
Zurück zum Zitat Holzinger, A., Ebner, M.: Interaction and Usability of Simulations & Animations: A Case Study of the Flash Technology, pp. 777–780. IOS Press, Zurich (2003) Holzinger, A., Ebner, M.: Interaction and Usability of Simulations & Animations: A Case Study of the Flash Technology, pp. 777–780. IOS Press, Zurich (2003)
66.
Zurück zum Zitat Holzinger, A.: Application of rapid prototyping to the user interface development for a virtual medical campus. IEEE Softw. 21(1), 92–99 (2004)CrossRef Holzinger, A.: Application of rapid prototyping to the user interface development for a virtual medical campus. IEEE Softw. 21(1), 92–99 (2004)CrossRef
67.
Zurück zum Zitat Holzinger, A.: Usability engineering for software developers. Commun. ACM 48(1), 71–74 (2005)CrossRef Holzinger, A.: Usability engineering for software developers. Commun. ACM 48(1), 71–74 (2005)CrossRef
68.
Zurück zum Zitat Holzinger, A., Kickmeier-Rust, M.D., Wassertheurer, S., Hessinger, M.: Learning performance with interactive simulations in medical education: lessons learned from results of learning complex physiological models with the haemodynamics simulator. Comput. Educ. 52(2), 292–301 (2009)CrossRef Holzinger, A., Kickmeier-Rust, M.D., Wassertheurer, S., Hessinger, M.: Learning performance with interactive simulations in medical education: lessons learned from results of learning complex physiological models with the haemodynamics simulator. Comput. Educ. 52(2), 292–301 (2009)CrossRef
69.
Zurück zum Zitat Schrödinger, E.: What Is Life? The Physical Aspect of the Living Cell. Dublin Institute for Advanced Studies at Trinity College, Dublin (1944) Schrödinger, E.: What Is Life? The Physical Aspect of the Living Cell. Dublin Institute for Advanced Studies at Trinity College, Dublin (1944)
71.
Zurück zum Zitat Fisher, J., Harel, D., Henzinger, T.: Biology as reactivity. Commun. ACM 54(10), 72–82 (2011)CrossRef Fisher, J., Harel, D., Henzinger, T.: Biology as reactivity. Commun. ACM 54(10), 72–82 (2011)CrossRef
72.
Zurück zum Zitat Vendruscolo, M., Dobson, C.M.: Protein dynamics: moore’s law in molecular biology. Curr. Biol. 21(2), R68–R70 (2011)CrossRef Vendruscolo, M., Dobson, C.M.: Protein dynamics: moore’s law in molecular biology. Curr. Biol. 21(2), R68–R70 (2011)CrossRef
73.
Zurück zum Zitat Holzinger, A.: Process Guide for Students for Interdisciplinary Work in Computer Science/Informatics, 2nd edn. BoD, Norderstedt (2010) Holzinger, A.: Process Guide for Students for Interdisciplinary Work in Computer Science/Informatics, 2nd edn. BoD, Norderstedt (2010)
74.
Zurück zum Zitat Wing, J.M.: Computational thinking and thinking about computing. Philos. Trans. Roy. Soc. A: Math. Phys. Eng. Sci. 366(1881), 3717–3725 (2008)MathSciNetCrossRefMATH Wing, J.M.: Computational thinking and thinking about computing. Philos. Trans. Roy. Soc. A: Math. Phys. Eng. Sci. 366(1881), 3717–3725 (2008)MathSciNetCrossRefMATH
75.
Zurück zum Zitat Holzinger, A., Dehmer, M., Jurisica, I.: Knowledge discovery and interactive data mining in bioinformatics - state-of-the-art, future challenges and research directions. BMC Bioinform. 15(Suppl 6), I1 (2014)CrossRef Holzinger, A., Dehmer, M., Jurisica, I.: Knowledge discovery and interactive data mining in  bioinformatics - state-of-the-art, future challenges and research directions. BMC Bioinform. 15(Suppl 6), I1 (2014)CrossRef
76.
Zurück zum Zitat Simon, H.: Designing Organizations for an Information-Rich World, pp. 37–72. The Johns Hopkins Press, Baltimore (1971) Simon, H.: Designing Organizations for an Information-Rich World, pp. 37–72. The Johns Hopkins Press, Baltimore (1971)
77.
Zurück zum Zitat Holzinger, A.: Human-computer interaction and knowledge discovery (HCI-KDD): what is the benefit of bringing those two fields to work together? In: Cuzzocrea, A., Kittl, C., Simos, D.E., Weippl, E., Xu, L. (eds.) CD-ARES 2013. LNCS, vol. 8127, pp. 319–328. Springer, Heidelberg (2013) CrossRef Holzinger, A.: Human-computer interaction and knowledge discovery (HCI-KDD): what is the benefit of bringing those two fields to work together? In: Cuzzocrea, A., Kittl, C., Simos, D.E., Weippl, E., Xu, L. (eds.) CD-ARES 2013. LNCS, vol. 8127, pp. 319–328. Springer, Heidelberg (2013) CrossRef
Metadaten
Titel
Big Complex Biomedical Data: Towards a Taxonomy of Data
verfasst von
Andreas Holzinger
Christof Stocker
Matthias Dehmer
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-44791-8_1

Premium Partner