nach oben

Erschienen in:

2013 | OriginalPaper | Buchkapitel

Biodegradable Polymers for Potential Delivery Systems for Therapeutics

verfasst von : Sanjeev K. Pandey, Chandana Haldar, Dinesh K. Patel, Pralay Maiti

Erschienen in: Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology

Verlag: Springer Berlin Heidelberg

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Biodegradable polymers are being extensively used with great interest in areas of nanobiotechnology such as drug delivery, diagnostics, and other applications for clinical and biomedical research covering cardiovascular diseases, diabetes, osteogenesis, cancer, and tissue engineering. Various biodegradable polymers such as poly(lactic acid), poly(lactic-co-glycolic acid), poly (ε-caprolactone), chitosan, gelatin, and poly(alkyl cyanoacrylates) have been extensively utilized as polymeric materials and devices for targeted cellular and tissue-specific clinical applications to achieve maximal therapeutic efficacy with minimal or no side effects. Recently, polymeric nanoparticles have revolutionized the area of nanobiotechnology by creating new opportunities for advancing medical science and disease treatment. Polymeric nanoparticles have the potential to act as a carrier of drugs and active constituents to targeted sites, protecting them from the environment and controlling their release rates, thereby enhancing their biological activity and decreasing the adverse side effects. This article compiles updated information regarding various biodegradable polymers, methods of preparation of biodegradable polymeric nanoparticles, and their application in therapeutic and diagnostic strategies for various diseases. This article will support research scientists and clinical physicians who are interested in the development and application of biodegradable polymeric nanoparticles as potential delivery systems for therapeutics.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Vorheriges Kapitel Hydroxyapatite-Packed Chitosan-PMMA Nanocomposite: A Promising Material for Construction of Synthetic Bone

Nächstes Kapitel Phytomedicine-Loaded Polymeric Nanomedicines: Potential Cancer Therapeutics

Katti DS, Lakshmi S, Langer R et al (2002) Toxicity, biodegradation and elimination of polyanhydrides. Adv Drug Deliv Rev 54:933–961

Jalil R, Nixon JR (1990) Biodegradable poly (lactic acid) and poly (lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J Microencapsul 7:297–325

Tice TR, Tabibi ES (1991) Parenteral drug delivery: injectables. In: Kydonieus A (ed) Treatise on controlled drug delivery: fundamentals optimization, applications. Dekker, New York, pp 315–339

Wu XS (1995) Preparation, characterization, and drug delivery applications of microspheres based on biodegradable lactic/glycolic acid polymers. In: Wise DL et al (eds) Encyclopedic handbook of biomaterials and bioengineering. Dekker, New York, pp 1151–1200

Li S (1999) Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids. J Biomed Mater Res 48:342–353

Orive G, Hernandez RM, Rodriguez Gascon A et al (2003) Drug delivery in biotechnology: present and future. Curr Opin Biotechnol 14:659–664

Langer R (1990) New methods of drug delivery. Science 249:1527–1533

Kayser O, Lemke A, Hernandez-Trejo N (2005) The impact of nanobiotechnology on the development of new drug delivery systems. Curr Pharm Biotechnol 6:3–5

Williams D (2004) Nanotechnology: a new look. Med Device Technol 15:9–10

10.

Cheng MMC, Cuda G, Bunimovich YL et al (2006) Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol 10:11–19

11.

Shaffer C (2005) Nanomedicine transforms drug delivery. Drug Discov Today 10:1581–1582

12.

Moghimi SM, Hunter AC, Murray JC (2005) Nanomedicine: current status and future prospects. FASEB J 19:311–330

13.

Jain KK (2003) Nanodiagnostics: application of nanotechnology in molecular diagnostics. Expert Rev Mol Diagn 3:153–161

14.

Kubik T, Bogunia-Kubik K, Sugisaka M (2005) Nanotechnology on duty in medical applications. Curr Pharm Biotechnol 6:17–33

15.

Emerich DF (2005) Nanomedicine-prospective therapeutic and diagnostic applications. Expert Opin Biol Ther 5:1–5

16.

Norakankorn C, Pan Q, Rempel GL et al (2010) Factorial experimental design on synthesis of functional core/shell polymeric nanoparticles via differential microemulsion polymerization. J Appl Polym Sci 116:1291–1298

17.

