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01.07.2011 | Research paper

Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers

verfasst von: Li Zhan, Geng Yanxia, Zhang Xiaoyong, Qi Wei, Fan Qiaohui, Li Yan, Jiao Zongxian, Wang Jianjun, Tang Yuqin, Duan Xiaojiang, Wu Wangsuo

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2011

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Abstract

Technetium-99 (^99mTc) was used as an isotope tracer to study the biodistribution of oxidized multi-walled carbon nanotubes (oMWCNTs) and/or graphene oxide nanoplatelets (GONP) after intravenous administration (i.v.). The authors also investigated the histological impact of non-radiolabeled oMWCNT or GONP as they passed through systemic circulation and their excretion pathways in comparison to co-exposure groups of both (oMWCNTs and GONP). Results indicated that oMWCNTs were mainly excreted through feces rather than urine. From the blood, oMWCNTs first entered the stomach, then intestines via chyme, and were finally excreted in feces. GONP also followed this pathway, but could also be excreted through urine when co-exposed with oMWCNTs. In summary, the biodistribution patterns and excretion rates of the nanomaterials in vivo depended on their composition and chemical modifications. A new mechanism is proposed to explain how chemical modification groups affect the behavior of nanomaterials in vivo. The behavior and fate of GONP depended strongly on oMWCNTs in mice in vivo, but the GONP did not affect deeply biodistribution and excretion pattern of oMWCNTs in co-exposure.

Vorheriger Artikel Nano-structuring of PTFE surface by plasma treatment, etching, and sputtering with gold

Nächster Artikel Aerosol characterization and lung deposition of synthesized TiO2 nanoparticles for murine inhalation studies

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Bianco A, Kostarelos K, Partidos CD, Prato M (2005) Biomedical applications of functionalized carbon nanotubes. Chem Commun 571–577

Cai D, Mataraza JM, Qin ZH, Huang ZP, Huang JY, Chiles TC, Carnahan D, Kempa K, Ren ZF (2005) Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nat Methods 2:449–454CrossRef

Chen CC, Lin YP, Wang CW, Tzeng HC, Wu CH, Chen YC, Chen CP, Chen LC, Wu YC (2006) DNA-gold nanorod conjugates for remote control of localized gene expression by near infrared irradiation. J Am Chem Soc 128:3709–3715CrossRef

Chen X, Zettl A, Bertozzi C (2007) A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci USA 104:8218–8222CrossRef

Cherkuri P, Bachilo SM, Litovsky SH, Weisman RB (2004) Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J Am Chem Soc 126:15638CrossRef

Cherukuri P, Gannon CJ, Leeuw TK, Schmidt HK, Smalley RE, Curley SA, Weisman RB (2006) Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc Natl Acad Sci USA 103:18882–18886CrossRef

Farokhzad OC, Jon SY, Khademhosseini A, Lavan DA, Langer R (2004) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci USA 103:6315–6320CrossRef

Firme CP III, Bandaru PR (2009) Toxicity issues in the application of carbon nanotubes to biological systems. Nanomedicine. doi:10.1016/j.nano.2009.07.003

Gao XH, Cui YY, Levenson RM, Chung LWK, Nie SM (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotech 22:969–976CrossRef

Geng Y, Wang SJ, Kim JK (2009) Preparation of graphite nanoplatelets and graphene sheets. J Colloid Interf Sci 336:298–592CrossRef

Guo JX, Zhang X, Li QN, Li WX (2007) Biodistribution of functionalized multiwall carbon nanotubes in mice. Nucl Med Biol 34:579–583CrossRef

Kam NW, O'connell M, Wisdom JA, Dai HJ (2005) Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci USA 102:11600–11605CrossRef

Lacerda L, Soundararajan A, Singh R, Pastorin G, Al-Jamal KT, Turton J, Frederik P, Herrero MA, Li SP, Bao AD, Emfietzoglou D, Mather A, Phillips WT, Prato M, Bianco A, Goins B, Kostarelos K (2008) Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv Mater 20:225–230CrossRef

Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R (2000) Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotech 18:410–414CrossRef

Li Q, Xiu Y, Zhang X (2002) Preparation of 99mTc-C60(OH)x and its biodistribution studies. Nucl Med Biol 29:707–710CrossRef

Li Z, Qi W, Geng YX, Pan DQ, Lu Y, Xu JZ, Wu WS (2010) Effect of MWCNTs on gastric emptying in mice. Nanoscale Res Lett. doi:10.1007/s11671-010-9803-y

Liu Z, Davis C, Cai W, He L, Chen X, Dai H (2007) In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotech 2:47–52CrossRef

Maier-Hauff K, Rothe R, Scholz R, Gneveckow U, Wust P, Thiesen B, Feussner A, von Deimling A, Waldoefner N, Felix R, Jordan A (2007) Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme. J Neurooncol 81:53–60CrossRef

Marsh M, Mcmahon HT (1999) The structural era of endocytosis. Science 285:215CrossRef

Meyer JC, Geim AK, Katsnelson MI, Novoselov KS, Booth TJ, Roth S (2007) The structure of suspended graphene sheets. Nature 446:60–63CrossRef

Mukherjee S, Ghosh RN, Maxfield FR (1997) Endocytosis. Physiol Rev 77:759

Pantarotto D, Briand JP, Prato M, Bianco A (2004) Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun 1:16–17CrossRef

Service RF (2005) Nanotechnology takes aim at cancer. Science 310:1132–1134CrossRef

Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K (2006) Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 103:3357–3362CrossRef

Sinha R, Kim GJ, Nie SM, Shin DM (2006) Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 5:1909–1917CrossRef

Wang XK, Chen CL, Hu WP, Ding AP, Xu D, Zhou X (2005) Sorption of ²⁴³Am(III) to multiwall carbon nanotubes. Environ Sci Technol 39:2856–2860CrossRef

Wang G, Shen X, Yao J, Park J (2009) Graphene nanosheets for enhanced lithium storage in lithium ion batteries. Carbon. doi:10.1016/j.carbon.2009.03.05

Whitesides GM (2003) The “right” size in nanobiotechnology. Nat Biotech 21:1161–1165CrossRef

Xu JY, Li QN, Li JG, Ran TC, Wu SW, Song WM, Chen SL, Li WX (2007) Biodistribution of ^99mTc-C60(OH)x in Sprague-Dawley rats after intratracheal instillation. Carbon 45:1865–1870CrossRef

Yang ST, Wang X, Jia G, Gu YQ, Wang TC, Nie HY, Ge CC, Wang HF, Liu YF (2008) Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol Lett 181:182–189CrossRef

Zheng GF, Patolsky F, Cui Y, Wang WU, Lieber CM (2005) Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotech 23:1294–1301CrossRef

Titel: Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers
verfasst von: Li Zhan
Geng Yanxia
Zhang Xiaoyong
Qi Wei
Fan Qiaohui
Li Yan
Jiao Zongxian
Wang Jianjun
Tang Yuqin
Duan Xiaojiang
Wu Wangsuo
Publikationsdatum: 01.07.2011
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2011
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-010-0185-y

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