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2015 | OriginalPaper | Buchkapitel

Characterizing Synthetic Biology Through Its Novel and Enhanced Functionalities

verfasst von : Christian Pade, Bernd Giese, Stefan Koenigstein, Henning Wigger, Arnim von Gleich

Erschienen in: Synthetic Biology

Verlag: Springer International Publishing

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Abstract

What distinguishes synthetic biology from earlier approaches in biology and biotechnology? What are future applications that may possibly be realized through synthetic biology? What can be expected from synthetic biology with respect to the benefits it may provide as well as the risks it may pose? This chapter puts forward the idea that these questions, among others that regard the promises and threats of this new and emerging field of science and technology, can be explored by applying the concept of functionality to synthetic-biological structures and systems. Functionality, in this respect, is defined as a certain physicochemical or biological effect that can be brought about by a (synthetic-) biological object. This effect, in turn, has repercussions on the wider systems context the respective object appears in. Looking at the various hierarchical levels of biological life, functionalities that have already been realized through synthetic-biological approaches, as well as those that may be realized through future research and development, are systematically analyzed. Based on this analysis, applications that make use of these functionalities thus far, or may do so in the future, are presented. Furthermore, it is investigated how the functionalities may change the hazardous properties or exposure behavior of the respective structures or systems and thus potentially increase the risk associated with them.

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Vorheriges Kapitel Complexity in Synthetic Biology: Unnecessary or Essential?

Nächstes Kapitel Synthetic Biology: The Next Step Forward for Industrial Biotechnology

A similar categorization into five “levels of complexity” is suggested by GR et al. (2008).

For reasons of better readability and cross-reference, functionalities are set in small capitals preceded by an arrow (“→”). All functionalities discussed in this chapter are also summarized in Table 1.

Ajo-Franklin, C. M., Drubin, D. A., Eskin, J. A., Gee, E. P., Landgraf, D., Phillips, I., et al. (2007). Rational design of memory in eukaryotic cells. Genes and Development, 21(18), 2271–2276. doi:10.1101/gad.1586107.CrossRef

Amidi, M., de Raad, M., de Graauw, H., van Ditmarsch, D., Hennink, W. E., Crommelin, D. J., et al. (2010). Optimization and quantification of protein synthesis inside liposomes. Journal of Liposome Research, 20(1), 73–83. doi:10.3109/08982100903402954.CrossRef

Anderson, J. C., Clarke, E. J., Arkin, A. P., & Voigt, C. A. (2006). Environmentally controlled invasion of cancer cells by engineered bacteria. Journal of Molecular Biology, 355(4), 619–627. doi:10.1016/j.jmb.2005.10.076.CrossRef

Anderson, J. C., Voigt, C. A., & Arkin, A. P. (2007). Environmental signal integration by a modular AND gate. Molecular Systems Biology, 3, 133. doi:10.1038/msb4100173.CrossRef

Andrianantoandro, E., Basu, S., Karig, D. K., & Weiss, R. (2006). Synthetic biology: New engineering rules for an emerging discipline. Molecular Systems Biology, 2, Article number: 2006.0028, doi:http://dx.doi.org/10.1038/msb4100073.

Anemaet, I. G., Bekker, M., & Hellingwerf, K. J. (2010). Algal photosynthesis as the primary driver for a sustainable development in energy, feed, and food production. Marine Biotechnology, 12(6), 619–629. doi:10.1007/s10126-010-9311-1.CrossRef

Arkin, A. (2008). Setting the standard in synthetic biology. Nature Biotechnology, 26(7), 771–774. doi:10.1038/nbt0708-771.CrossRef

Ball, P. (2005). Synthetic biology for nanotechnology. Nanotechnology, 16(1), R1–R8. doi:10.1088/0957-4484/16/1/R01.CrossRef

Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H., & Weiss, R. (2005). A synthetic multicellular system for programmed pattern formation. Nature, 434(7037), 1130–1134. doi:10.1038/nature03461.CrossRef

Basu, S., Mehreja, R., Thiberge, S., Chen, M. T., & Weiss, R. (2004). Spatiotemporal control of gene expression with pulse-generating networks. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6355–6360. doi:10.1073/pnas.0307571101.CrossRef