Rao JP, Geckeler KE (2011) Polymer nanoparticles: preparation techniques and size-control parameters. Prog Polym Sci 36:887–913

18.

Chenga J, Teplya BA, Sherifia I et al (2007) Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28:869–876

19.

Williams DF, Zhong SP (1994) Biodeterioration/biodegradation of polymeric medical devices in situ. Int Biodeter Biodegrad 34:95–130

20.

Coleman JW (2001) Nitric oxide in immunity and inflammation. Int Immunopharmacol 1:1397–1406

21.

Labow RS, Tang Y, McCloskey CB et al (2002) The effect of oxidation on the enzyme-catalyzed hydrolytic biodegradation of poly (urethan)s. J Biomater Sci Polym Ed 13:651–665

22.

Lee KH, Chu CC (2000) The role of superoxide ions in the degradation of synthetic absorbable sutures. J Biomed Mater Res 49:25–35

23.

Gopferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials 17:103–114

24.

Shalaby W, Park H (1994) Chemical modification of proteins and polysaccharides and its effect on enzyme-catalyzed degradation. In: Shalaby S (ed) Biomedical polymers. Hanser Publishers, Munich, pp 213–258

25.

Zhang Y, Zale S, Sawyer L et al (1997) Effects of metal salts on poly (dl-lactide-co-glycolide) polymer hydrolysis. J Biomed Mater Res 34:531–538

26.

Hakkarainen M, Albetsson AC, Karlsson S (1996) Weight losses and molecular weight changes correlated with the evolution of hydroxy-acids in simulated in vivo degradation of homo- and copolymers of PLA and PGA. Polym Degrad Stabil 52:283–291

27.

Loo SCJ, Tan WLJ, Khoa SM et al (2008) Hydrolytic degradation characteristics of irradiated multi-layered PLGA films. Int J Pharm 360:228–230

28.

Tsuji H, Shimizu K, Sato Y (2012) Hydrolytic degradation of poly (l-lactic acid): combined effects of UV treatment and crystallization. J Appl Polym Sci 125:2394–2406

29.

Singh NK, Banik RM, Kulriya PK et al (2009) Nanoparticle-induced biodegradation of poly(ε-caprolactone). Nanosci Nanotechnol Lett 1:52–56

30.

Singh NK, Purkayastha BD, Roy JK et al (2010) Nanoparticle-induced controlled biodegradation and its mechanism in poly (ε-caprolactone). Appl Mater Interfaces 2:69–81

31.

Singh NK, Purkayastha BD, Roy JK et al (2011) Tuned biodegradation using poly(hydroxybutyrate-co-valerate) nanobiohybrids: emerging biomaterials for tissue engineering and drug delivery. J Mater Chem 21:15919–15927

32.

Maiti P, Batt CA, Giannelis EP (2007) New biodegradable polyhydroxybutyrate/layered silicate nanocomposites. Biomacromolecules 8:3393–3400

33.

Yeh M-K, Davis SS, Coombes AGA (1996) Improving protein delivery from microparticles using blends of poly(d, l lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers. Pharm Res 13:1693–1698

34.

Brannon-Peppas L (1995) Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int J Pharm 116:1–9

35.

Tabata Y, Ikada Y (1990) Phagocytosis of polymer microspheres by macrophages. Adv Polym Sci 94:107–141

36.

Stolnik S, Illum L, Davis SS (1995) Long circulating microparticulate drug carriers. Adv Drug Deliv Rev 16:195–214

37.

Arshady R (1991) Preparation of biodegradable microspheres and microcapsules: 2. Polylactides and related polyesters. J Control Release 17:1–22

38.

Song C, Labhasetwar V, Guzman L et al (1995) Dexamethasone-nanoparticles for intra-arterial localization in restenosis in rats. Proc Int Symp Control Release Bioact Mater 22:444–445

39.

Dawson GF, Halbert GW (2000) The in vitro cell association of invasin coated polylactide-co-glycolide nanoparticles. Pharm Res 17:1420–1425

40.

Muller RH, Maaben S, Weyhers H et al (1996) Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles. Int J Pharm 138:85–94

41.

