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2019 | OriginalPaper | Buchkapitel

7. Cancer Gene Diagnosis of Singh et al. Microarray

verfasst von : Shuichi Shinmura

Erschienen in: High-dimensional Microarray Data Analysis

Verlag: Springer Singapore

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Abstract

Chapter 1 explained the new theory of discriminant analysis after R. A. Fisher (Theory). The theory solved five problems completely. Especially, Revised IP-OLDF (RIP) and Method2 firstly succeeded in the cancer gene analysis. RIP could find six microarrays were LSD (Fact3). LINGO Program3 of Method2 could decompose the microarray into many SMs and another noise subspace (Fact4). In Chap. 2, we make signal data made by RIP discriminant scores (RipDSs). Our breakthrough opens the new frontier of cancer gene diagnosis and malignancy indexes. We find the new problem (Problem6): “Why could no researchers find the linear separable facts in microarrays and SM from 1970?” In this book, we explain the several answers of Problem6. In this chapter, we survey how to make different RipDSs from many SMs. It explains why microarray consists of many SMs and the different RipDSs. By these results, we wish to classify SMs into several categories of malignancy indexes in the future.

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Fußnoten
1
Dinesh Singh, Phillip G. Febbo, Kenneth Ross, Donald G. Jackson, Judith Manola, Christine Ladd, Pablo Tamayo, Andrew A. Renshaw, Anthony V. D’Amico, Jerome P. Richie, Eric S. Lander, Massimo Loda, Philip W. Kantoff, Todd R. Golub, and William R. Sellers.
 
Literatur
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Zurück zum Zitat Sall JP, Creighton L, Lehman A (2004) JMP start statistics (3rd edn). SAS Institute Inc. USA (Shinmura S. edits Japanese version) Sall JP, Creighton L, Lehman A (2004) JMP start statistics (3rd edn). SAS Institute Inc. USA (Shinmura S. edits Japanese version)
Zurück zum Zitat Schrage L (2006) Optimization modeling with LINGO. LINDO Systems Inc. (Shinmura S translates Japanese version) Schrage L (2006) Optimization modeling with LINGO. LINDO Systems Inc. (Shinmura S translates Japanese version)
Zurück zum Zitat Shinmura S (2016) New theory of discriminant analysis after R. Fisher. Springer, TokyoCrossRef Shinmura S (2016) New theory of discriminant analysis after R. Fisher. Springer, TokyoCrossRef
Zurück zum Zitat Shinmura S (2017) Cancer gene analysis by Singh et al. microarray data. ISI2017, pp 1–6 Shinmura S (2017) Cancer gene analysis by Singh et al. microarray data. ISI2017, pp 1–6
Zurück zum Zitat Shinmura S (2018a) Cancer gene analysis of microarray data. In: 3rd IEEE/ACIS international conference on BCD’18, pp 1–6 Shinmura S (2018a) Cancer gene analysis of microarray data. In: 3rd IEEE/ACIS international conference on BCD’18, pp 1–6
Zurück zum Zitat Shinmura S (2018b) First success of cancer gene analysis by microarrays. In: Biocomp’18, pp 1–7 Shinmura S (2018b) First success of cancer gene analysis by microarrays. In: Biocomp’18, pp 1–7
Zurück zum Zitat Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8(1):68–74. (https://doi.org/10.1038/nm0102-6) Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8(1):68–74. (https://​doi.​org/​10.​1038/​nm0102-6)
Zurück zum Zitat Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D’Amico AV, Richie JP, Lander ES, Lada M, Kantoff PW, Golub TR, Sellers WR (2002) Gene expression correlates of clinical prostate cancer behavior. Cancer Cell 1(2):203–209 Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D’Amico AV, Richie JP, Lander ES, Lada M, Kantoff PW, Golub TR, Sellers WR (2002) Gene expression correlates of clinical prostate cancer behavior. Cancer Cell 1(2):203–209
Metadaten
Titel
Cancer Gene Diagnosis of Singh et al. Microarray
verfasst von
Shuichi Shinmura
Copyright-Jahr
2019
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-13-5998-9_7

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