Bath, J., & Turberfield, A. J. (2007). DNA Nanomachines. Nature Nanotechnology, 2, 275–284. doi:10.1038/nnano.2007.104.CrossRef

Behrens, G. A., Hummel, A., Padhi, S. K., Schatzle, S., & Bornscheuer, U. T. (2011). Discovery and protein engineering of biocatalysts for organic synthesis. Advanced Synthesis and Catalysis, 353(13), 2191–2215. doi:10.1002/adsc.201100446.CrossRef

Benner, S. A. (2004). Understanding nucleic acids using synthetic chemistry. Accounts of Chemical Research, 37(10), 784–797. doi:10.1021/Ar040004z.CrossRef

Benner, S. A., & Sismour, A. M. (2005). Synthetic biology. Nature Reviews Genetics, 6(7), 533–543. doi:10.1038/nrg1637.CrossRef

Blankenship, R. E., Tiede, D. M., Barber, J., Brudvig, G. W., Fleming, G., Ghirardi, M., et al. (2011). Comparing photosynthetic and photovoltaic efficiencies and recognizing the potential for improvement. Science, 332(6031), 805–809. doi:10.1126/science.1200165.CrossRef

Brilli, M., Fani, R., & Lio, P. (2008). Current trends in the bioinformatic sequence analysis of metabolic pathways in prokaryotes. Briefings in Bioinformatics, 9(1), 34–45. doi:10.1093/bib/bbm051.CrossRef

Bromley, E. H., Channon, K., Moutevelis, E., & Woolfson, D. N. (2008). Peptide and protein building blocks for synthetic biology: From programming biomolecules to self-organized biomolecular systems. ACS Chemical Biology, 3(1), 38–50. doi:10.1021/cb700249v.CrossRef

Brunk, E., Neri, M., Tavernelli, I., Hatzimanikatis, V., & Rothlisberger, U. (2012). Integrating computational methods to retrofit enzymes to synthetic pathways. Biotechnology and Bioengineering, 109(2), 572–582. doi:10.1002/bit.23334.CrossRef

Bujara, M., & Panke, S. (2010). Engineering in complex systems. Current Opinion in Biotechnology, 21(5), 586–591, doi:http://dx.doi.org/10.1016/j.copbio.2010.07.007.

Cachat, E., & Davies, J. A. (2011). Application of synthetic biology to regenerative medicine. Journal of Bioengineering and Biomedical Sciences, 01(S2), doi:10.4172/2155-9538.s2-003.

Carothers, J. M., Goler, J. A., & Keasling, J. D. (2009). Chemical synthesis using synthetic biology. Current Opinion in Biotechnology, 20(4), 498–503. doi:10.1016/j.copbio.2009.08.001.CrossRef

Cartwright, J. H., & Checa, A. G. (2007). The dynamics of nacre self-assembly. Journal of the Royal Society, Interface, 4(14), 491–504. doi:10.1098/rsif.2006.0188.CrossRef

Chang, M. C., & Keasling, J. D. (2006). Production of isoprenoid pharmaceuticals by engineered microbes. Nature Chemical Biology, 2(12), 674–681. doi:10.1038/nchembio836.CrossRef

Chiarabelli, C., Stano, P., Anella, F., Carrara, P., & Luisi, P. L. (2012). Approaches to chemical synthetic biology. FEBS Letters, 586(15), 2138–2145. doi:10.1016/j.febslet.2012.01.014.CrossRef

Clomburg, J. M., & Gonzalez, R. (2010). Biofuel production in escherichia coli: The role of metabolic engineering and synthetic biology. Applied Microbiology and Biotechnology, 86(2), 419–434. doi:10.1007/s00253-010-2446-1.CrossRef

Collins, M. L., Irvine, B., Tyner, D., Fine, E., Zayati, C., Chang, C., et al. (1997). A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml. Nucleic Acids Research, 25(15), 2979–2984. doi:10.1093/nar/25.15.2979.CrossRef

de Lorenzo, V. (2009). Recombinant bacteria for environmental release: What went wrong and what we have learnt from it. Clinical Microbiology and Infection, 15(S1), 63–65. doi:10.1111/j.1469-0691.2008.02683.x.MathSciNetCrossRef

Dellomonaco, C., Fava, F., & Gonzalez, R. (2010). The path to next generation biofuels: Successes and challenges in the era of synthetic biology. Microbial Cell Factories, 9(3), 1–15. doi:10.1186/1475-2859-9-3.