Leroux JC, Allemann E, De Jaeghere F et al (1996) Biodegradable nanoparticles-from sustained release formulations to improved site specific drug delivery. J Control Release 39:339–350

42.

Niwa T, Takeuchi H, Hino T et al (1993) Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d, l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J Control Release 25:89–98

43.

Murakami H, Kobayashi M, Takeuchi H et al (1999) Preparation of poly (d, l-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method. Int J Pharm 187:143–152

44.

Wattenberg LW, Wiedmann TS, Estensen RD et al (1997) Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res 57:5489–5492

45.

Lee YH, Mei F, Bai MY et al (2010) Release profile characteristics of biodegradable-polymer-coated drug particles fabricated by dual-capillary electrospray. J Control Release 145:58–65

46.

Jain AK, Swarnakar NK, Das M et al (2011) Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model. Mol Pharm 8:1140–1151

47.

Fagui AE, Amiel C (2012) PLA nanoparticles coated with a β-cyclodextrin polymer shell: preparation, characterization and release kinetics of a hydrophobic compound. Int J Pharmaceut 436:644–651. doi:10.1016/j.ijpharm.2012.07.052

48.

Byun Y, Hwang JB, Bang SH et al (2011) Formulation and characterization of α-tocopherol loaded poly ε-caprolactone (PCL) nanoparticles. LWT Food Sci Technol 44:24–28

49.

Anitha A, Deepagan VG, Divya Rani VV et al (2011) Preparation, characterization, in vitro drug release and biological studies of curcumin loaded dextran sulphate–chitosan nanoparticles. Carbohydr Polym 84:1158–1164

50.

Vanderhoff JW, Mohamed S, Aasser El et al (1979) Polymer emulsification process. US Patent 4,177,177

51.

Couvreur P, Dubernet C, Puisieux F (1995) Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur J Pharm Biopharm 41:2–13

52.

Anton N, Benoit JP, Saulnier P (2008) Design and production of nanoparticles formulated from nano-emulsion templates—a review. J Control Release 128:185–199

53.

Julienne VMC, Benoit JP (1996) Preparation, purification and morphology of polymeric nanoparticles as drug carriers. Pharm Acta Helv 71:121–128

54.

Vandorpe J, Schacht E, Stolnik S et al (1996) Poly(organo phosphazene) nanoparticles surface modified with poly(ethylene oxide). Biotechnol Bioeng 52:89–95

55.

Song CX, Labhasetwar V, Murphy H et al (1997) Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43:197–212

56.

Lemoine D, Preat V (1998) Polymeric nanoparticles as delivery system for influenza virus glycoproteins. J Control Release 54:15–27

57.

Zambaux MF, Bonneaux F, Gref R et al (1998) Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Control Release 50:31–40

58.

Quellec P, Gref R, Dellacherie E et al (1999) Protein encapsulation within poly(ethylene glycol)-coated nanospheres. II. Controlled release properties. J Biomed Mater Res A 47:388–395

59.

Bilati U, Allemann E, Doelker E (2003) Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method. Pharm Dev Technol 8:1–9

60.

Mainardes RM, Evangelista RC (2005) Praziquantel-loaded PLGA nanoparticles: preparation and characterization. J Microencapsul 22:13–24

61.

Quintanar-Guerrero D, Allemann E, Fessi H et al (1998) Preparation techniques and mechanism of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm 24:1113–1128

62.

Bindschaedler C, Gurny R, Doelker E (1990) Process for preparing a powder of water-insoluble polymer which can be redispersed in a liquid phase, the resulting powder and utilization thereof. US Patent 4,968,350

63.

Allemann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 87:247–253

64.

Zhang Z, Grijpma DW, Feijen J (2006) Poly (trimethylene carbonate) and monomethoxy poly (ethylene glycol)-block-poly(trimethylene carbonate) nanoparticles for the controlled release of dexamethasone. J Control Release 111:263–270

65.

Fessi H, Puisieux F, Devissaguet JP et al (1989) Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 55:1–4

66.

Mishra B, Patel BB, Tiwari S (2010) Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine 6:9–24

67.

