Cell mechanics: The role of simulation

Computer simulation is one of the most powerful tools available to the applied mechanician to understand the complexities of mechanical behavior. It has revolutionized design of virtually all man-made structures from aircraft and buildings to cell phones and computers. It has also become a relatively important tool in biomechanics and simulation of tissues and implants has become routine. Indeed we appear to be on the verge of patient specific simulation becoming a critical tool in orthopaedic and cardiovascular surgery. However, its use as a tool of basic science is much less clear. In this chapter we explore the potential for mechanical simulation to contribute to improve fundamental understanding of biology. We consider the challenges of creating a model of a mechanobiological system with experimental validation. We propose that the area of cell mechanics is a particular area where simulation can make critically important contributions to understanding basic physiology and pathology and outline potential areas of future advancement.