Dethoff, E. A., Chugh, J., Mustoe, A. M., & Al-Hashimi, H. M. (2012). Functional complexity and regulation through RNA dynamics. Nature, 482, 322–330. doi:10.1038/nature10885.CrossRef

Elkins, J. G., Raman, B., & Keller, M. (2010). Engineered microbial systems for enhanced conversion of lignocellulosic biomass. Current Opinion in Biotechnology, 21(5), 657–662. doi:10.1016/j.copbio.2010.05.008.CrossRef

Ellis, T., Wang, X., & Collins, J. J. (2009). Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Nature Biotechnology, 27(5), 465–471. doi:10.1038/nbt.1536.CrossRef

Elowitz, M. B., & Leibler, S. (2000). A synthetic oscillatory network of transcriptional regulators. Nature, 403(6767), 335–338. doi:10.1038/35002125.CrossRef

Endy, D. (2005). Foundations for Engineering Biology. Nature, 438(7067), 449–453, doi:http://dx.doi.org/10.1038/nature04342.

Erickson, B., Nelson, J. E. & Winters, P. (2012). Perspective on opportunities in industrial biotechnology in renewable chemicals. Biotechnology Journal, 7(2), 176–185, doi:10.1002/biot.201100069.

Erickson, B., Singh, R., & Winters, P. (2011). Synthetic biology: Regulating industry uses of new biotechnologies. Science, 333(6047), 1254–1256. doi:10.1126/Science.1211066.CrossRef

Feher, T., Papp, B., Pal, C., & Posfai, G. (2007). Systematic genome reductions: Theoretical and experimental approaches. Chemical Reviews, 107(8), 3498–3513. doi:10.1021/cr0683111.CrossRef

Fellermann, H., Rasmussen, S., Ziock, H. J., & Sole, R. V. (2007). Life cycle of a minimal protocell: A dissipative particle dynamics study. Artificial Life, 13(4), 319–345. doi:10.1162/artl.2007.13.4.319.CrossRef

Forster, A. C., & Church, G. M. (2006). Towards synthesis of a minimal cell. Molecular Systems Biology, 2, Article number: 45, 45, doi:10.1038/msb4100090.

Fritz, G., Buchler, N. E., Hwa, T., & Gerland, U. (2007). Designing sequential transcription logic: A simple genetic circuit for conditional memory. Systems and Synthetic Biology, 1(2), 89–98. doi:10.1007/s11693-007-9006-8.CrossRef

Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000). Construction of a genetic toggle switch in Escherichia coli. Nature, 403(6767), 339–342. doi:10.1038/35002131.CrossRef

Garvey, M., Klose, H., Fischer, R., Lambertz, C., & Commandeur, U. (2013). Cellulases for biomass degradation: comparing recombinant cellulase expression platforms. Trends in Biotechnology, 31(10), 581–593. doi:10.1016/j.tibtech.2013.06.006.CrossRef

Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R. Y., Algire, M. A., et al. (2010). Creation of a bacterial cell controlled by a chemically synthesized genome. Science, 329(5987), 52–56. doi:10.1126/science.1190719.CrossRef

Giese, B., Koenigstein, S., Wigger, H., Schmidt, J. C., & Gleich, A. (2013). Rational engineering principles in synthetic biology: A framework for quantitative analysis and an initial assessment. Biological Theory, 8(4), 324–333. doi:10.1007/s13752-013-0130-2.CrossRef

Giese, B., & von Gleich, A. (2015). Hazards, risks, and low hazard development paths of synthetic biology. In B. Giese, C. Pade, H. Wigger, & A. von Gleich (Eds.), Synthetic biology : Character and impact (pp. 173–195). Berlin: Springer.