Thioune O, Fessi H, Devissaguet JP et al (1997) Preparation of pseudolatex by nanoprecipitation: influence of the solvent nature on intrinsic viscosity and interaction constant. Int J Pharm 146:233–238

68.

Moinard-Checot D, Chevalier Y, Briancon S et al (2008) Mechanism of nanocapsules formation by the emulsion–diffusion process. J Colloid Interface Sci 317:458–468

69.

Kim E, Yang J, Choi J et al (2009) Synthesis of gold nanorod-embedded polymeric nanoparticles by a nanoprecipitation method for use as photothermal agents. Nanotechnology 20:365602

70.

Legrand P, Lesieur S, Bochot A et al (2007) Influence of polymer behaviour in organic solution on the production of polylactide nanoparticles by nanoprecipitation. Int J Pharm 344:33–43

71.

Nehilla BJ, Bergkvist M, Popat KC et al (2008) Purified and surfactant free coenzyme Q10-loaded biodegradable nanoparticles. Int J Pharm 348:107–114

72.

Yallapu MM, Gupta BK, Jaggi M et al (2010) Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J Colloid Interface Sci 351:19–29

73.

Jeong YI, Cho CS, Kim SH et al (2001) Preparation of poly (d-l-lactide-co-glycolide) nanoparticles without surfactant. J Appl Polym Sci 80:2228–2236

74.

Kostog M, Kohler S, Liebert T et al (2010) Pure cellulose nanoparticles from trimethylsilyl cellulose. Macromol Symp 294:96–106

75.

Barichello JM, Morishita M, Takayama K et al (1999) Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev Ind Pharm 25:471–476

76.

Nemati F, Dubernet C, Fessi H et al (1996) Reversion of multidrug resistance using nanoparticles in vitro: influence of the nature of the polymer. Int J Pharm 138:237–246

77.

Mu L, Feng SS (2003) A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. J Control Release 86:33–48

78.

Prabha S, Zhou W-Z, Panyam J et al (2002) Size-dependency of nanoparticle-mediated gene transfection studies with fractionated nanoparticles. Int J Pharm 244:105–115

79.

Sanchez A, Vila Jato JL, Alonso MJ (1993) Development of biodegradable microspheres and nanospheres for the controlled release of cyclosporine. Int J Pharm 99:263–273

80.

Gomez-Gaete C, Tsapis N, Besnard M et al (2007) Encapsulation of dexamethasone into biodegradable polymeric nanoparticles. Int J Pharm 331:153–159

81.

Labhasetwar V, Song C, Humphrey W et al (1998) Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J Pharm Sci 87:1229–1234

82.

Yin Y, Chen DW, Wei XY et al (2007) Lectin-conjugated PLGA nanoparticles loaded with thymopentin: ex vivo bioadhesion and in vivo biodistribution. J Control Release 123:27–38

83.

Jin C, Bai L, Wu H et al (2008) Cellular uptake and radiosensitisation off SR-2508 loaded PLGA nanoparticles. J Nanopart Res 10:1045

84.

Fonseca C, Simoes S, Gaspar R (2002) Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J Control Release 83:273–286

85.

Danhier F, Lecouturier N, Vroman B et al (2009) Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation. J Control Release 133:11–17

86.

Derakhshandeh K, Erfan M, Dadashzadeh S (2007) Encapsulation of 9- nitrocamptothecin, a novel anticancer drug, in biodegradable nanoparticles: factorial design, characterization and release kinetics. Eur J Pharm Biopharm 66:34–41

87.

Gurny R, Peppas NA, Harrington DD et al (1981) Development of biodegradable and injectable lattices for controlled release potent drugs. Drug Dev Ind Pharm 7:1–25

88.

Landry FB, Bazile DV, Spenlehauer G et al (1996) Influence of coating agents on the degradation of poly(d, l-lactic acid) nanoparticles in model digestive fluids (USP XXII). Biomaterials 6:195–202

89.

Tobio M, Gref R, Sanchez A et al (1998) Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm Res 15:270–275

90.

Ueda H, Kreuter J (1997) Optimization of the preparation of loperamide-loaded poly (l-lactide) nanoparticles by high pressure emulsification solvent evaporation. J Microencapsul 14:593–605

91.

