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2020 | OriginalPaper | Buchkapitel

Checking Phylogenetic Decisiveness in Theory and in Practice

verfasst von : Ghazaleh Parvini, Katherine Braught, David Fernández-Baca

Erschienen in: Bioinformatics Research and Applications

Verlag: Springer International Publishing

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Abstract

Suppose we have a set X consisting of n taxa and we are given information from k loci from which to construct a phylogeny for X. Each locus offers information for only a fraction of the taxa. The question is whether this data suffices to construct a reliable phylogeny. The decisiveness problem expresses this question combinatorially. Although a precise characterization of decisiveness is known, the complexity of the problem is open. Here we relate decisiveness to a hypergraph coloring problem. We use this idea to (1) obtain lower bounds on the amount of coverage needed to achieve decisiveness, (2) devise an exact algorithm for decisiveness, (3) develop problem reduction rules, and use them to obtain efficient algorithms for inputs with few loci, and (4) devise an integer linear programming formulation of the decisiveness problem, which allows us to analyze data sets that arise in practice.

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Vorheriges Kapitel MiRNA-Disease Associations Prediction Based on Negative Sample Selection and Multi-layer Perceptron

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Titel: Checking Phylogenetic Decisiveness in Theory and in Practice
verfasst von: Ghazaleh Parvini
Katherine Braught
David Fernández-Baca
Verlag: Springer International Publishing
Buch: Bioinformatics Research and Applications
Print ISBN: 978-3-030-57820-6

Electronic ISBN: 978-3-030-57821-3

Copyright-Jahr: 2020
DOI: https://doi.org/10.1007/978-3-030-57821-3_17

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