GR, RGO., & KNAW (Gesondheidsraad; Raad voor Gezondheidsonderzoek; Koninklijke Nederlandse Akademie van Wetenschappen). 2008. Synthetic Biology: Creating Opportunities. Report to the Minister of Education, Culture and Science Nr. 2008/19E. The Hague: Gezondheidsraad. Download: http://www.gezondheidsraad.nl/sites/default/files/200819E_0.pdf. Accessed 15 Oct 2013.

Greber, D., & Fussenegger, M. (2007). Mammalian synthetic biology: Engineering of sophisticated gene networks. Journal of Biotechnology, 130(4), 329–345. doi:10.1016/j.jbiotec.2007.05.014.CrossRef

Grunberg, R., & Serrano, L. (2010). Strategies for protein synthetic biology. Nucleic Acids Research, 38(8), 2663–2675. doi:10.1093/nar/gkq139.CrossRef

Guido, N. J., Wang, X., Adalsteinsson, D., McMillen, D., Hasty, J., Cantor, C. R., et al. (2006). A bottom-up approach to gene regulation. Nature, 439(7078), 856–860. doi:10.1038/nature04473.CrossRef

Heim, M., Keerl, D., & Scheibel, T. (2009). Spider silk: From soluble protein to extraordinary fiber. Angewandte Chemie International Edition, 48(20), 3584–3596. doi:10.1002/anie.200803341.CrossRef

Heinemann, M., & Panke, S. (2006). Synthetic biology: Putting engineering into biology. Bioinformatics, 22(22), 2790–2799. doi:10.1093/bioinformatics/btl469.CrossRef

Herdewijn, P., & Marliere, P. (2009). Toward safe genetically modified organisms through the chemical diversification of nucleic acids. Chemistry and Biodiversity, 6(6), 791–808. doi:10.1002/cbdv.200900083.CrossRef

Hoesl, M. G., & Budisa, N. (2011). In vivo incorporation of multiple noncanonical amino acids into proteins. Angewandte Chemie International Edition, 50(13), 2896–2902. doi:10.1002/anie.201005680.CrossRef

Isaacs, F. J., Dwyer, D. J., & Collins, J. J. (2006). RNA synthetic biology. Nature biotechnology, 24(5), 545–554. doi:10.1038/nbt1208.CrossRef

Jang, Y. S., Park, J. M., Choi, S., Choi, Y. J., Seung do, Y., Cho, J. H, et al. (2012). Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches. Biotechnology Advances, 30(5), 989–1000, doi:10.1016/j.biotechadv.2011.08.015.

Jewett, M. C. & Forster, A. C. (2010). Update on designing and building minimal cells. Current Opinion in Biotechnology, 21(5), 697–703, doi:10.1016/J.Copbio.2010.06.008.

Jung, S. K., Parisutham, V., Jeong, S. H. & Lee, S. K. (2012). Heterologous expression of plant cell wall degrading enzymes for effective production of cellulosic biofuels. Journal of Biomedicine and Biotechnology, 2012, Article number: 405842, 405842, doi:10.1155/2012/405842.

Khalil, A. S., & Collins, J. J. (2010). Synthetic biology: Applications come of age. Nature Reviews Genetics, 11(5), 367–379. doi:10.1038/nrg2775.CrossRef

King, N. P., Sheffler, W., Sawaya, M. R., Vollmar, B. S., Sumida, J. P., Andre, I., et al. (2012). Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science, 336(6085), 1171–1174. doi:10.1126/science.1219364.CrossRef

Kobayashi, H., Kaern, M., Araki, M., Chung, K., Gardner, T. S., Cantor, C. R., et al. (2004). Programmable cells: Interfacing natural and engineered gene networks. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8414–8419. doi:10.1073/pnas.0402940101.CrossRef

Kortemme, T., & Baker, D. (2004). Computational design of protein-protein interactions. Current Opinion in Chemical Biology, 8(1), 91–97. doi:10.1016/j.cbpa.2003.12.008.CrossRef

Kuruma, Y., Stano, P., Ueda, T., & Luisi, P. L. (2009). A synthetic biology approach to the construction of membrane proteins in semi-synthetic minimal cells. Biochimica et Biophysica Acta, 1788(2), 567–574. doi:10.1016/j.bbamem.2008.10.017.CrossRef

Kwok, R. (2010). Five hard truths for synthetic biology. Nature, 463(7279), 288–290. doi:http://dx.doi.org/10.1038/463288a.