Ueda M, Iwara A, Kreuter J (1998) Influence of the preparation methods on the drug release behavior of loperamide-loaded nanoparticles. J Microencapsul 15:361–372

92.

Budhian A, Siegel SJ, Winey KI (2005) Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol. J Microencapsul 22:773–785

93.

Matsumoto J, Nakada Y, Sakurai K et al (1999) Preparation of nanoparticles consisted of poly (l-lactide)–poly (ethylene glycol)–poly (l-lactide) and their evaluation in vitro. Int J Pharm 185:93–101

94.

Mainardes RM, Gremiao MPD, Brunetti IL et al (2009) Zidovudine-loaded PLA and PLA-PEG blend nanoparticles: influence of polymer type on phagocytic uptake by polymorphonuclear cells. J Pharm Sci 98:257–267

95.

Konan YN, Berton M, Gurny R et al (2003) Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200 nm nanoparticles. Eur J Pharm Sci 18:241–249

96.

Perez C, Sanchez A, Putnam D et al (2001) Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Control Release 75:211–224

97.

Xing J, Zhang D, Tan T (2007) Studies on the oridonin-loaded poly (d, l-lactic acid) nanoparticles in vitro and in vivo. Int J Biol Macromol 40:153–158

98.

Sonaje K, Italia JL, Sharma G et al (2007) Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats. Pharm Res 24:899–908

99.

Sheng Y, Yuan Y, Liu C et al (2009) In vitro macrophage uptake and in vivo biodistribution of PLA-PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content. J Mater Sci Mater Med 20:1881–1891

100.

Cheng FY, Wang SF, Su CH et al (2008) Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes. Biomaterials 29:2104–2112

101.

Yoo HS, Oh JE, Lee KH et al (1999) Biodegradable nanoparticles containing PLGA conjugate for sustained release. Pharm Res 16:1114–1118

102.

Sahana DK, Mittal G, Bhardwaj V et al (2008) PLGA nanoparticles for oral delivery of hydrophobic drugs: influence of organic solvent on nanoparticle formation and release behavior in vitro and in vivo using estradiol as a model drug. J Pharm Sci 97:1530–1542

103.

Esmaeili F, Ghahremani MH, Ostad SN et al (2008) Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA–PEG–folate conjugate. J Drug Target 16:415–423

104.

Teixeira M, Alonso MJ, Pinto MM et al (2005) Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone. Eur J Pharm Biopharm 59:491–500

105.

Allemann E, Leroux JC, Gurny R et al (1993) In vitro extended release properties of drug-loaded poly(d, l-lactic acid) nanoparticles produced by salting-out procedure. Pharm Res 10:1732–1737

106.

Ammoury N, Fessi H, Devissaguet J-P et al (1990) In vitro release pattern of indomethacin from poly(d, l-lactide) nanocapsules. J Pharm Sci 79:763–767

107.

Ammoury N, Fessi H, Devissaguet J-P et al (1991) Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d, l-lactide) and poly(isobutylcyanoacrylate) nanocapsules in rats. Pharm Res 8:101–105

108.

Elvassore N, Bertucco A, Caliceti P (2001) Production of insulin-loaded poly(ethylene glycol)/poly(l-Lactide) (PEG/PLA) nanoparticles by gas antisolvent techniques. J Pharm Sci 90:1628–1636

109.

Molpeceres J, Guzman M, Aberturas MR et al (1996) Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement. J Pharm Sci 85:206–213

110.

Shenoy DB, Amiji MM (2005) Poly (ethylene oxide)-modified poly (epsiloncaprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer. Int J Pharm 293:261–270

111.

Shah LK, Amiji MM (2006) Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS. Pharm Res 23:2638–2645

112.

Zheng D, Li X, Xu H et al (2009) Study on docetaxel-loaded nanoparticles with high antitumor efficacy against malignant melanoma. Acta Biochim Biophys Sin (Shanghai) 41:578–587

113.

Prabu P, Chaudhari AA, Dharmaraj N et al (2008) Preparation, characterization, in-vitro drug release and cellular uptake of poly (caprolactone) grafted dextran copolymeric nanoparticles loaded with anticancer drug. J Biomed Mater Res 90:1128–1136

114.

Lu Z, Yeh TK, Tsai M et al (2004) Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy. Clin Cancer Res 10:7677–7684

115.

Kaur A, Jain S, Tiwary AK (2008) Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation. Acta Pharm 58:61–74

116.

Bajpai AK, Choubey J (2006) Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate. J Mater Sci Mater Med 17:345–358

117.

Bajpai AK, Choubey J (2005) Release study of sulphamethoxazole controlled by swelling of gelatin nanoparticles and drug–biopolymer interaction. J Macromol Sci 42:253–275

118.

Sarmento B, Ribeiro A, Veiga F et al (2007) Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res 12:2198–2206

119.

Gunatillake P, Mayadunne R, Adhikari R (2006) Recent developments in biodegradable synthetic polymers. Biotechnol Annu Rev 12:301–347

120.

Terasaka S, Iwasaki Y, Shinya N et al (2006) Fibrin glue and polyglycolic acid nonwoven fabric as a biocompatible dural substitute. Neurosurgery 58:134–139

121.

Maurus PB, Kaeding CC (2004) Bioabsorbable implant material review. Oper Tech Sports Med 12:158–160

122.

Urayama H, Kanamori T, Kimura Y (2002) Properties and biodegradability of polymer. Macromol Mater Eng 287:116–121

123.

Sawai D, Takahashi K, Imamura T et al (2002) Preparation of oriented β-form poly(l-lactic acid) by solid-state extrusion. J Polym Sci B Polym Phys 40:95–104

124.

Cohen S, Alonso MJ, Langer R (1994) Novel approaches to controlled release antigen delivery. Int J Technol Assess Health Care 10:121–130

125.

Jean-Christophe L, Eric A, Fanny DJ et al (1996) Biodegradable nanoparticles-from sustained release formulations to improved site specific drug delivery. J Control Release 39:339–350

126.

Kumari A, Yadav SK, Pakade YB et al (2011) Nanoencapsulation and characterization of Albizia chinensis isolated antioxidant quercitrin on PLA nanoparticles. Colloids Surf B Biointerfaces 82:224–232

127.

Hu FX, Neoh KG, Kang ET (2006) Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials 27:5725–5733

128.

Leenstag JW, Pennings AJ, Bos RRM et al (1987) Resorbable materials of polyl-lactides VI. Plates and screws for internal fracture fixation. Biomaterials 8:70–73

129.

Pathiraja AG, Raju A (2003) Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 5:1–16

130.

Sheridan MH, Shea LD, Peters MC (2000) Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control Release 64:91–102

131.

Panyam J, Labhasetwar V (2003) Dynamics of endocytosis and exocytosis of poly (l-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res 20:212–220

132.

Prabha S, Labhasetwar V (2004) Critical determinants in PLGA/PLA nanoparticle-mediated gene expression. Pharm Res 21:354–364

133.

Athanasiou KA, Niederauer GG, Agrawal CM (1996) Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 17:93–102

134.

Mittal G, Sahana DK, Bhardwaj V et al (2007) Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release 119:77–85

135.

Hans ML, Lowman AM (2002) Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci 6:319–327

136.

Feng SS (2004) Nanoparticles of biodegradable polymers for new-concept chemotherapy. Expert Rev Med Devices 1:115–125

137.

Redhead HM, Davis SS, Illum L (2001) Drug delivery in poly (lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. J Control Release 70:353–363

138.

Nicoli S, Santi P, Couvreur P et al (2001) Design of triptorelin loaded nanospheres for transdermal iontophoretic administration. Int J Pharm 214:31–35

139.

Nair LS, Laurencin CT (2006) Polymers as biomaterials for tissue engineering and controlled drug delivery. In: Kaplan D, Lee K (eds) Tissue engineering I, Advances in biochemical engineering/biotechnology. Springer, Berlin, pp 47–90

140.

Mondrinos MJ, Dembzynski R, Lu L, Byrapogu VK, Wootton DM, Lelkes PI, Zhou J (2006) Porogen-based solid freeform fabrication of polycaprolactone-calcium phosphate scaffolds for tissue engineering. Biomaterials 27:4399–4408

141.