Lamsen, E. N., & Atsumi, S. (2012). Recent progress in synthetic biology for microbial production of C3-C10 alcohols. Frontiers in microbiology, 3, 196.CrossRef

Lepthien, S., Merkel, L., & Budisa, N. (2010). In vivo double and triple labeling of proteins using synthetic amino acids. Angewandte Chemie International Edition, 49(32), 5446–5450. doi:10.1002/anie.201000439.CrossRef

Loakes, D., & Holliger, P. (2009). Darwinian chemistry: Towards the synthesis of a simple cell. Molecular BioSystems, 5(7), 686–694. doi:10.1039/B904024b.CrossRef

Lu, T. K., & Collins, J. J. (2009). Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proceedings of the National Academy of Sciences of the United States of America, 106(12), 4629–4634. doi:10.1073/Pnas.0800442106.CrossRef

Magnus, C. J., Lee, P. H., Atasoy, D., Su, H. H., Looger, L. L., & Sternson, S. M. (2011). Chemical and genetic engineering of selective ion channel-ligand interactions. Science, 333(6047), 1292–1296. doi:10.1126/science.1206606.CrossRef

Magnuson, A., Anderlund, M., Johansson, O., Lindblad, P., Lomoth, R., Polivka, T., et al. (2009). Biomimetic and microbial approaches to solar fuel generation. Accounts of Chemical Research, 42(12), 1899–1909. doi:10.1021/ar900127h.CrossRef

Marchisio, M. A., & Stelling, J. (2008). Computational design of synthetic gene circuits with composable parts. Bioinformatics, 24(17), 1903–1910. doi:10.1093/bioinformatics/btn330.CrossRef

Moya, A., Gil, R., Latorre, A., Pereto, J., Garcillan-Barcia, M. P., & de la Cruz, F. (2009). Toward minimal bacterial cells: Evolution vs. design. FEMS Microbiology Reviews, 33(1), 225–235. doi:10.1111/j.1574-6976.2008.00151.x.CrossRef

Na, D., Kim, T. Y., & Lee, S. Y. (2010). Construction and optimization of synthetic pathways in metabolic engineering. Current Opinion in Microbiology, 13(3), 363–370. doi:10.1016/j.mib.2010.02.004.CrossRef

Nangreave, J., Han, D., Liu, Y., & Yan, H. (2010). DNA origami: A history and current perspective. Current Opinion in Chemical Biology, 14(5), 608–615. doi:10.1016/j.cbpa.2010.06.182.CrossRef

NEST (New and Emerging Science and Technology [NEST] High-Level Expert Group). (2005). Synthetic Biology—Applying Engineering to Biology. Report Nr. EUR 21796. Brussels: Commission of the European Communities—Research Directorate General. Download: ftp://ftp.cordis.europa.eu/pub/nest/docs/syntheticbiology_b5_eur21796_en.pdf. Accessed: 30 Jul 2013.

Nielsen, J., & Keasling, J. D. (2011). Synergies between synthetic biology and metabolic engineering. Nature Biotechnology, 29(8), 693–695. doi:10.1038/nbt.1937.CrossRef

Nielsen, J., Larsson, C., van Maris, A., & Pronk, J. (2013). Metabolic engineering of yeast for production of fuels and chemicals. Current Opinion in Biotechnology, 24(3), 398–404. doi:10.1016/j.copbio.2013.03.023.CrossRef

Noireaux, V., Maeda, Y. T., & Libchaber, A. (2011). Development of an artificial cell, from self-organization to computation and self-reproduction. Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3473–3480. doi:10.1073/pnas.1017075108.CrossRef

Nourian, Z., Roelofsen, W., & Danelon, C. (2012). Triggered gene expression in fed-vesicle microreactors with a multifunctional membrane. Angewandte Chemie International Edition, 51(13), 3114–3118. doi:10.1002/Anie.201107123.CrossRef

Olson, D. G., McBride, J. E., Shaw, A. J., & Lynd, L. R. (2012). Recent progress in consolidated bioprocessing. Current Opinion in Biotechnology, 23(3), 396–405. doi:10.1016/j.copbio.2011.11.026.CrossRef