Gao H, Wang YN, Fan YG et al (2005) Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl)amino-6-deoxy)-beta-cyclodextrin and its properties as the new carrier of protein delivery system. J Control Release 107:158–173

142.

Kim SY, Lee YM (2001) Taxol-loaded block copolymer nanospheres composed of methoxy poly (ethylene glycol) and poly (epsilon-caprolactone) as novel anticancer drug carriers. Biomaterials 22:1697–1704

143.

Damge C, Maincent P, Ubrich N (2007) Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J Control Release 117:163–170

144.

Changyong C, Chae SY, Jae-Won N (2006) Thermosensitive poly(nisopropylacrylamide)-b-poly(ε-caprolactone) nanoparticles for efficient drug delivery system. Polymer 47:4571

145.

Espuelas MS, Legrand P, Loiseau PM et al (2002) In vitro antileishmanial activity of amphotericin B loaded in poly (epsilon-caprolactone) nanospheres. J Drug Target 10:593–599

146.

Yordanov G, Abrashev N, Dushkin C (2010) Poly(n-butylcyanoacrylate) submicron particles loaded with ciprofloxacin for potential treatment of bacterial infections. Prog Colloid Polym Sci 137:53–59

147.

Yordanov R, Skrobanska A, Evangelatov A (2012) Entrapment of epirubicin in poly (butyl cyanoacrylate) colloidal nanospheres by nanoprecipitation: formulation development and in vitro studies on cancer cell lines. Colloids Surf B Biointerfaces 92:98–105

148.

Balland O, Pinto-Alphandary H, Pecquet S et al (1994) The uptake of ampicillin-loaded nanoparticles by murine macrophages infected with Salmonella typhimurium. J Antimicrob Chemother 33:509–522

149.

Briones E, Colino CI, Lanao JM (2008) Delivery systems to increase the selectivity of antibiotics in phagocytic cells. J Control Release 125:210–227

150.

Forestier F, Gerrier P, Chaumard C et al (1992) Effect of nanoparticle-bound ampicillin on the survival of Listeria monocytogenes in mouse peritoneal macrophages. J Antimicrob Chemother 30:173–179

151.

Nishioka Y, Yoshino H (2001) Lymphatic targeting with nanoparticulate system. Adv Drug Deliv Rev 47:55–64

152.

Gulyaev AE, Gelperina SE, Skidan IN et al (1999) Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res 16:1564–1569

153.

Ramge P, Unger RE, Oltrogge J et al (2000) Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCE)-nanoparticles by human and bovine primary brain capillary endothelial cells. Eur J Neurosci 12:1931–1940

154.

Gursoy A, Eroglu L, Ulutin S et al (1989) Evaluation of indomethacin nanocapsules for their physical stability and inhibitory activity on inflammation and platelet aggregation. Int J Pharm 52:101–108

155.

Abraham DJ (2006) Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan. J Control Release 114:1–14

156.

Baruch L, Machluf M (2006) Alginate-chitosan complex coacervation for cell encapsulation: effect on mechanical properties and on long-term viability. Biopolymers 82:570–579

157.

Nordtveit RJ, Varum KM, Smidstrod O (1996) Degradation of partially N-acetylated chitosans with hen egg white and human lysozyme. Carbohydr Polym 29:163–167

158.

Shi C, Zhu Y, Ran X et al (2006) Therapeutic potential of chitosan and its derivatives in regenerative medicine. J Surg Res 133:185–192

159.

Martinac A, Filipovi J, Voinovich D et al (2005) Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery. Int J Pharm 291:69–77

160.

Illum L, Jabbal-Gill I, Hinchcliffe M et al (2001) Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev 51:81–96

161.

Onishi H, Takahashi H, Yoshiyasu M et al (2001) Preparation and in vitro properties of N-Succinylchitosan or carboxymethylchitin-mitomycin C conjugate microparticles with specified size. Drug Dev Ind Pharm 27:659–667

162.

De Campos AM, Sanchez A, Alonso MJ (2001) Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface, Application to cyclosporin A. Int J Pharm 224:159–168

163.

Wu Y, Yang W, Wang C et al (2005) Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate. Int J Pharm 295:235–245

164.