Peralta-Yahya, P. P., Zhang, F., del Cardayre, S. B., & Keasling, J. D. (2012). Microbial engineering for the production of advanced biofuels. Nature, 488(7411), 320–328. doi:10.1038/nature11478.CrossRef

Porcar, M., Danchin, A., de Lorenzo, V., Dos Santos, V. A., Krasnogor, N., Rasmussen, S., et al. (2011). The ten grand challenges of synthetic life. Systems and Synthetic Biology, 5(1–2), 1–9. doi:10.1007/s11693-011-9084-5.CrossRef

Prather, K. L. & Martin, C. H. (2008). De novo biosynthetic pathways: rational design of microbial chemical factories. Current Opinion in Biotechnology, 19(5), 468–474. doi:10.1016/J.Copbio.2008.07.009.

Purnick, P. E., & Weiss, R. (2009). The second wave of synthetic biology: From modules to systems. Nature Reviews Molecular Cell Biology, 10(6), 410–422. doi:10.1038/nrm2698.CrossRef

Richmond, D. L., Schmid, E. M., Martens, S., Stachowiak, J. C., Liska, N., & Fletcher, D. A. (2011). Forming giant vesicles with controlled membrane composition, asymmetry, and contents. Proceedings of the National Academy of Sciences of the United States of America, 108(23), 9431–9436. doi:10.1073/pnas.1016410108.CrossRef

Roodbeen, R., & van Hest, J. C. (2009). Synthetic cells and organelles: Compartmentalization strategies. BioEssays, 31(12), 1299–1308. doi:10.1002/bies.200900106.CrossRef

Rothemund, P. W. (2006). Folding DNA to create nanoscale shapes and patterns. Nature, 440(7082), 297–302. doi:10.1038/nature04586.CrossRef

Sacca, B., & Niemeyer, C. M. (2012). DNA origami: The art of folding DNA. Angewandte Chemie International Edition, 51(1), 58–66. doi:10.1002/anie.201105846.CrossRef

Saito, H., & Inoue, T. (2009). Synthetic biology with RNA motifs. The International Journal of Biochemistry and Cell Biology, 41(2), 398–404. doi:10.1016/j.biocel.2008.08.017.CrossRef

Schmidt, M. (2010). Xenobiology: A new form of life as the ultimate biosafety tool. BioEssays, 32(4), 322–331. doi:http://dx.doi.org/10.1002/bies.200900147.

Schwille, P., & Diez, S. (2009). Synthetic biology of minimal systems. Critical Reviews in Biochemistry and Molecular Biology, 44(4), 223–242. doi:10.1080/10409230903074549.CrossRef

Seeman, N. C. (1982). Nucleic acid junctions and lattices. Journal of Theoretical Biology, 99(2), 237–247. doi:10.1016/0022-5193(82)90002-9.CrossRef

Seeman, N. C. (2010). Nanomaterials based on DNA. Annual Review of Biochemistry, 79, 65–87. doi:10.1146/annurev-biochem-060308-102244.CrossRef

Shchukin, D. G., & Sukhorukov, G. B. (2004). Nanoparticle synthesis in engineered organic nanoscale reactors. Advanced Materials, 16(8), 671–682. doi:10.1002/adma.200306466.CrossRef

Sohka, T., Heins, R. A., Phelan, R. M., Greisler, J. M., Townsend, C. A., & Ostermeier, M. (2009). An externally tunable bacterial band-pass filter. Proceedings of the National Academy of Sciences of the United States of America, 106(25), 10135–10140. doi:10.1073/pnas.0901246106.CrossRef

Sole, R. V., Munteanu, A., Rodriguez-Caso, C., & Macia, J. (2007). Synthetic protocell biology: From reproduction to computation. Philosophical Transactions of the Royal Society of London, Series B—Biological Sciences, 362(1486), 1727–1739. doi:10.1098/rstb.2007.2065.

Suess, B., & Weigand, J. E. (2008). Engineered riboswitches: Overview problems and trends. RNA Biology, 5(1), 24–29. doi:10.4161/rna.5.1.5955.CrossRef

Szostak, J. W., Bartel, D. P., & Luisi, P. L. (2001). Synthesizing life. Nature, 409(6818), 387–390.CrossRef

Tian, J., Ma, K., & Saaem, I. (2009). Advancing high-throughput gene synthesis technology. Molecular BioSystems, 5(7), 714–722. doi:10.1039/b822268c.CrossRef

Uchida, M., Klem, M. T., Allen, M., Suci, P., Flenniken, M., Gillitzer, E., et al. (2007). Biological containers: Protein cages as multifunctional nanoplatforms. Advanced Materials, 19(8), 1025–1042. doi:10.1002/adma.200601168.CrossRef

Urban, P. L., Goodall, D. M., & Bruce, N. C. (2006). Enzymatic microreactors in chemical analysis and kinetic studies. Biotechnology Advances, 24(1), 42–57. doi:10.1016/j.biotechadv.2005.06.001.CrossRef

Van der Sloot, A. M., Kiel, C., Serrano, L., & Stricher, F. (2009). Protein design in biological networks: From manipulating the input to modifying the output. Protein Engineering, Design and Selection, 22(9), 537–542. doi:10.1093/protein/gzp032.CrossRef

Wang, L., Xie, J., & Schultz, P. G. (2006). Expanding the genetic code. Annual Review of Biophysics and Biomolecular Structure, 35, 225–249. doi:10.1146/annurev.biophys.35.101105.121507.CrossRef

Weber, W., Luzi, S., Karlsson, M., Sanchez-Bustamante, C. D., Frey, U., Hierlemann, A., et al. (2009). A synthetic mammalian electro-genetic transcription circuit. Nucleic Acids Research, 37(4), e33. doi:10.1093/nar/gkp014.CrossRef

Weber, W., Schoenmakers, R., Keller, B., Gitzinger, M., Grau, T., Daoud-El Baba, M., et al. (2008). A synthetic mammalian gene circuit reveals antituberculosis compounds. Proceedings of the National Academy of Sciences of the United States of America, 105(29), 9994–9998. doi:10.1073/pnas.0800663105.CrossRef

Weber, W., Stelling, J., Rimann, M., Keller, B., Daoud-El Baba, M., Weber, C. C., et al. (2007). A synthetic time-delay circuit in mammalian cells and mice. Proceedings of the National Academy of Sciences of the United States of America, 104(8), 2643–2648. doi:10.1073/pnas.0606398104.CrossRef

Widmaier, D. M., Tullman-Ercek, D., Mirsky, E. A., Hill, R., Govindarajan, S., Minshull, J, et al. (2009). Engineering the Salmonella type III secretion system to export spider silk monomers. Molecular Systems Biology, 5, Article number: 309, 309, doi:10.1038/msb.2009.62.

Wijffels, R. H., Kruse, O., & Hellingwerf, K. J. (2013). Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae. Current Opinion in Biotechnology, 24(3), 405–413. doi:10.1016/j.copbio.2013.04.004.CrossRef

Win, M. N., Liang, J. C., & Smolke, C. D. (2009). Frameworks for programming biological function through RNA parts and devices. Chemistry and Biology, 16(3), 298–310, doi:10.1016/J.Chembiol.2009.02.011.

Xie, Z., Wroblewska, L., Prochazka, L., Weiss, R., & Benenson, Y. (2011). Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science, 333(6047), 1307–1311. doi:10.1126/science.1205527.CrossRef

You, C., Zhang, X. Z., Sathitsuksanoh, N., Lynd, L. R., & Zhang, Y. H. (2012). Enhanced microbial utilization of recalcitrant cellulose by an ex vivo cellulosome-microbe complex. Applied and Environmental Microbiology, 78(5), 1437–1444. doi:10.1128/aem.07138-11.CrossRef

Titel: Characterizing Synthetic Biology Through Its Novel and Enhanced Functionalities
verfasst von: Christian Pade
Bernd Giese
Stefan Koenigstein
Henning Wigger
Arnim von Gleich
Verlag: Springer International Publishing
Buch: Synthetic Biology
Print ISBN: 978-3-319-02782-1

Electronic ISBN: 978-3-319-02783-8

Copyright-Jahr: 2015
DOI: https://doi.org/10.1007/978-3-319-02783-8_4

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