Yamamoto M, Ikada Y, Tabata Y (2001) Controlled release of growth factors based on biodegradation of gelatin hydrogel. J Biomater Sci Polym Ed 12:77–88

165.

Balakrishnan B, Jayakrishnan A (2005) Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials 26:3941–3951

166.

Yao CH, Liu BS, Hsu SH et al (2004) Biocompatibility and biodegradation of a bone composite containing tricalcium phosphate and genipin crosslinked gelatin. J Biomed Mater Res 69A:709–717

167.

Ikada Y, Tabata Y (1998) Protein release from gelatin matrices. Adv Drug Deliv Rev 31:287–301

168.

Li JK, Wang N, Wu XS (1998) Gelatin nanoencapsulation of protein/peptide drugs using an emulsifier-free emulsion method. J Microencapsul 15:163–172

169.

Wheatley DJ, Raco L, Bernacca GM et al (2000) Polyurethane: material for the next generation of heart valve prostheses? Eur J Cardiothorac Surg 17:440–448

170.

Ganta RS, Piesco PN, Long P (2003) Vascularization and tissue infiltration of a biodegradable polyurethane matrix. J Biomed Mater Res 64A:242–248

171.

Gangadharam PRJ, Kailasam S, Srinivasan S et al (1994) Experimental chemotherapy of tuberculosis using single dose treatment with isoniazid in biodegradable polymers. Br J Antimicrobial Chemotherapy 33:265–271

172.

Kailasam S, Wise DL, Gangadharam PRJ (1994) Bioavailability and chemotherapeutic activity of clofazimine against Mycobacterium avium complex infections in beige mice following a single implant of a biodegradable polymer. J Antimicrob Chemother 33:273–279

173.

Kunou N, Ogura Y, Hashizoe M et al (1996) Biodegradable scleral implant for controlled intraocular delivery of ganciclovir. Proc Int Symp Control Release Bioact Mater 23:711–712

174.

Wang G, Tucker IG, Roberts MS et al (1996) In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly (d, l-lactide-co-glycolide). Pharm Res 13:1059–1064

175.

Ramchandani M, Robinson D (1998) In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. J Control Release 54:167–175

176.

Lin SS, Ueng SW, Liu SJ et al (1999) Development of biodegradable antibiotic delivery system. Clin Orthop 5:240–250

177.

Lemmouchi Y, Schacht E, Kageruka P et al (1998) Biodegradable polyesters for controlled release of trypanocidal drugs: in vitro and in vivo studies. Biomaterials 19:1827–1837

178.

Song CX, Labhasetwar V, Levy RJ (1996) Modulation of release rates from double-layer poly(lactic-co-glycolic acid) films for periadventital implants in restenosis. Proc Int Symp Control Release Bioact Mater 23:473–474

179.

Hsu Y-Y, Gresser JD, Stewart RR et al (1996) Mechanisms of isoniazid release from poly(d, l-lactide-co-glycolide) matrices prepared by dry-mixing and low density polymeric foam methods. J Pharm Sci 85:706–713

180.

Cheng L, Lei L, Guo S (2010) In vitro and in vivo evaluation of praziquantel loaded implants based on PEG/PCL blends. Int J Pharm 387:129–138

181.

Pandey SK, Banik RM (2011) Extractive fermentation for enhanced production of alkaline phosphatase from Bacillus licheniformis MTCC 1483 using aqueous two-phase systems. Bioresour Technol 102:4226–4231

182.

Hayashida K, Kanda K, Yaku H et al (2007) Development of an in vivo tissue-engineered, autologous heart valve (the biovalve): preparation of prototype model. J Thorac Cardiovasc Surg 134:152–159

183.

Daebrtiz HS, Sachweh SJ, Hermanns B et al (2003) Introduction of a flexible polymeric heart valve prothesis with special design for mitral position. Circulation 108:II-134–II-139

Titel: Biodegradable Polymers for Potential Delivery Systems for Therapeutics
verfasst von: Sanjeev K. Pandey
Chandana Haldar
Dinesh K. Patel
Pralay Maiti
Verlag: Springer Berlin Heidelberg
Buch: Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology
Print ISBN: 978-3-642-40122-0

Electronic ISBN: 978-3-642-40123-7

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/12_2012_198

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht